Search Results - "Miao, Clara"

Effect of Structural Modification of Enol−Carboxamide-Type Nonsteroidal Antiinflammatory Drugs on COX-2/COX-1 Selectivity by Lazer, Edward S, Miao, Clara K, Cywin, Charles L, Sorcek, Ronald, Wong, Hin-Chor, Meng, Zhaoxing, Potocki, Ian, Hoermann, MaryAnn, Snow, Roger J, Tschantz, Matt A, Kelly, Terence A, McNeil, Daniel W, Coutts, Simon J, Churchill, Laurie, Graham, Anne G, David, Eva, Grob, Peter M, Engel, Wolfhard, Meier, Hans, Trummlitz, Günter

“…Meloxicam (5), an NSAID in the enol−carboxamide class, was developed on the basis of its antiinflammatory activity and relative safety in animal models. In…”
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Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones by Skiles, Jerry W, Fuchs, Victor, Miao, Clara, Sorcek, Ronald, Grozinger, Karl G, Mauldin, Scott C, Vitous, Jana, Mui, Philip W, Jacober, Stephen

“…A series of tripeptides possessing trifluoromethyl or aryl ketone residues at P1 were prepared and evaluated both in vitro and in vivo as potential inhibitors…”
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Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action by Lazer, Edward S, Miao, Clara K, Wong, Hin-Chor, Sorcek, Ronald, Spero, Denice M, Gilman, Alex, Pal, Kollol, Behnke, Mark, Graham, Anne G

“…A series of benzoxazolamine and benzothiazolamine analogs that inhibit leukotriene (LT) biosynthesis are described. The initial lead, (S)-N-(benzothiazol-2-…”
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Second-Generation Lymphocyte Function-Associated Antigen-1 Inhibitors:  1H-Imidazo[1,2-α]imidazol-2-one Derivatives by Wu, Jiang-Ping, Emeigh, Jonathan, Gao, Donghong A, Goldberg, Daniel R, Kuzmich, Daniel, Miao, Clara, Potocki, Ian, Qian, Kevin C, Sorcek, Ronald J, Jeanfavre, Deborah D, Kishimoto, Kei, Mainolfi, Elizabeth A, Nabozny, Gerald, Peng, Charline, Reilly, Patricia, Rothlein, Robert, Sellati, Rosemarie H, Woska, Joseph R, Chen, Shirlynn, Gunn, Jocelyn A, O'Brien, Drane, Norris, Stephen H, Kelly, Terence A

“…A novel class of lymphocyte function-associated antigen-1 (LFA-1) inhibitors is described. Discovered during the process to improve the physicochemical and…”
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Thiabenzenes. VIII. One-electron reductions and disproportionations of thioxanthylium and 9-phenylthioxanthylium ion and a bithiabenzene analog by Price, Charles C, Siskin, Michael, Miao, Clara K

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Mercapto heterocyclic carboxylic acids, analogs of 3-mercaptopicolinic acid by Blank, Benjamin, DiTullio, Nicholas W, Owings, Franklin F, Deviney, Linda, Miao, Clara K, Saunders, Harry L

“…3-Mercaptopicolinic acid (3-MPA), a potent hypoglycemic agent in fasted rats, provided the impetus for substituting this compound with a 5-mercapto group (1),…”
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Mercaptopyridinecarboxylic acids. Synthesis and hypoglycemic activity by Blank, Benjamin, DiTullio, Nicholas W, Miao, Clara K, Owings, Franklin F, Gleason, John G, Ross, Stephen T, Berkoff, Charles E, Saunders, Harry L, Delarge, J, Lapiere, C. L

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Second-Generation Lymphocyte Function-Associated Antigen-1 Inhibitors:  1 H -Imidazo[1,2-α]imidazol-2-one Derivatives by Wu, Jiang-Ping, Emeigh, Jonathan, Gao, Donghong A., Goldberg, Daniel R., Kuzmich, Daniel, Miao, Clara, Potocki, Ian, Qian, Kevin C., Sorcek, Ronald J., Jeanfavre, Deborah D., Kishimoto, Kei, Mainolfi, Elizabeth A., Nabozny, Gerald, Peng, Charline, Reilly, Patricia, Rothlein, Robert, Sellati, Rosemarie H., Woska, Joseph R., Chen, Shirlynn, Gunn, Jocelyn A., O'Brien, Drane, Norris, Stephen H., Kelly, Terence A.

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Pyranenamines: a new series of antiallergic compounds by Snader, Kenneth M, Chakrin, Lawrence W, Cramer, Richard D, Gelernt, Yoshiko M, Miao, Clara K, Shah, Dinubai H, Venslavsky, Joseph W, Willis, Chester R, Sutton, Blaine M

“…Condensation of 3,5-diacylpyrantriones with various aromatic amines gave a new class of potent, orally active, antiallergic compounds, the…”
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Potential renin inhibitors. 2. Ethanolamine and ethylamine derivatives of phospholipids by Pfeiffer, Francis R, Miao, Clara K, Hoke, Suzanne C, Weisbach, Jerry A

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Lysophosphatidylethanolamine and 2-desoxylysophosphatidylethanolamine derivatives. 1. Potential renin inhibitors by Pfeiffer, Francis R, Hoke, Suzanne C, Miao, Clara K, Tedeschi, Ralph E, Pasternak, Josephine, Hahn, Richard, Erickson, Robert W, Levin, Herman W, Burton, Charlotte A, Weisbach, Jerry A

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Inhibition of human leukocyte elastase by N-substituted peptides containing .alpha.,.alpha.-difluorostatone residues at P1 by Skiles, Jerry W, Miao, Clara, Sorcek, Ronald, Jacober, Stephen, Mui, Philip W, Chow, Grace, Weldon, Steve M, Possanza, Genus, Skoog, Mark

“…A series of tripeptides which contain alpha,alpha-difluorostatone residues at P1-P1' and span the S3-S1' subsites have been shown to be potent inhibitors of…”
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GLC determination of ticrynafen and its metabolites in urine, serum, and plasma of humans and animals by Hwang, B, Konicki, G, Dewey, R, Miao, C

“…A sensitive GLC assay for ticrynafen, a diuretic agent with uricosuric properties, and its two metabolites in urine, serum, and plasma is described. The method…”
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Metabolism of 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline, a phenylethanolamine N-methyltransferase inhibitor. II. Species difference in metabolism and synthesis of its metabolites by Hwang, B Y, Kuo, G Y, Miao, C, Intoccia, A P

“…1. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (DCTQ), a potent reversible inhibitor of phenylethanolamine N-methyltransferase, was well absorbed, readily…”
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1,2-Diacyl-sn-glycerols and 2,3-diacyl-sn-glycerols by Pfeiffer, F R, Miao, C K, Weisbach, J A

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