Search Results - "Michael, Helen"

Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas by Hernandez, Belen, Adissu, Hibret A, Wei, Bih-Rong, Michael, Helen T, Merlino, Glenn, Simpson, R Mark

“…Melanoma remains mostly an untreatable fatal disease despite advances in decoding cancer genomics and developing new therapeutic modalities. Progress in…”
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Improved Survival with Bevacizumab in Advanced Cervical Cancer by Tewari, Krishnansu S, Sill, Michael W, Long, Harry J, Penson, Richard T, Huang, Helen, Ramondetta, Lois M, Landrum, Lisa M, Oaknin, Ana, Reid, Thomas J, Leitao, Mario M, Michael, Helen E, Monk, Bradley J

“…In a large randomized clinical trial, the median survival among women with recurrent cervical cancer was 17 months when bevacizumab was added to their…”
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Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240) by Tewari, Krishnansu S, Sill, Michael W, Penson, Richard T, Huang, Helen, Ramondetta, Lois M, Landrum, Lisa M, Oaknin, Ana, Reid, Thomas J, Leitao, Mario M, Michael, Helen E, DiSaia, Philip J, Copeland, Larry J, Creasman, William T, Stehman, Frederick B, Brady, Mark F, Burger, Robert A, Thigpen, J Tate, Birrer, Michael J, Waggoner, Steven E, Moore, David H, Look, Katherine Y, Koh, Wui-Jin, Monk, Bradley J

“…On Aug 14, 2014, the US Food and Drug Administration approved the antiangiogenesis drug bevacizumab for women with advanced cervical cancer on the basis of…”
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A direct link between MITF, innate immunity, and hair graying by Harris, Melissa L, Fufa, Temesgen D, Palmer, Joseph W, Joshi, Sandeep S, Larson, Denise M, Incao, Arturo, Gildea, Derek E, Trivedi, Niraj S, Lee, Autumne N, Day, Chi-Ping, Michael, Helen T, Hornyak, Thomas J, Merlino, Glenn, Pavan, William J

“…Melanocyte stem cells (McSCs) and mouse models of hair graying serve as useful systems to uncover mechanisms involved in stem cell self-renewal and the…”
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Blood fibroblast growth factor 23 concentration in cats with and without chronic kidney disease: a scoping review by Summers, Stacie, Michael, Helen T, Szlosek, Donald, Mack, Rebekah

“…Objectives This study undertook a scoping review of research on blood fibroblast growth factor 23 (FGF-23) concentrations in healthy non-azotemic cats and cats…”
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Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevance by Day, Chi-Ping, Marchalik, Rachel, Merlino, Glenn, Michael, Helen

“…Melanocytes, a neural crest cell derivative, produce pigment to protect keratinocytes from ultraviolet radiation (UVR). Although melanocytic lesions such as…”
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A Topical Solution to the Sunless Tanning Problem by Michael, Helen T., Merlino, Glenn

“…Skin cancer is the most commonly diagnosed type of cancer and is strongly associated with UV exposure and skin pigmentation. Recent advances in pharmacologic…”
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Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis by Marie, Kerrie L., Sassano, Antonella, Yang, Howard H., Michalowski, Aleksandra M., Michael, Helen T., Guo, Theresa, Tsai, Yien Che, Weissman, Allan M., Lee, Maxwell P., Jenkins, Lisa M., Zaidi, M. Raza, Pérez-Guijarro, Eva, Day, Chi-Ping, Ylaya, Kris, Hewitt, Stephen M., Patel, Nimit L., Arnheiter, Heinz, Davis, Sean, Meltzer, Paul S., Merlino, Glenn, Mishra, Pravin J.

“…Cutaneous malignant melanoma is an aggressive cancer of melanocytes with a strong propensity to metastasize. We posit that melanoma cells acquire metastatic…”
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Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy by Pérez-Guijarro, Eva, Yang, Howard H., Araya, Romina E., El Meskini, Rajaa, Michael, Helen T., Vodnala, Suman Kumar, Marie, Kerrie L., Smith, Cari, Chin, Sung, Lam, Khiem C., Thorkelsson, Andres, Iacovelli, Anthony J., Kulaga, Alan, Fon, Anyen, Michalowski, Aleksandra M., Hugo, Willy, Lo, Roger S., Restifo, Nicholas P., Sharan, Shyam K., Van Dyke, Terry, Goldszmid, Romina S., Weaver Ohler, Zoe, Lee, Maxwell P., Day, Chi-Ping, Merlino, Glenn

“…Although immunotherapy has revolutionized cancer treatment, only a subset of patients demonstrate durable clinical benefit. Definitive predictive biomarkers…”
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Randomized phase III trial of gemcitabine plus docetaxel plus bevacizumab or placebo as first-line treatment for metastatic uterine leiomyosarcoma: an NRG Oncology/Gynecologic Oncology Group study by Hensley, Martee L, Miller, Austin, O'Malley, David M, Mannel, Robert S, Behbakht, Kian, Bakkum-Gamez, Jamie N, Michael, Helen

“…Fixed-dose rate gemcitabine plus docetaxel achieves objective response in 35% of patients with uterine leiomyosarcoma (uLMS). This study aimed to determine…”
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A phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva: A gynecologic oncology group study by Moore, David H, Ali, Shamshad, Koh, Wui-Jin, Michael, Helen, Barnes, Mack N, McCourt, Carolyn K, Homesley, Howard D, Walker, Joan L

“…Abstract Objectives To determine the efficacy and toxicity of radiation therapy and concurrent weekly cisplatin chemotherapy in achieving a complete clinical…”
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Advanced stage mucinous adenocarcinoma of the ovary is both rare and highly lethal by Zaino, Richard J., Brady, Mark F., Lele, Subodh M., Michael, Helen, Greer, Benjamin, Bookman, Michael A.

