Search Results - "Miao, Ze‐Hong"

An Update on Poly(ADP-ribose)polymerase‑1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy by Wang, Ying-Qing, Wang, Ping-Yuan, Wang, Yu-Ting, Yang, Guang-Fu, Zhang, Ao, Miao, Ze-Hong

“…Poly­(ADP-ribose)­polymerase-1 (PARP-1) is a critical DNA repair enzyme in the base excision repair pathway. Inhibitors of this enzyme comprise a new type of…”
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Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms by Zhou, Zhao-Li, Yang, Ya-Xi, Ding, Jian, Li, Yuan-Chao, Miao, Ze-Hong

“…Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid…”
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Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy by Zhang, Qian, Wu, Qian, Huan, Xia-Juan, Song, Shan-Shan, Bao, Xu-Bin, Miao, Ze-Hong, Wang, Ying-Qing

“…[Display omitted] Agents that inhibit bromodomain and extra-terminal domain (BET) proteins have been actively tested in the clinic as potential anticancer…”
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Increased PARP1‐DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1‐DNA trapping is correlated with PARP1 inhibitor's cytotoxicity by Chen, Hua‐Dong, Chen, Chuan‐Huizi, Wang, Yu‐Ting, Guo, Ne, Tian, Yu‐Nan, Huan, Xia‐Juan, Song, Shan‐Shan, He, Jin‐Xue, Miao, Ze‐Hong

“…PARP1 inhibitors (PARPis) are used clinically during cancer therapy and are thought to exert their cytotoxicity through PARP1 polymerase inhibition and…”
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Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance by Wang, Li‐Min, Wang, Pingyuan, Chen, Xiao‐Min, Yang, Hui, Song, Shan‐Shan, Song, Zilan, Jia, Li, Chen, Hua‐Dong, Bao, Xu‐Bin, Guo, Ne, Huan, Xia‐Juan, Xi, Yong, Shen, Yan‐Yan, Yang, Xin‐Ying, Su, Yi, Sun, Yi‐Ming, Gao, Ying‐Lei, Chen, Yi, Ding, Jian, Lang, Jing‐Yu, Miao, Ze‐Hong, Zhang, Ao, He, Jin‐Xue

“…Poly‐ADP‐ribose polymerase (PARP) inhibitors (PARPi) have shown great promise for treating BRCA‐deficient tumors. However, over 40% of BRCA‐deficient patients…”
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Acquired resistance of phosphatase and tensin homolog‐deficient cells to poly(ADP‐ribose) polymerase inhibitor and Ara‐C mediated by 53BP1 loss and SAMHD1 overexpression by Wang, Yu‐Ting, Yuan, Bo, Chen, Hua‐Dong, Xu, Lin, Tian, Yu‐Nan, Zhang, Ao, He, Jin‐Xue, Miao, Ze‐Hong

“…With increasing uses of poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPi) for cancer therapy, understanding their resistance is becoming urgent. However,…”
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Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells by Li, Jing-qiu, Wu, Xian, Gan, Lu, Yang, Xiang-liang, Miao, Ze-hong

“…Hepatocellular carcinoma （HCC） is one of the most refractory cancers. The mechanisms by which hypoxia further aggravates therapeutic responses of advanced HCC…”
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Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer by Zhang, Ning, Tian, Yu-Nan, Zhou, Li-Na, Li, Meng-Zhu, Chen, Hua-Dong, Song, Shan-Shan, Huan, Xia-Juan, Bao, Xu-Bin, Zhang, Ao, Miao, Ze-Hong, He, Jin-Xue

“…Monotherapy with poly ADP-ribose polymerase (PARP) inhibitors results in a limited objective response rate (≤60% in most cases) in patients with homologous…”
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Marine-derived angiogenesis inhibitors for cancer therapy by Wang, Ying-Qing, Miao, Ze-Hong

“…Angiogenesis inhibitors have been successfully used for cancer therapy in the clinic. Many marine-derived natural products and their analogues have been…”
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Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II by GIUSTINO MANZO, Stefano, ZHOU, Zhao-Li, WANG, Ying-Qing, MARINELLO, Jessica, HE, Jin-Xue, LI, Yuan-Chao, JIAN DING, CAPRANICO, Giovanni, MIAO, Ze-Hong

“…Triptolide is a bioactive ingredient in traditional Chinese medicine that exhibits diverse biologic properties, including anticancer properties. Among its many…”
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SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy by Zhou, Li-Na, Xiong, Chaodong, Cheng, Yong-Jun, Song, Shan-Shan, Bao, Xu-Bin, Huan, Xia-Juan, Wang, Tong-Yan, Zhang, Ao, Miao, Ze-Hong, He, Jin-Xue

