Antiulcerative properties of bovine α-lactalbumin

Antiulcerative properties of bovine α-lactalbumin

The capacity of α-lactalbumin to protect the rat stomach mucosa against ulcerative lesions caused by indomethacin or absolute ethanol was investigated. An α-lactalbumin prepared in the laboratory by anion exchange and molecular exclusion chromatography (Lab. α-La) and a commercial α-lactalbumin (Com...

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Bibliographic Details
Published in:International dairy journal Vol. 16; no. 9; pp. 1005 - 1012
Main Authors: Mezzaroba, L.F.H., Carvalho, J.E., Ponezi, A.N., Antônio, M.A., Monteiro, K.M., Possenti, A., Sgarbieri, V.C.
Format: Journal Article Conference Proceeding
Language:English
Published: Oxford Elsevier Ltd 01-09-2006
Elsevier Science
Subjects:
Biological and medical sciences
Ethanol
Food industries
Fundamental and applied biological sciences. Psychology
Indomethacin
Milk and cheese industries. Ice creams
Ulcerogenesis
α-Lactalbumin
Ulcerogenesis
α-Lactalbumin
Indomethacin
Ethanol
Bovine
Milk protein
Vertebrata
Mammalia
Lactalbumin
Dairy industry
Artiodactyla
Whey protein
Ungulata
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Summary:The capacity of α-lactalbumin to protect the rat stomach mucosa against ulcerative lesions caused by indomethacin or absolute ethanol was investigated. An α-lactalbumin prepared in the laboratory by anion exchange and molecular exclusion chromatography (Lab. α-La) and a commercial α-lactalbumin (Comm. α-La) were compared with a saline control. Comm. α-La offered 44% protection versus Lab. α-La 12%, in the indomethacin model. For absolute ethanol, no statistical difference was found in the inhibition of the development of ulcerative lesions for the two α-lactalbumins, ranging from 32% to 50%. The content of prostaglandin E 2 (PGE 2) and mucus increased in the mucosa after α-La intubation, suggesting that the protein protects the mucosa via stimulation of PGE 2 and mucus production. Blocking free sulfhydryl groups by in vivo N-ethylmaleimide alkylation caused an increase in mucosal ulcerative lesions, suggesting the importance of sulfhydryl compounds in the gastric mucosa protection.
ISSN:0958-6946
1879-0143
DOI:10.1016/j.idairyj.2005.10.027