Search Results - "Mezhenskaya, Daria"

M2e-based universal influenza vaccines: a historical overview and new approaches to development by Mezhenskaya, Daria, Isakova-Sivak, Irina, Rudenko, Larisa

“…The influenza A virus was isolated for the first time in 1931, and the first attempts to develop a vaccine against the virus began soon afterwards. In addition…”
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Broadly protective anti-hemagglutinin stalk antibodies induced by live attenuated influenza vaccine expressing chimeric hemagglutinin by Isakova-Sivak, Irina, Korenkov, Daniil, Smolonogina, Tatiana, Kotomina, Tatiana, Donina, Svetlana, Matyushenko, Victoria, Mezhenskaya, Daria, Krammer, Florian, Rudenko, Larisa

“…The development of influenza vaccines that can provide broad protection against all drifted seasonal virus variants, zoonotic infections and emerging pandemic…”
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Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin by Park, Bo Ryoung, Kim, Ki-Hye, Kotomina, Tatiana, Kim, Min-Chul, Kwon, Young-Man, Jeeva, Subbiah, Jung, Yu-Jin, Bhatnagar, Noopur, Isakova-Sivak, Irina, Mezhenskaya, Daria, Rudenko, Larisa, Wang, Bao-Zhong, Kang, Sang-Moo

“…Hemagglutinin (HA)-based current vaccines provide suboptimum cross protection. Influenza A virus contains an ion channel protein M2 conserved extracellular…”
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Expression of the SARS-CoV-2 receptor-binding domain by live attenuated influenza vaccine virus as a strategy for designing a bivalent vaccine against COVID-19 and influenza by Stepanova, Ekaterina, Isakova-Sivak, Irina, Mezhenskaya, Daria, Niskanen, Sergei, Matyushenko, Victoria, Bazhenova, Ekaterina, Rak, Alexandra, Wong, Pei Fong, Prokopenko, Polina, Kotomina, Tatiana, Krutikova, Elena, Legotskiy, Sergei, Neterebskii, Bogdan, Ostroukhova, Tatiana, Sivak, Konstantin, Orshanskaya, Yana, Yakovlev, Kirill, Rudenko, Larisa

“…Influenza and SARS-CoV-2 are two major respiratory pathogens that cocirculate in humans and cause serious illness with the potential to exacerbate disease in…”
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Ferristatin II Efficiently Inhibits SARS-CoV-2 Replication in Vero Cells by Sokolov, Alexey, Isakova-Sivak, Irina, Grudinina, Natalia, Mezhenskaya, Daria, Litasova, Elena, Kostevich, Valeria, Stepanova, Ekaterina, Rak, Alexandra, Sychev, Ivan, Kirik, Olga, Rudenko, Larisa

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to have a significant impact on global public health. Multiple mechanisms for SARS-CoV-2…”
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Universal Live-Attenuated Influenza Vaccine Candidates Expressing Multiple M2e Epitopes Protect Ferrets against a High-Dose Heterologous Virus Challenge by Mezhenskaya, Daria, Isakova-Sivak, Irina, Matyushenko, Victoria, Donina, Svetlana, Rekstin, Andrey, Sivak, Konstantin, Yakovlev, Kirill, Katelnikova, Anastasia, Kryshen, Kirill, Makarov, Valery, Rudenko, Larisa

“…The development of an influenza vaccine with broad protection and durability remains an attractive idea due to the high mutation rate of the influenza virus…”
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RDE Treatment Prevents Non-Specific Detection of SARS-CoV-2- and Influenza-Specific IgG Antibodies in Heat-Inactivated Serum Samples by Goshina, Arina, Matyushenko, Victoria, Mezhenskaya, Daria, Rak, Alexandra, Katelnikova, Anastasia, Gusev, Denis, Rudenko, Larisa, Isakova-Sivak, Irina

“…Assessing the levels of serum IgG antibodies is widely used to measure immunity to influenza and the new severe acute respiratory syndrome coronavirus 2…”
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Development of a T Cell-Based COVID-19 Vaccine Using a Live Attenuated Influenza Vaccine Viral Vector by Isakova-Sivak, Irina, Stepanova, Ekaterina, Matyushenko, Victoria, Niskanen, Sergei, Mezhenskaya, Daria, Bazhenova, Ekaterina, Krutikova, Elena, Kotomina, Tatiana, Prokopenko, Polina, Neterebskii, Bogdan, Doronin, Aleksandr, Vinogradova, Elena, Yakovlev, Kirill, Sivak, Konstantin, Rudenko, Larisa

“…The COVID-19 pandemic emerged in 2020 and has caused an unprecedented burden to all countries in the world. SARS-CoV-2 continues to circulate and antigenically…”
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Safety and Immunogenicity Study of a Bivalent Vaccine for Combined Prophylaxis of COVID-19 and Influenza in Non-Human Primates by Stepanova, Ekaterina, Isakova-Sivak, Irina, Matyushenko, Victoria, Mezhenskaya, Daria, Kudryavtsev, Igor, Kostromitina, Arina, Chistiakova, Anna, Rak, Alexandra, Bazhenova, Ekaterina, Prokopenko, Polina, Kotomina, Tatiana, Donina, Svetlana, Novitskaya, Vlada, Sivak, Konstantin, Karal-Ogly, Dzhina, Rudenko, Larisa

