Search Results - "Michael, Anthony"
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Polyamines in Eukaryotes, Bacteria, and Archaea
Published in The Journal of biological chemistry (15-07-2016)“…Polyamines are primordial polycations found in most cells and perform different functions in different organisms. Although polyamines are mainly known for…”
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2
Polyamine function in archaea and bacteria
Published in The Journal of biological chemistry (30-11-2018)“…Most of the phylogenetic diversity of life is found in bacteria and archaea, and is reflected in the diverse metabolism and functions of bacterial and archaeal…”
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3
Biosynthesis of polyamines and polyamine-containing molecules
Published in Biochemical journal (01-08-2016)“…Polyamines are evolutionarily ancient polycations derived from amino acids and are pervasive in all domains of life. They are essential for cell growth and…”
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4
The buck stops with spermidine
Published in Nature chemical biology (01-07-2024)“…Sirtuins remove post-translationally added acyl groups from protein lysines. New work shows the surprising metabolic fate of acyl groups removed from…”
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5
Evolution of biosynthetic diversity
Published in Biochemical journal (15-07-2017)“…Since the emergence of the last common ancestor from which all extant life evolved, the metabolite repertoire of cells has increased and diversified. Not only…”
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6
Sensing spermidine through tongue-tied translation prevents too much of a good thing
Published in Molecular cell (07-10-2021)“…Vindu et al. (2021) identify the yeast high-affinity spermidine transporter, elucidate the mRNA uORF/eIF5a-based translational mechanism by which spermidine…”
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7
Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids
Published in The Plant journal : for cell and molecular biology (01-02-2014)“…The notion that plants use specialized metabolism to protect against environmental stresses needs to be experimentally proven by addressing the question of…”
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8
Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration
Published in Arthritis research & therapy (20-08-2014)“…The degenerate intervertebral disc (IVD) becomes innervated by sensory nerve fibres, and vascularised by blood vessels. This study aimed to identify…”
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9
The Transcendental Status of Beauty: Evaluating the Debate among Neo-Thomistic Philosophers
Published in Religions (Basel, Switzerland ) (01-10-2024)“…Over the past 150 years, Thomists have been divided over whether or not St. Thomas Aquinas himself held to the transcendentality of beauty. Francis J. Kovach…”
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10
A Libertarian Anarchist Analysis of Norman Geisler’s Philosophy of Government
Published in Religions (Basel, Switzerland ) (01-12-2023)“…There are numerous approaches and conclusions regarding church and state relations and how Christianity affects public policy. Yet the purpose of this study is…”
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11
Neofunctionalization of S-adenosylmethionine decarboxylase into pyruvoyl-dependent L-ornithine and L-arginine decarboxylases is widespread in bacteria and archaea
Published in The Journal of biological chemistry (01-08-2023)“…S-adenosylmethionine decarboxylase (AdoMetDC/SpeD) is a key polyamine biosynthetic enzyme required for conversion of putrescine to spermidine. Autocatalytic…”
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12
Functional polyamine metabolic enzymes and pathways encoded by the virosphere
Published in Proceedings of the National Academy of Sciences - PNAS (28-02-2023)“…Viruses produce more viruses by manipulating the metabolic and replication systems of their host cells. Many have acquired metabolic genes from ancestral hosts…”
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The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc
Published in Arthritis research & therapy (01-01-2013)“…The aims of these studies were to identify the cytokine and chemokine expression profile of nucleus pulposus (NP) cells and to determine the relationships…”
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14
The NIN transcription factor coordinates CEP and CLE signaling peptides that regulate nodulation antagonistically
Published in Nature communications (23-06-2020)“…Legumes tightly regulate nodule number to balance the cost of supporting symbiotic rhizobia with the benefits of nitrogen fixation. C-terminally Encoded…”
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15
Prediction of air quality in Sydney, Australia as a function of forest fire load and weather using Bayesian statistics
Published in PloS one (24-08-2022)“…Smoke from Hazard Reduction Burns (HRBs) and wildfires contains pollutants that are harmful to human health. This includes particulate matter less than 2.5 μm…”
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A Plant Pathogen Type III Effector Protein Subverts Translational Regulation to Boost Host Polyamine Levels
Published in Cell host & microbe (13-11-2019)“…Pathogenic bacteria inject effector proteins into host cells to manipulate cellular processes and facilitate the infection. Transcription-activator-like…”
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Polyamine Oxidase5 Regulates Arabidopsis Growth through Thermospermine Oxidase Activity
Published in Plant physiology (Bethesda) (01-08-2014)“…The major plant polyamines (PAs) are the tetraamines spermine (Spm) and thermospermine (T-Spm), the triamine spermidine, and the diamine putrescine. PA…”
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Discovery of ancestral L-ornithine and L-lysine decarboxylases reveals parallel, pseudoconvergent evolution of polyamine biosynthesis
Published in The Journal of biological chemistry (01-10-2021)“…Polyamines are fundamental molecules of life, and their deep evolutionary history is reflected in extensive biosynthetic diversification. The polyamines…”
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Polycomb repressive complex 2 regulates MiR-200b in retinal endothelial cells: potential relevance in diabetic retinopathy
Published in PloS one (17-04-2015)“…Glucose-induced augmented vascular endothelial growth factor (VEGF) production is a key event in diabetic retinopathy. We have previously demonstrated that…”
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Researching Rural Development: Selected Reflections
Published in World (Basel) (01-12-2022)“…Reflections on research can take many forms. They inevitably contain positive memories of research that advanced our knowledge on issues of the day. They can…”
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