Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents

Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents

Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory, herbicidal, neuroprotective, and procognitive activities. The N-oxide motif has been successfully employed in a number of recent drug development proje...

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Bibliographic Details
Published in:Current medicinal chemistry Vol. 22; no. 24; p. 2819
Main Authors: Mfuh, A M, Larionov, O V
Format: Journal Article
Language:English
Published: United Arab Emirates 01-01-2015
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Anti-HIV Agents - pharmacology
Anti-HIV Agents - therapeutic use
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Cyclic N-Oxides - pharmacology
Cyclic N-Oxides - therapeutic use
Fibrinolytic Agents - pharmacology
Fibrinolytic Agents - therapeutic use
Herbicides - pharmacology
Humans
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Protein Kinase Inhibitors - pharmacology
Protein Kinase Inhibitors - therapeutic use
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Summary:Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory, herbicidal, neuroprotective, and procognitive activities. The N-oxide motif has been successfully employed in a number of recent drug development projects. This review surveys the emergence of this scaffold in the mainstream medicinal chemistry with a focus on the discovery of the heterocyclic N-oxide drugs, N-oxide-specific mechanisms of action, drug-receptor interactions and synthetic avenues to these compounds. As the first review on this subject that covers the developments since 1950s to date, it is expected that it will inspire wider implementation of the heterocyclic N-oxide motif in the rational design of new medicinal agents.
ISSN:1875-533X
DOI:10.2174/0929867322666150619104007