Search Results - "Meyre, D."

Ethnic and population differences in the genetic predisposition to human obesity by Stryjecki, C., Alyass, A., Meyre, D.

“…Summary Obesity rates have escalated to the point of a global pandemic with varying prevalence across ethnic groups. These differences are partially explained…”
Get full text

Is FTO a type 2 diabetes susceptibility gene? by Meyre, D.

Get full text

A systematic review of genetic syndromes with obesity by Kaur, Y., Souza, R. J., Gibson, W. T., Meyre, D.

“…Summary Syndromic monogenic obesity typically follows Mendelian patterns of inheritance and involves the co‐presentation of other characteristics, such as…”
Get full text

Challenges in reproducibility of genetic association studies: lessons learned from the obesity field by Li, A, Meyre, D

“…A robust replication of initial genetic association findings has proved to be difficult in human complex diseases and more specifically in the obesity field…”
Get full text

On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations by Qasim, A., Turcotte, M., Souza, R. J., Samaan, M. C., Champredon, D., Dushoff, J., Speakman, J. R., Meyre, D.

“…Summary Genetic predisposition to obesity presents a paradox: how do genetic variants with a detrimental impact on human health persist through evolutionary…”
Get full text

Established and emerging strategies to crack the genetic code of obesity by Tam, V., Turcotte, M., Meyre, D.

“…Summary Tremendous progress has been made in the genetic elucidation of obesity over the past two decades, driven largely by technological, methodological and…”
Get full text

Revisiting the evolutionary origins of obesity: lazy versus peppy‐thrifty genotype hypothesis by Reddon, H., Patel, Y., Turcotte, M., Pigeyre, M., Meyre, D.

“…Summary The recent global obesity epidemic is attributed to major societal and environmental changes, such as excessive energy intake and sedentary lifestyle…”
Get full text

The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression by Samaan, Z, Anand, S, Zhang, X, Desai, D, Rivera, M, Pare, G, Thabane, L, Xie, C, Gerstein, H, Engert, J C, Craig, I, Cohen-Woods, S, Mohan, V, Diaz, R, Wang, X, Liu, L, Corre, T, Preisig, M, Kutalik, Z, Bergmann, S, Vollenweider, P, Waeber, G, Yusuf, S, Meyre, D

“…Candidate gene and genome-wide association studies have not identified common variants, which are reliably associated with depression. The recent…”
Get full text

Obesity genetics: insights from the Pakistani population by Pigeyre, M., Saqlain, M., Turcotte, M., Raja, G. K., Meyre, D.

“…Summary The Pakistani population is extensively diverse, indicating a genetic admixture of European and Central/West Asian migrants with indigenous South Asian…”
Get full text

A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity by Philippe, J, Stijnen, P, Meyre, D, De Graeve, F, Thuillier, D, Delplanque, J, Gyapay, G, Sand, O, Creemers, J W, Froguel, P, Bonnefond, A

“…Background: A significant proportion of severe familial forms of obesity remain genetically elusive. Taking advantage of our unique cohort of multigenerational…”
Get full text

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population by Robiou-du-Pont, S, Bonnefond, A, Yengo, L, Vaillant, E, Lobbens, S, Durand, E, Weill, J, Lantieri, O, Balkau, B, Charpentier, G, Marre, M, Froguel, P, Meyre, D

“…Context: Obesity is the major determinant of type 2 diabetes (T2D), presumably through its effect on insulin resistance. Genome-wide association studies…”
Get full text

Gain‐of‐function variants in the melanocortin 4 receptor gene confer susceptibility to binge eating disorder in subjects with obesity: a systematic review and meta‐analysis by Qasim, A., Mayhew, A. J., Ehtesham, S., Alyass, A., Volckmar, A.‐L., Herpertz, S., Hinney, A., Hebebrand, J., Meyre, D.

“…Summary The association between coding variants in the melanocortin 4 receptor gene (MC4R) and binge eating disorder (BED) in patients with obesity is…”
Get full text

The association of attempted suicide with genetic variants in the SLC6A4 and TPH genes depends on the definition of suicidal behavior: a systematic review and meta-analysis by Clayden, R C, Zaruk, A, Meyre, D, Thabane, L, Samaan, Z

“…The global prevalence of suicide has increased substantially over the last four decades. Suicidal behavior manifests owing to a combination of biological,…”
Get full text

Parental and child genetic contributions to obesity traits in early life based on 83 loci validated in adults: the FAMILY study by Li, A., Robiou‐du‐Pont, S., Anand, S. S., Morrison, K. M., McDonald, S. D., Atkinson, S. A., Teo, K. K., Meyre, D.

“…Summary Background The genetic influence on child obesity has not been fully elucidated. Objective This study investigated the parental and child contributions…”
Get full text

Lack of association between type 2 diabetes and major depression: epidemiologic and genetic evidence in a multiethnic population by Samaan, Z, Garasia, S, Gerstein, H C, Engert, J C, Mohan, V, Diaz, R, Anand, S S, Meyre, D

“…The positive association between depression and type 2 diabetes (T2D) has been controversial, and little is known about the molecular determinants linking…”
Get full text

Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study by Lamri, A, Bonnefond, A, Meyre, D, Balkau, B, Roussel, R, Marre, M, Froguel, P, Fumeron, F

“…Abstract Background and aims GPR120 (encoded by FFAR4 ) is a lipid sensor that plays an important role in the control of energy balance. GPR120 is activated by…”
Get full text

Common genetic variation near MC4R is associated with eating behaviour patterns in European populations by Stutzmann, F, Cauchi, S, Durand, E, Calvacanti-Proenca, C, Pigeyre, M, Hartikainen, A.L, Sovio, U, Tichet, J, Marre, M, Weill, J, Balkau, B, Potoczna, N, Laitinen, J, Elliott, P, Jarvelin, M.R, Horber, F

“…Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI)…”
Get full text

APOA5 and APOA1 polymorphisms are associated with triglyceride levels in Mexican children by Suárez‐Sánchez, F., Klunder‐Klunder, M., Valladares‐Salgado, A., Gómez‐Zamudio, J., Peralta‐Romero, J., Meyre, D., Burguete‐García, A., Cruz, M.

“…Summary Background Dyslipidemia is an important risk factor for the development of several diseases. The genetic component of hypertriglyceridemia has been…”
Get full text

Empirical evaluation of the Q-Genie tool: a protocol for assessment of effectiveness by Sohani, Z N, Sarma, S, Alyass, A, de Souza, R J, Robiou-du-Pont, S, Li, A, Mayhew, A, Yazdi, F, Reddon, H, Lamri, A, Stryjecki, C, Ishola, A, Lee, Y K, Vashi, N, Anand, S S, Meyre, D

“…IntroductionMeta-analyses of genetic association studies are affected by biases and quality shortcomings of the individual studies. We previously developed and…”
Get full text

R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population by Meyre, David, Farge, Morgane, Lecoeur, Cécile, Proenca, Christine, Durand, Emmanuelle, Allegaert, Frédéric, Tichet, Jean, Marre, Michel, Balkau, Beverley, Weill, Jacques, Delplanque, Jérôme, Froguel, Philippe

“…Stone et al. previously reported an association between the TBC1D1 gene variant R125W (rs35859249) and severe obesity in women from US pedigrees. We attempted…”
Get full text