“…Influenza and SARS-CoV-2 viruses are two highly variable pathogens. We have developed a candidate bivalent live vaccine based on the strain of licensed…”
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A Live Probiotic Vaccine Prototype Based on Conserved Influenza a Virus Antigens Protect Mice against Lethal Influenza Virus Infection by Mezhenskaya, Daria, Isakova-Sivak, Irina, Gupalova, Tatiana, Bormotova, Elena, Kuleshevich, Eugenia, Kramskaya, Tatiana, Leontieva, Galina, Rudenko, Larisa, Suvorov, Alexander

“…Background: Due to the highly variable nature of the antigenic properties of the influenza virus, many efforts have been made to develop broadly reactive…”
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Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge by Isakova-Sivak, Irina, Matyushenko, Victoria, Kotomina, Tatiana, Kiseleva, Irina, Krutikova, Elena, Donina, Svetlana, Rekstin, Andrey, Larionova, Natalia, Mezhenskaya, Daria, Sivak, Konstantin, Muzhikyan, Arman, Katelnikova, Anastasia, Rudenko, Larisa

“…The development of universal influenza vaccines has been a priority for more than 20 years. We conducted a preclinical study in ferrets of two sets of live…”
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Generation and Characterization of Universal Live-Attenuated Influenza Vaccine Candidates Containing Multiple M2e Epitopes by Kotomina, Tatiana, Isakova-Sivak, Irina, Kim, Ki-Hye, Park, Bo Ryoung, Jung, Yu-Jin, Lee, Youri, Mezhenskaya, Daria, Matyushenko, Victoria, Kang, Sang-Moo, Rudenko, Larisa

“…Influenza viruses constantly evolve, reducing the overall protective effect of routine vaccination campaigns. Many different strategies are being explored to…”
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Construction and Immunogenicity of a Novel Multivalent Vaccine Prototype Based on Conserved Influenza Virus Antigens by Kirsteina, Anna, Akopjana, Inara, Bogans, Janis, Lieknina, Ilva, Jansons, Juris, Skrastina, Dace, Kazaka, Tatjana, Tars, Kaspars, Isakova-Sivak, Irina, Mezhenskaya, Daria, Kotomina, Tatiana, Matyushenko, Victoria, Rudenko, Larisa, Kazaks, Andris

“…Influenza, an acute, highly contagious respiratory disease, remains a significant threat to public health. More effective vaccination strategies aimed at…”
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A Strategy to Elicit M2e-Specific Antibodies Using a Recombinant H7N9 Live Attenuated Influenza Vaccine Expressing Multiple M2e Tandem Repeats by Mezhenskaya, Daria, Isakova-Sivak, Irina, Kotomina, Tatiana, Matyushenko, Victoria, Kim, Min-Chul, Bhatnagar, Noopur, Kim, Ki-Hye, Kang, Sang-Moo, Rudenko, Larisa

“…Influenza viruses remain a serious public health problem. Vaccination is the most effective way to prevent the disease; however, seasonal influenza vaccines…”
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Recombinant Live Attenuated Influenza Vaccine Viruses Carrying Conserved T-cell Epitopes of Human Adenoviruses Induce Functional Cytotoxic T-Cell Responses and Protect Mice against Both Infections by Isakova-Sivak, Irina, Matyushenko, Victoria, Stepanova, Ekaterina, Matushkina, Anastasia, Kotomina, Tatiana, Mezhenskaya, Daria, Prokopenko, Polina, Kudryavtsev, Igor, Kopeykin, Pavel, Sivak, Konstantin, Rudenko, Larisa

“…Human adenoviruses (AdVs) are one of the most common causes of acute respiratory viral infections worldwide. Multiple AdV serotypes with low cross-reactivity…”
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Yeast red pigment modifies Amyloid beta growth in Alzheimer disease models in both Saccharomyces cerevisiae and Drosophila melanogaster by Nevzglyadova, Olga V., Mikhailova, Ekaterina V., Amen, Triana R., Zenin, Valeriy V., Artemov, Alexey V., Kostyleva, Elena I., Mezhenskaya, Daria A., Rodin, Dmitry I., Saifitdinova, Alsu F., Khodorkovskii, Mikhail A., Sarantseva, Svetlana V., Soidla, Tonu R.

“…Abstract The effect of yeast red pigment on amyloid-β (Aβ) aggregation and fibril growth was studied in yeasts, fruit flies and in vitro. Yeast strains…”
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Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augment influenza-specific resident memory T-cell responses by Matyushenko, Victoria, Kotomina, Tatiana, Kudryavtsev, Igor, Mezhenskaya, Daria, Prokopenko, Polina, Matushkina, Anastasia, Sivak, Konstantin, Muzhikyan, Arman, Rudenko, Larisa, Isakova-Sivak, Irina

“…Respiratory syncytial virus (RSV) can cause recurrent infection in people because it does not stimulate a long-lived immunological memory. There is an urgent…”
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Influenza vaccine: progress in a vaccine that elicits a broad immune response by Isakova-Sivak, Irina, Stepanova, Ekaterina, Mezhenskaya, Daria, Matyushenko, Victoria, Prokopenko, Polina, Sychev, Ivan, Wong, Pei-Fong, Rudenko, Larisa

“…The licensed seasonal influenza vaccines predominantly induce neutralizing antibodies against immunodominant hypervariable epitopes of viral surface proteins,…”
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