Search Results - "Mfuh, Adelphe M."

Scalable, Metal- and Additive-Free, Photoinduced Borylation of Haloarenes and Quaternary Arylammonium Salts by Mfuh, Adelphe M, Doyle, John D, Chhetri, Bhuwan, Arman, Hadi D, Larionov, Oleg V

“…We report herein a simple, metal- and additive-free, photoinduced borylation of haloarenes, including electron-rich fluoroarenes, as well as arylammonium salts…”
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Additive- and Metal-Free, Predictably 1,2- and 1,3-Regioselective, Photoinduced Dual C–H/C–X Borylation of Haloarenes by Mfuh, Adelphe M, Nguyen, Vu T, Chhetri, Bhuwan, Burch, Jessica E, Doyle, John D, Nesterov, Vladimir N, Arman, Hadi D, Larionov, Oleg V

“…We report herein a simple, additive- and metal-free, photoinduced, dual C–H/C–X borylation of chloro-, bromo-, and iodoarenes. The reaction produces 1,2- and…”
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Concise Total Synthesis of Trichodermamides A, B, and C Enabled by an Efficient Construction of the 1,2-Oxazadecaline Core by Mfuh, Adelphe M, Zhang, Yu, Stephens, David E, Vo, Anh X. T, Arman, Hadi D, Larionov, Oleg V

“…We report herein a facile and efficient method of the construction of the cis-1,2-oxazadecaline system, distinctive of (pre)­trichodermamides, aspergillazine…”
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Identification of Inhibitors of CD36-Amyloid Beta Binding as Potential Agents for Alzheimer’s Disease by Doens, Deborah, Valiente, Pedro A, Mfuh, Adelphe M, X. T. Vo, Anh, Tristan, Adilia, Carreño, Lizmar, Quijada, Mario, Nguyen, Vu T, Perry, George, Larionov, Oleg V, Lleonart, Ricardo, Fernández, Patricia L

“…Neuroinflammation is one of the hallmarks of Alzheimer’s disease pathology. Amyloid β has a central role in microglia activation and the subsequent secretion…”
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Metal- and additive-free photoinduced borylation of haloarenes by Mfuh, Adelphe M, Schneider, Brett D, Cruces, Westley, Larionov, Oleg V

“…This protocol describes a simple, metal- and additive-free method to convert haloarenes directly to boronic acids and esters. These can be used to synthesize…”
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Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues by Jans, Petra E, Mfuh, Adelphe M, Arman, Hadi D, Shaffer, Corena V, Larionov, Oleg V, Mooberry, Susan L

“…The trichodermamides are modified dipeptides isolated from a wide variety of fungi, including Trichoderma virens. Previous studies reported that…”
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Accelerated Discovery of Carbamate Cbl‑b Inhibitors Using Generative AI Models and Structure-Based Drug Design by Quinn, Taylor R., Giblin, Kathryn A., Thomson, Clare, Boerth, Jeffrey A., Bommakanti, Gayathri, Braybrooke, Erin, Chan, Christina, Chinn, Alex J., Code, Erin, Cui, Caifeng, Fan, Yukai, Grimster, Neil P., Kohara, Keishi, Lamb, Michelle L., Ma, Lina, Mfuh, Adelphe M., Robb, Graeme R., Robbins, Kevin J., Schimpl, Marianne, Tang, Haoran, Ware, Jamie, Wrigley, Gail L., Xue, Lin, Zhang, Yun, Zhu, Huimin, Hughes, Samantha J.

“…Casitas B-lymphoma proto-oncogene-b (Cbl-b) is a RING finger E3 ligase that has an important role in effector T cell function, acting as a negative regulator…”
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Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl‑b Inhibitors by Mfuh, Adelphe M., Boerth, Jeffrey A., Bommakanti, Gayathri, Chan, Christina, Chinn, Alex J., Code, Erin, Fricke, Patrick J., Giblin, Kathryn A., Gohlke, Andrea, Hansel, Catherine, Hariparsad, Niresh, Hughes, Samantha J., Jin, Meizhong, Kantae, Vasudev, Kavanagh, Stefan L., Lamb, Michelle L., Lane, Jordan, Moore, Rachel, Puri, Taranee, Quinn, Taylor R., Reddy, Iswarya, Robb, Graeme R., Robbins, Kevin J., Gancedo Rodrigo, Miguel, Schimpl, Marianne, Singh, Baljinder, Singh, Meha, Tang, Haoran, Thomson, Clare, Walsh, Jarrod J., Ware, Jamie, Watson, Iain D. G., Ye, Min-Wei, Wrigley, Gail L., Zhang, Andrew X., Zhang, Yun, Grimster, Neil P.

“…Casitas B-lymphoma proto-oncogene-b (Cbl-b), a member of the Cbl family of RING finger E3 ubiquitin ligases, has been demonstrated to play a central role in…”
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Insights into the mechanistic and synthetic aspects of the Mo/P-catalyzed oxidation of N-heterocycles by Larionov, Oleg V, Stephens, David, Mfuh, Adelphe M, Arman, Hadi D, Naumova, Anastasia S, Chavez, Gabriel, Skenderi, Behije

“…A Mo/P catalytic system for an efficient gram-scale oxidation of a variety of nitrogen heterocycles to N-oxides with hydrogen peroxide as terminal oxidant has…”
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Discovery of a Novel Benzodiazepine Series of Cbl‑b Inhibitors for the Enhancement of Antitumor Immunity by Boerth, Jeffrey A., Chinn, Alex J., Schimpl, Marianne, Bommakanti, Gayathri, Chan, Christina, Code, Erin L., Giblin, Kathryn A., Gohlke, Andrea, Hansel, Catherine S., Jin, Meizhong, Kavanagh, Stefan L., Lamb, Michelle L., Lane, Jordan S., Larner, Carrie J. B., Mfuh, Adelphe M., Moore, Rachel K., Puri, Taranee, Quinn, Taylor R., Ye, Minwei, Robbins, Kevin J., Gancedo-Rodrigo, Miguel, Tang, Haoran, Walsh, Jarrod, Ware, Jamie, Wrigley, Gail L., Reddy, Iswarya Karapa, Zhang, Yun, Grimster, Neil P.

“…Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) is a RING finger E3 ligase that is responsible for repressing T-cell, natural killer (NK) cell, and B-cell…”
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Novel Asparagine-Derived Lipid Enhances Distearoylphosphatidylcholine Bilayer Resistance to Acidic Conditions by Mfuh, Adelphe M, Mahindaratne, Mathew P. D, Quintero, Maritza V, Lakner, Frederick J, Bao, Ande, Goins, Beth A, Phillips, William T, Negrete, George R

“…A novel asparagine-derived lipid analogue (ALA11,17) bearing a tetrahydropyrimidinone headgroup and two fatty chains (11 and 17 indicate the lengths of linear…”
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Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents by Mfuh, A M, Larionov, O V

“…Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory,…”
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