Impairments in expression of devaluation in a Pavlovian goal-tracking task, but not a free operant devaluation task, after fentanyl exposure in female rats

In laboratory animals, there are numerous demonstrations that past exposure to drugs of abuse can lead to devaluation impairments weeks after the final drug exposure, with the majority of these demonstrations examining effects of exposure to psychostimulants. There has been minimal investigation int...

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Bibliographic Details
Published in:	Behavioural brain research Vol. 458; p. 114761
Main Authors:	Pickens, Charles L, Hougham, Alyssa, Kim, Jihyeon, Wang, Chuhan, Leder, Jendaya, Line, Chelsea, McDaniel, Kathleen, Micek, Lydia, Miller, Jadyn, Powell, Kendall, Waren, Olivia, Brenneman, Ellie, Erdley, Brooke
Format:	Journal Article
Language:	English
Published:	Netherlands 26-02-2024
Subjects:	Animals Central Nervous System Stimulants - pharmacology Conditioning, Classical - physiology Conditioning, Operant Female Goals Rats Rats, Long-Evans Decision-making Fentanyl Opiates Devaluation Addiction
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Summary:	In laboratory animals, there are numerous demonstrations that past exposure to drugs of abuse can lead to devaluation impairments weeks after the final drug exposure, with the majority of these demonstrations examining effects of exposure to psychostimulants. There has been minimal investigation into whether prior exposure to opiates can lead to devaluation impairments. Here, we first trained female rats that two separate cuelights predicted two different foods and measured Pavlovian goal-tracking responses (Experiment 1) or trained female rats to press two levers to earn two different foods and measured this operant response (Experiment 2). In both experiments, we subsequently gave the rats injections of fentanyl twice daily for 6 days, and then tested rats for conditioned responses after satiation on one of the foods 48-h after the final injection. We found that rats were impaired in the expression of devaluation in the Pavlovian task after fentanyl exposure, but were unimpaired in the expression of devaluation in the operant task. The pattern of results is most consistent with an impairment in lateral orbitofrontal cortex function, but additional research is needed to determine the neurobiological cause of this pattern of results.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0166-4328 1872-7549
DOI:	10.1016/j.bbr.2023.114761