β-Endorphin expression in gross cystic breast disease

β-Endorphin expression in gross cystic breast disease

Opioid peptides have a variety of pathophysiologic actions, playing a novel important role in human breast cancer. The expression of β-endorphin was studied in 84 human breast cyst fluids from gross cystic breast disease-affected patients. The concentration of β-endorphin in pooled breast cyst fluid...

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Bibliographic Details
Published in:Cancer letters Vol. 89; no. 2; pp. 189 - 193
Main Authors: Mannello, F., Bocchiotti, G.D., Mezzolani, M.P., Gazzanelli, G.
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 02-03-1995
Elsevier
Subjects:
Adult
beta-Endorphin - metabolism
Biological and medical sciences
Breast cyst fluid
Electrolytes
Female
Fibrocystic Breast Disease - metabolism
Gross cystic breast disease
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Middle Aged
Opioid peptides
Radioimmunoassay
Tumors
β-Endorphin
Electrolytes
Gross cystic breast disease
Opioid peptides
Breast cyst fluid
β-Endorphin
Human
Mammary gland diseases
Fibrocystic mastitis
Pathogenesis
Tumor
Mammary gland
Carcinogenesis
In vitro
Cystic fluid
Opioid peptide
Quantitative analysis
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Description
Summary:Opioid peptides have a variety of pathophysiologic actions, playing a novel important role in human breast cancer. The expression of β-endorphin was studied in 84 human breast cyst fluids from gross cystic breast disease-affected patients. The concentration of β-endorphin in pooled breast cyst fluids was over four-fold higher than in respective plasma with a significant increase in the mean value of the ‘metabolically active’ apocrine cysts when compared with flattened cysts ( P < 0.001). The higher levels of Type I cyst suggest de novo mammary synthesis of endogenous opioid peptides and could represent an altered expression of biosynthetic activity of apocrine breast cells, providing a possible explanation on functional changes of gross cysts, on the mechanism of their formation and a perspective relationship to breast cancer risk.
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ISSN:0304-3835
1872-7980
DOI:10.1016/0304-3835(94)03669-A