Search Results - "Miano, Joseph M."

Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis by Miano, Joseph M., Fisher, Edward A., Majesky, Mark W.

“…Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell…”
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Myocardin in biology and disease by Miano, Joseph M

“…Myocardin （MYOCD） is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum…”
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Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like Phenotype by Vengrenyuk, Yuliya, Nishi, Hitoo, Long, Xiaochun, Ouimet, Mireille, Savji, Nazir, Martinez, Fernando O, Cassella, Courtney P, Moore, Kathryn J, Ramsey, Stephen A, Miano, Joseph M, Fisher, Edward A

“…OBJECTIVE—We previously showed that cholesterol loading in vitro converts mouse aortic vascular smooth muscle cells (VSMC) from a contractile state to one…”
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Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus by Miano, Joseph M, Long, Xiaochun, Fujiwara, Keigi

“…Serum response factor (SRF) is a highly conserved and widely expressed, single copy transcription factor that theoretically binds up to 1,216 permutations of a…”
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Identification and Initial Functional Characterization of a Human Vascular Cell–Enriched Long Noncoding RNA by Bell, Robert D, Long, Xiaochun, Lin, Mingyan, Bergmann, Jan H, Nanda, Vivek, Cowan, Sarah L, Zhou, Qian, Han, Yu, Spector, David L, Zheng, Deyou, Miano, Joseph M

“…OBJECTIVE—Long noncoding RNAs (lncRNAs) represent a rapidly growing class of RNA genes with functions related primarily to transcriptional and…”
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Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell Proliferation by Ballantyne, Margaret D, Pinel, Karine, Dakin, Rachel, Vesey, Alex T, Diver, Louise, Mackenzie, Ruth, Garcia, Raquel, Welsh, Paul, Sattar, Naveed, Hamilton, Graham, Joshi, Nikhil, Dweck, Marc R, Miano, Joseph M, McBride, Martin W, Newby, David E, McDonald, Robert A, Baker, Andrew H

“…BACKGROUND—Phenotypic switching of vascular smooth muscle cells from a contractile to a synthetic state is implicated in diverse vascular pathologies,…”
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Leiomodin 1, a New Serum Response Factor-dependent Target Gene Expressed Preferentially in Differentiated Smooth Muscle Cells by Nanda, Vivek, Miano, Joseph M.

“…Smooth muscle cell (SMC) differentiation is defined largely by a number of cell-restricted genes governed directly by the serum response factor (SRF)/myocardin…”
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short and long of noncoding sequences in the control of vascular cell phenotypes by Miano, Joseph M, Long, Xiaochun

“…The two principal cell types of importance for normal vessel wall physiology are smooth muscle cells and endothelial cells. Much progress has been made over…”
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MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function by Albinsson, Sebastian, Suarez, Yajaira, Skoura, Athanasia, Offermanns, Stefan, Miano, Joseph M, Sessa, William C

“…OBJECTIVE—Regulation of vascular smooth muscle (VSM) proliferation and contractile differentiation is an important factor in vascular development and…”
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miR-145 and miR-143 regulate smooth muscle cell fate and plasticity by Srivastava, Deepak, Cordes, Kimberly R, Sheehy, Neil T, White, Mark P, Berry, Emily C, Morton, Sarah U, Muth, Alecia N, Lee, Ting-Hein, Miano, Joseph M, Ivey, Kathryn N

“…MicroRNAs (miRNAs) are regulators of myriad cellular events, but evidence for a single miRNA that can efficiently differentiate multipotent stem cells into a…”
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Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression by Gao, Pan, Lyu, Qing, Ghanam, Amr R, Lazzarotto, Cicera R, Newby, Gregory A, Zhang, Wei, Choi, Mihyun, Slivano, Orazio J, Holden, Kevin, Walker, 2nd, John A, Kadina, Anastasia P, Munroe, Rob J, Abratte, Christian M, Schimenti, John C, Liu, David R, Tsai, Shengdar Q, Long, Xiaochun, Miano, Joseph M

