Search Results - "Miar, Ana"

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors by Reisländer, Timo, Lombardi, Emilia Puig, Groelly, Florian J., Miar, Ana, Porru, Manuela, Di Vito, Serena, Wright, Benjamin, Lockstone, Helen, Biroccio, Annamaria, Harris, Adrian, Londoño-Vallejo, Arturo, Tarsounas, Madalena

“…Heterozygous germline mutations in BRCA2 predispose to breast and ovarian cancer. Contrary to non-cancerous cells, where BRCA2 deletion causes cell cycle…”
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Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer by Hevia, David, González-Menéndez, Pedro, Quiros-González, Isabel, Miar, Ana, Rodríguez-García, Aida, Tan, Dun-Xian, Reiter, Russel J., Mayo, Juan C., Sainz, Rosa M.

“…Melatonin is present in a multitude of taxa and it has a broad range of biological functions, from synchronizing circadian rhythms to detoxifying free…”
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Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study by Jayathilake, Pahala Gedara, Victori, Pedro, Pavillet, Clara E, Lee, Chang Heon, Voukantsis, Dimitrios, Miar, Ana, Arora, Anjali, Harris, Adrian L, Morten, Karl J, Buffa, Francesca M

“…Deregulated metabolism is one of the hallmarks of cancer. It is well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen is…”
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Differential effects of HIF2α antagonist and HIF2α silencing in renal cancer and sensitivity to repurposed drugs by Arnaiz, Esther, Miar, Ana, Bridges, Esther, Prasad, Naveen, Hatch, Stephanie B, Ebner, Daniel, Lawrie, Charles H, Harris, Adrian L

“…In clear cell renal cell carcinoma, 80% of cases have biallelic inactivation of the VHL gene, leading to constitutive activation of both HIF1α and HIF2α. As…”
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Hypoxia Regulates Endogenous Double-Stranded RNA Production via Reduced Mitochondrial DNA Transcription by Arnaiz, Esther, Miar, Ana, Dias Junior, Antonio Gregorio, Prasad, Naveen, Schulze, Ulrike, Waithe, Dominic, Nathan, James A, Rehwinkel, Jan, Harris, Adrian L

“…Hypoxia is a common phenomenon in solid tumours strongly linked to the hallmarks of cancer. Hypoxia promotes local immunosuppression and downregulates type I…”
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A machine learning and directed network optimization approach to uncover TP53 regulatory patterns by Triantafyllidis, Charalampos P., Barberis, Alessandro, Hartley, Fiona, Cuervo, Ana Miar, Gjerga, Enio, Charlton, Philip, van Bijsterveldt, Linda, Rodriguez, Julio Saez, Buffa, Francesca M.

“…TP53, the Guardian of the Genome, is the most frequently mutated gene in human cancers and the functional characterization of its regulation is fundamental. To…”
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Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response by Yalaz, Ceren, Bridges, Esther, Alham, Nasullah K, Zois, Christos E, Chen, Jianzhou, Bensaad, Karim, Miar, Ana, Pires, Elisabete, Muschel, Ruth J, McCullagh, James S O, Harris, Adrian L

“…PDE6H encodes PDE6γ', the inhibitory subunit of the cGMP-specific phosphodiesterase 6 in cone photoreceptors. Inhibition of PDE6, which has been widely studied…”
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Lack of association between protocadherin 11-X/Y ( PCDH11X and PCDH11Y ) polymorphisms and late onset Alzheimer's disease by Miar, Ana, Álvarez, Victoria, Corao, Ana I, Alonso, Belén, Díaz, Marta, Menéndez, Manuel, Martínez, Carmen, Calatayud, Maite, Morís, Germán, Coto, Eliecer

“…Abstract A recent genome-wide association study (GWA) reported a significant association between single nucleotide polymorphisms (SNPs) at the PCDH11X gene and…”
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WED-548 - Development of a 2D nonalcohol-related steatohepatitis (NASH) model by Gonzalez, Esther Arnaiz, Choudhury, Tahmid, Miar, Ana, Moore, Kenny, Lin, Yuan-Yu, Lu, Tess, Wills, Quin

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Development of a 2D nonalcohol-related steatohepatitis (NASH) model by Gonzalez, Esther Arnaiz, Choudhury, Tahmid, Miar, Ana, Moore, Kenny, Lin, Yuan-Yu, Lu, Tess, Wills, Quin

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Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types by Miar, Ana, Arnaiz, Esther, Bridges, Esther, Beedie, Shaunna, Cribbs, Adam P, Downes, Damien J, Beagrie, Robert A, Rehwinkel, Jan, Harris, Adrian L

“…Hypoxia is a common phenomenon in solid tumors and is strongly linked to hallmarks of cancer. Recent evidence has shown that hypoxia promotes local immune…”
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Abstract 521: Downregulation of type I IFN response in hypoxia as a possible mechanism of immune escape by Miar, Ana, Rehwinkel, Jan, Zois, Christos, Harris, Adrian L.