“…BACKGROUND: Primary mucinous adenocarcinomas of the ovary are uncommon, and their biological behavior is uncertain. Retrospective studies have suggested that…”
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Isolation and characterization of canine natural killer cells by Michael, Helen T., Ito, Daisuke, McCullar, Valarie, Zhang, Bin, Miller, Jeffrey S., Modiano, Jaime F.

“…NK cells are non-T, non-B lymphocytes that kill target cells without previous activation. The immunophenotype and function of these cells in humans and mice…”
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Final survival analysis of topotecan and paclitaxel for first-line treatment of advanced cervical cancer: An NRG oncology randomized study by Tewari, Krishnansu S., Sill, Michael W., Birrer, Michael J., Penson, Richard T., Huang, Helen, Moore, David H., Ramondetta, Lois M., Landrum, Lisa M., Oaknin, Ana, Reid, Thomas J., Leitao, Mario M., Michael, Helen E., Monk, Bradley J.

“…To determine whether a non‑platinum chemotherapy doublet improves overall survival (OS) among patients with recurrent/metastatic cervical carcinoma…”
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Bevacizumab for advanced cervical cancer: patient-reported outcomes of a randomised, phase 3 trial (NRG Oncology–Gynecologic Oncology Group protocol 240) by Penson, Richard T, Prof, Huang, Helen Q, MS, Wenzel, Lari B, Prof, Monk, Bradley J, Prof, Stockman, Sharon, BA, Long, Harry J, Prof, Ramondetta, Lois M, MD, Landrum, Lisa M, PhD, Oaknin, Ana, MD, Reid, Thomas J A, MD, Leitao, Mario M, MD, Method, Michael, MD, Michael, Helen, Prof, Tewari, Krishnansu S, Prof

“…Summary Background GOG 240 was a practice-changing randomised phase 3 trial that concluded that chemotherapy plus bevacizumab for advanced cervical cancer…”
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Prospective Validation of Pooled Prognostic Factors in Women with Advanced Cervical Cancer Treated with Chemotherapy with/without Bevacizumab: NRG Oncology/GOG Study by Tewari, Krishnansu S, Sill, Michael W, Monk, Bradley J, Penson, Richard T, Long, 3rd, Harry J, Poveda, Andrés, Landrum, Lisa M, Leitao, Mario M, Brown, Jubilee, Reid, Thomas J A, Michael, Helen E, Moore, David H

“…In the randomized phase III trial, Gynecologic Oncology Group (GOG) protocol 240, the incorporation of bevacizumab with chemotherapy significantly increased…”
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Circulating Tumor Cells In Advanced Cervical Cancer: NRG Oncology-Gynecologic Oncology Group Study 240 (NCT 00803062) by Tewari, Krishnansu S, Sill, Michael W, Monk, Bradley J, Penson, Richard T, Moore, David H, Lankes, Heather A, Ramondetta, Lois M, Landrum, Lisa M, Randall, Leslie M, Oaknin, Ana, Leitao, Mario M, Eisenhauer, Eric L, DiSilvestro, Paul, Van Le, Linda, Pearl, Michael L, Burke, James J, Salani, Ritu, Richardson, Debra L, Michael, Helen E, Kindelberger, David W, Birrer, Michael J

“…To isolate circulating tumor cells (CTC) from women with advanced cervical cancer and estimate the impact of CTCs and treatment on overall survival and…”
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Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma by Wei, Bih-Rong, Michael, Helen T., Halsey, Charles H.C., Peer, Cody J., Adhikari, Amit, Dwyer, Jennifer E., Hoover, Shelley B., El Meskini, Rajaa, Kozlov, Serguei, Weaver Ohler, Zoe, Figg, William. D., Merlino, Glenn, Simpson, R. Mark

“…Summary Human mucosal melanoma (MM), an uncommon, aggressive and diverse subtype, shares characteristics with spontaneous MM in dogs. Although BRAF and N‐RAS…”
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A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR by Xu, Mai, Mehl, Lindsey, Zhang, Tongwu, Thakur, Rohit, Sowards, Hayley, Myers, Timothy, Jessop, Lea, Chesi, Alessandra, Johnson, Matthew E., Wells, Andrew D., Michael, Helen T., Bunda, Patricia, Jones, Kristine, Higson, Herbert, Hennessey, Rebecca C., Jermusyk, Ashley, Kovacs, Michael A., Landi, Maria Teresa, Iles, Mark M., Goldstein, Alisa M., Choi, Jiyeon, Chanock, Stephen J., Grant, Struan F.A., Chari, Raj, Merlino, Glenn, Law, Matthew H., Brown, Kevin M.

“…Genome-wide association studies (GWASs) have identified a melanoma-associated locus on chromosome band 7p21.1 with rs117132860 as the lead SNP and a secondary…”
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Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice by Michael, Helen T, Graff-Cherry, Cari, Chin, Sung, Rauck, Corinne, Habtemichael, Amelework D, Bunda, Patricia, Smith, Tunde, Campos, Maria M, Bharti, Kapil, Arnheiter, Heinz, Merlino, Glenn, Day, Chi-Ping

“…Complete deficiency of microphthalmia transcription factor (MITF) in Mitfmi-vga9/mi-vga9 mice is associated with microphthalmia, retinal dysplasia, and…”
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