Search Results - "Miao, Yimin"
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Bioorthogonal catalytic patch
Published in Nature nanotechnology (01-08-2021)“…Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial chemistry complementary to enzymatic reactions, enabling the…”
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Dynamic Short Hydrogen Bonds in Histidine Tetrad of Full-Length M2 Proton Channel Reveal Tetrameric Structural Heterogeneity and Functional Mechanism
Published in Structure (London) (01-12-2015)“…The tetrameric M2 protein from influenza A conducts protons into the virus upon acid activation of its His37 tetrad and is a proven drug target. Here, in…”
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M2 Proton Channel Structural Validation from Full-Length Protein Samples in Synthetic Bilayers and E. coli Membranes
Published in Angewandte Chemie International Edition (13-08-2012)“…Validation: Membrane protein structures are sensitive to the environment used for structural characterization. NMR spectra of the full‐length M2 proton channel…”
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Probing Hydronium Ion Histidine NH Exchange Rate Constants in the M2 Channel via Indirect Observation of Dipolar-Dephased 15N Signals in Magic-Angle-Spinning NMR
Published in Journal of the American Chemical Society (14-12-2016)“…Water–protein chemical exchange in membrane-bound proteins is an important parameter for understanding how proteins interact with their aqueous environment,…”
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Observation of the Imidazole-Imidazolium Hydrogen Bonds Responsible for Selective Proton Conductance in the Influenza A M2 Channel
Published in Journal of the American Chemical Society (05-02-2020)“…The integral membrane M2 protein is a 97-residue membrane protein that assembles as a tetramer to conduct protons at a slow rate (102–103/s) when activated by…”
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Evolutionary and genotypic analyses of global porcine epidemic diarrhea virus strains
Published in Transboundary and emerging diseases (01-01-2019)“…Porcine epidemic diarrhea virus (PEDV), which re‐emerged in China in October 2010, has spread rapidly worldwide. Detailed analyses of the complete genomes of…”
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M2 Proton Channel Structural Validation from Full-Length Protein Samples in Synthetic Bilayers and E. coli Membranes
Published in Angewandte Chemie (13-08-2012)“…Glaubwürdig: Die Struktur von Membranproteinen hängt von der in der Strukturcharakterisierung verwendeten Umgebung ab. NMR‐Spektren des tetrameren…”
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Solid state NMR and protein–protein interactions in membranes
Published in Current opinion in structural biology (01-12-2013)“…•Multiple examples of homo- or hetero-oligomeric protein–protein complexes discussed.•Membrane environments influence membrane protein–protein…”
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Membrane Topology of an Ion Channel Detected by Solid-State Nuclear Magnetic Resonance and Paramagnetic Effects
Published in The journal of physical chemistry letters (19-11-2020)“…Ion channels are often targeted by toxins or other ligands to modify their channel activities and alter ion conductance. Interactions between toxins and ion…”
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The mortise and tenon structure enabling lamellar carbon composites of ultra-high bending strength
Published in Journal of materials science & technology (10-01-2023)“…•A novel approach is reported to produce carbon/carbon fiber composites of super bending strengths from nano diamonds and carbon fibers via a phase…”
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Beyond Structural Biology to Functional Biology: Solid-State NMR Experiments and Strategies for Understanding the M2 Proton Channel Conductance
Published in The journal of physical chemistry. B (11-05-2017)“…In terms of structural biology, solid-state NMR experiments and strategies have been well established for resonance assignments, leading to the determination…”
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Differentiation of histidine tautomeric states using (15)N selectively filtered (13)C solid-state NMR spectroscopy
Published in Journal of magnetic resonance (1997) (01-08-2014)“…The histidine imidazole ring in proteins usually contains a mixture of three possible tautomeric states (two neutral - τ and π states and a charged state) at…”
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Identifying inter-residue resonances in crowded 2D (13)C- (13)C chemical shift correlation spectra of membrane proteins by solid-state MAS NMR difference spectroscopy
Published in Journal of biomolecular NMR (01-07-2013)“…The feasibility of using difference spectroscopy, i.e. subtraction of two correlation spectra at different mixing times, for substantially enhanced resolution…”
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Differentiation of histidine tautomeric states using super(15)N selectively filtered super(13)C solid-state NMR spectroscopy
Published in Journal of magnetic resonance (1997) (01-08-2014)“…The histidine imidazole ring in proteins usually contains a mixture of three possible tautomeric states (two neutral - tau and pi states and a charged state)…”
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Differentiation of histidine tautomeric states using 15N selectively filtered 13C solid-state NMR spectroscopy
Published in Journal of magnetic resonance (1997) (01-08-2014)“…[Display omitted] •1D 15N filtered 13C ssNMR spectroscopy is proposed to differentiate histidine tautomers.•15N selective pulses are used to choose…”
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Probing Hydronium Ion Histidine NH Exchange Rate Constants in the M2 Channel via Indirect Observation of Dipolar-Dephased 15 N Signals in Magic-Angle-Spinning NMR
Published in Journal of the American Chemical Society (14-12-2016)“…Water-protein chemical exchange in membrane-bound proteins is an important parameter for understanding how proteins interact with their aqueous environment,…”
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Identifying inter-residue resonances in crowded 2D ^sup 13^C-^sup 13^C chemical shift correlation spectra of membrane proteins by solid-state MAS NMR difference spectroscopy
Published in Journal of biomolecular NMR (01-07-2013)“…The feasibility of using difference spectroscopy, i.e. subtraction of two correlation spectra at different mixing times, for substantially enhanced resolution…”
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Identifying inter-residue resonances in crowded 2D 13C–13C chemical shift correlation spectra of membrane proteins by solid-state MAS NMR difference spectroscopy
Published in Journal of biomolecular NMR (01-07-2013)“…The feasibility of using difference spectroscopy, i.e. subtraction of two correlation spectra at different mixing times, for substantially enhanced resolution…”
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Unique Insights into the Structural and Functional Biology of Membrane Proteins from Solid State NMR Spectroscopy
Published in Biophysical journal (02-02-2018)Get full text
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