“…Introduction: Hypoxia is a common phenomenon in solid tumors and is considered a hallmark of cancer. Increasing evidence shows that tumor hypoxia promotes…”
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Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer by Miar, Ana, Hevia, David, Muñoz-Cimadevilla, Henar, Astudillo, Aurora, Velasco, Julio, Sainz, Rosa M., Mayo, Juan C.

“…The role of manganese-dependent superoxide dismutase (SOD2/MnSOD) during tumor progression has been studied for several decades with controversial results…”
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Differential effects of HIF2[alpha] antagonist and HIF2[alpha] silencing in renal cancer and sensitivity to repurposed drugs by Arnaiz, Esther, Miar, Ana, Bridges, Esther, Prasad, Naveen, Hatch, Stephanie B, Ebner, Daniel, Lawrie, Charles H, Harris, Adrian L

“…Background In clear cell renal cell carcinoma, 80% of cases have biallelic inactivation of the VHL gene, leading to constitutive activation of both HIF1[alpha]…”
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Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types by Miar, Ana, Arnaiz, Esther, Bridges, Esther, Beedie, Shaunna, Cribbs, Adam P., Downes, Damien J., Beagrie, Robert A., Rehwinkel, Jan, Harris, Adrian L.

“…Hypoxia is a common phenomenon in solid tumors and is strongly linked to hallmarks of cancer. Recent evidence has shown that hypoxia promotes local immune…”
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Fluciclovine (^sup 18^F) is a marker for high-affinity glutamine transporter ASCT2-mediated amino acid transport in breast cancer by Teoh, Eugene, Morotti, Matteo, Bridges, Esther, Jones, Dylan, Miar, Ana, Wigfield, Simon, Zois, Christos, Gleeson, Fergus, Harris, Adrian

“…Objectives: To elucidate the uptake mechanisms of the amino acid PET tracer fluciclovine (anti-1-amino-3-fluorocyclobutane-1-carboxylic acid / FACBC) in breast…”
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FGF20 rs12720208 SNP and microRNA-433 variation: No association with Parkinson's disease in Spanish patients by de Mena, Lorena, Cardo, Lucía F., Coto, Eliecer, Miar, Ana, Díaz, Marta, Corao, Ana I., Alonso, Belén, Ribacoba, René, Salvador, Carlos, Menéndez, Manuel, Morís, Germán, Alvarez, Victoria

“…DNA variation at the FGF20 gene has been associated with Parkinson's disease (PD). In particular, SNP rs12720208 in the 3′ untranslated region (3′ UTR) was…”
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Development and validation of a single HPLC method for determination of α-tocopherol in cell culture and in human or mouse biological samples by Cimadevilla, Henar M., Hevia, David, Miar, Ana, Mayo, Juan C., Lombo, Felipe, Sainz, Rosa M.

“…A straightforward and common analytical method for α‐tocopherol (αT) determination in various biological samples, including plasma, red blood cells (RBC),…”
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Amyloid Precursor Protein Gene (APP) Variation in Late-Onset Alzheimer’s Disease by Miar, Ana, Álvarez, Victoria, Corao, Ana I., Díaz, Marta, Alonso, Belén, Martínez, Carmen, Calatayud, María T., Menéndez, Manuel, Morís, Germán, Coto, Eliecer

“…Mutations in the beta-amyloid precursor protein gene ( APP ) have been found in familial early-onset Alzheímer’s disease (AD). DNA variants at several genes…”
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The spectrum of SCN5A gene mutations in Spanish Brugada syndrome patients by García-Castro, Mónica, García, Cristina, Reguero, Julián R, Miar, Ana, Rubín, José M, Alvarez, Victoria, Morís, César, Coto, Eliecer

“…Brugada syndrome is characterized by right bundle branch block and ST-segment elevation in the right precordial ECG leads. Familial transmission is frequent…”
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