“…Most single nucleotide variants (SNVs) occur in noncoding sequence where millions of transcription factor binding sites (TFBS) reside. Here, a comparative…”
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A Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells by Boulberdaa, Mounia, Scott, Elizabeth, Ballantyne, Margaret, Garcia, Raquel, Descamps, Betty, Angelini, Gianni D, Brittan, Mairi, Hunter, Amanda, McBride, Martin, McClure, John, Miano, Joseph M, Emanueli, Costanza, Mills, Nicholas L, Mountford, Joanne C, Baker, Andrew H

“…Despite the increasing importance of long noncoding RNA in physiology and disease, their role in endothelial biology remains poorly understood. Growing…”
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A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular Research by Miano, Joseph M, Zhu, Qiuyu Martin, Lowenstein, Charles J

“…Previous efforts to target the mouse genome for the addition, subtraction, or substitution of biologically informative sequences required complex vector design…”
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Myocardin regulates vascular smooth muscle cell inflammatory activation and disease by Ackers-Johnson, Matthew, Talasila, Amarnath, Sage, Andrew P, Long, Xiaochun, Bot, Ilze, Morrell, Nicholas W, Bennett, Martin R, Miano, Joseph M, Sinha, Sanjay

“…Atherosclerosis, the cause of 50% of deaths in westernized societies, is widely regarded as a chronic vascular inflammatory disease. Vascular smooth muscle…”
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CRISPR-Cas9 Genome Editing of a Single Regulatory Element Nearly Abolishes Target Gene Expression in Mice—Brief Report by Han, Yu, Slivano, Orazio J, Christie, Christine K, Cheng, Albert W, Miano, Joseph M

“…OBJECTIVE—To ascertain the importance of a single regulatory element in the control of Cnn1 expression using CRISPR/Cas9 (clustered regularly interspaced short…”
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Smooth Muscle Cell Genome Browser: Enabling the Identification of Novel Serum Response Factor Target Genes by Lee, Moon Young, Park, Chanjae, Berent, Robyn M, Park, Paul J, Fuchs, Robert, Syn, Hannah, Chin, Albert, Townsend, Jared, Benson, Craig C, Redelman, Doug, Shen, Tsai-Wei, Park, Jong Kun, Miano, Joseph M, Sanders, Kenton M, Ro, Seungil

“…Genome-scale expression data on the absolute numbers of gene isoforms offers essential clues in cellular functions and biological processes. Smooth muscle…”
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Omicron XBB.1.5 subvariant causes severe pulmonary disease in K18-hACE-2 mice by Elsharkawy, Amany, Stone, Shannon, Guglani, Anchala, Patterson, Lila D, Ge, Chunyu, Dim, Chinonye, Miano, Joseph M, Kumar, Mukesh

“…Owing to their continuous evolution, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) display disparate pathogenicity in…”
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CRISPR-Cas9–Mediated Epitope Tagging Provides Accurate and Versatile Assessment of Myocardin—Brief Report by Lyu, Qing, Dhagia, Vidhi, Han, Yu, Guo, Bing, Wines-Samuelson, Mary E, Christie, Christine K, Yin, Qiangzong, Slivano, Orazio J, Herring, Paul, Long, Xiaochun, Gupte, Sachin A, Miano, Joseph M

“…OBJECTIVE—Unreliable antibodies often hinder the accurate detection of an endogenous protein, and this is particularly true for the cardiac and smooth muscle…”
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Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function by Albinsson, Sebastian, Skoura, Athanasia, Yu, Jun, DiLorenzo, Annarita, Fernández-Hernando, Carlos, Offermanns, Stefan, Miano, Joseph M, Sessa, William C

“…Phenotypic modulation of smooth muscle cells (SMCs) plays a key role in vascular disease, including atherosclerosis. Several transcription factors have been…”
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Generating a CRISPR knockout mouse through a strong premature termination codon: a cautionary tale by Lyu, Qing Rex, Yao, Peng, Miano, Joseph M

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