Search Results - "Mezeiova, E."

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease by Hepnarova, V., Korabecny, J., Matouskova, L., Jost, P., Muckova, L., Hrabinova, M., Vykoukalova, N., Kerhartova, M., Kucera, T., Dolezal, R., Nepovimova, E., Spilovska, K., Mezeiova, E., Pham, N.L., Jun, D., Staud, F., Kaping, D., Kuca, K., Soukup, O.

“…Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed based on multi-target directed ligands (MTLDs) paradigm, synthesized and…”
Get full text

UHPLC-HRMS study of pharmacokinetics of a novel hybrid cholinesterase inhibitor K1234: A comparison between in silico, in vitro and in vivo data by Mzik, M., Sestak, V., Mezeiova, E., Korabecny, J., Hroch, M., Pejchal, J., Karasova-Zdarova, J.

“…Alzheimer's disease (AD) is one of the most common forms of dementia. Current anti-AD therapeutics exploit the cholinergic hypothesis of its pathophysiology;…”
Get full text

Non-peptide orexin 2 receptor modulators as promising way to treatment of narcolepsy/insomnia by Janockova, J., Kobrlova, T., Mezeiova, E., Dolezal, R., Korabecny, J., Soukup, O.

Get full text

1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats by Zdarova Karasova, Jana, Sestak, Vit, Korabecny, Jan, Mezeiova, Eva, Palicka, Vladimir, Kuca, Kamil, Mzik, Martin

“…•We present a validated UHPLC-HRMS method used for pharmacokinetic analysis of donepezil and its three structural “fragments”.•One of the fragments accumulates…”
Get full text

P.760 Effects of novel cholinesterase inhibitors on mitochondrial respiration and MAO activity - in vitro study by Hroudová, J., Korábečný, J., Špilovská, K., Mezeiová, E., Górecki, L., Maliňák, D., Fišar, Z.

Get full text

P.5.a.001 - In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration by Hroudová, J., Fišar, Z., Korábečny, J., Nepovímová, E., Spilovská, K., Vašková, L., Mezeiová, E., Musílek, K., Kuča, K., Raboch, J.

Get full text

In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration by Hroudová, J., Fišar, Z., Korábečny, J., Nepovímová, E., Spilovská, K., Vašková, L., Mezeiová, E., Musílek, K., Kuča, K., Raboch, J.

Get full text