“…Inhibition of the NEDD8-activating enzyme (NAE), the key E1 enzyme in the neddylation cascade, has been considered an attractive anticancer strategy with the…”
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Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter by Tian, Yu-Nan, Chen, Hua-Dong, Tian, Chang-Qing, Wang, Ying-Qing, Miao, Ze-Hong

“…Poly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a…”
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Poly(ADP-ribose)polymerase (PARP) Inhibition and Anticancer Activity of Simmiparib, a New Inhibitor Undergoing Clinical Trials by Yuan, Bo, Ye, Na, Song, Shan-Shan, Wang, Yu-Ting, Song, Zilan, Chen, Hua-Dong, Chen, Chuan-Huizi, Huan, Xia-Juan, Wang, Ying-Qing, Su, Yi, Shen, Yan-Yan, Sun, Yi-Ming, Yang, Xin-Ying, Chen, Yi, Guo, Shi-Yan, Gan, Yong, Gao, Zhi-Wei, Chen, Xiao-Yan, Ding, Jian, He, Jin-Xue, Dr, Zhang, Ao, Dr, Miao, Ze-Hong, Dr

“…Abstract Poly(ADP-ribose)polymerase (PARP)1/2 inhibitors have been proved to be clinically effective anticancer drugs. Here we report a new PARP1/2 inhibitor,…”
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Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti‐tumoral Activities by Yin, Fang‐Zhou, Huan, Xia‐Juan, Mudianta, I. Wayan, Miao, Ze‐Hong, Wang, Hong, Guo, Yue‐Wei, Li, Xu‐Wen

“…Main observation and conclusion Four new cembranoids, 6‐oxo‐cembrene‐A (1), lobocrassins G—H (2—3), and 14‐epi‐lobophytolide B (4), along with eight known…”
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Chemical constituents from the South China sea soft coral Sinularia humilis by Li, Jie, Huan, Xia-Juan, Wu, Meng-Jun, Chen, Zi-Hui, Chen, Bao, Miao, Ze-Hong, Guo, Yue-Wei, Li, Xu-Wen

“…A new diterpenoid with an unusual capnosane skeleton, sinuhumilol A (1), alone with twelve known diverse compounds (2-13), were isolated from the South China…”
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New microtubulin inhibitor MT189 suppresses angiogenesis via the JNK-VEGF/VEGFR2 signaling axis by Xu, Lin, Wang, Wei, Meng, Tao, Ma, Lan-Ping, Tong, Lin-Jiang, Shen, Jing-Kang, Wang, Ying-Qing, Miao, Ze-Hong

“…The microtubulin inhibitor MT189 possesses anticancer activity and has been shown to overcome multidrug resistance. Here, we report that MT189 also inhibits…”
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Inhibition of the BET family reduces its new target gene IDO1 expression and the production of l-kynurenine by Tian, Chang-Qing, Chen, Lin, Chen, Hua-Dong, Huan, Xia-Juan, Hu, Jian-Ping, Shen, Jing-Kang, Xiong, Bing, Wang, Ying-Qing, Miao, Ze-Hong

“…The bromodomain and extra terminal domain (BET) family members, including BRD2, BRD3, and BRD4, act as epigenetic readers to regulate gene expression…”
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Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers by Li, Meng-Zhu, Meng, Tao, Song, Shan-Shan, Bao, Xu-Bin, Ma, Lan-Ping, Zhang, Ning, Yu, Ting, Zhang, Yong-Liang, Xiong, Bing, Shen, Jing-Kang, Miao, Ze-Hong, He, Jin-Xue

“…Summary G-quadruplexes (G4s) are DNA or RNA structures formed by guanine-rich repeating sequences. Recently, G4s have become a highly attractive therapeutic…”
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Uncommon Bis‐quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis by Chen, Bao, Huan, Xia‐Juan, Miao, Ze‐Hong, Voogd, Nicole J., Gu, Yu‐Cheng, Wang, Chang‐Yun, Guo, Yue‐Wei, Li, Xu‐Wen

“…Main observation and conclusion Two new bis‐quinolizidine alkaloids, neopetrosiasins A (1) and B (2), possessing cis‐ and trans‐quinolizidine nuclei, one known…”
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Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa , Phyllidia coelestis , and Their Sponge-Prey Acanthella cavernosa by Wu, Qihao, Chen, Wen-Ting, Li, Song-Wei, Ye, Jian-Yu, Huan, Xia-Juan, Gavagnin, Margherita, Yao, Li-Gong, Wang, Hong, Miao, Ze-Hong, Li, Xu-Wen, Guo, Yue-Wei

“…A detailed chemical investigation of two South China Sea nudibranchs and , as well as their possible sponge-prey , led to the isolation of one new nitrogenous…”
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