Search Results - "Meylan, Françoise"

JAK inhibitors: Ten years after by Spinelli, Francesca Romana, Meylan, Françoise, O'Shea, John J., Gadina, Massimo

“…The European Journal of Immunology was launched 50 years ago, coinciding with the discovery of many cytokines and growth factors and the emergence of an…”
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The ever-expanding role of cytokine receptor DR3 in T cells by Liman, Nurcin, Lanasa, Dominic, Meylan, Françoise, Park, Jung-Hyun

“…•Both proapoptotic and proinflammatory effects are attributed to DR3 activation.•DR3 signaling in Foxp3+ Treg cells drives their expansion and effector…”
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TNF superfamily cytokines in the promotion of Th9 differentiation and immunopathology by Meylan, Françoise, Siegel, Richard M.

“…The tumor necrosis factor (TNF) receptors and their corresponding cytokine ligands have been implicated in many aspects of the biology of immune functions. TNF…”
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TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation by Meylan, Françoise, Richard, Arianne C., Siegel, Richard M.

“…DR3 (TNFRSF25) is a member of the tumor necrosis factor receptor (TNFR) superfamily expressed primarily on lymphocytes and is a receptor for the TNF family…”
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Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4 by Gomez-Rodriguez, Julio, Meylan, Françoise, Handon, Robin, Hayes, Erika T., Anderson, Stacie M., Kirby, Martha R., Siegel, Richard M., Schwartzberg, Pamela L.

“…Th9 cells produce interleukin (IL)-9, a cytokine implicated in allergic asthma and autoimmunity. Here we show that Itk, a mediator of T cell receptor…”
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T Cell Receptor and Co-Stimulatory Signals for Th9 Generation by Meylan, Françoise, Gomez-Rodriguez, Julio

“…In vitro polarization of naïve CD4 T cells toward distinct T helper lineages is crucial for establishing the factors and features that determine the…”
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Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells by Gomez-Rodriguez, Julio, Wohlfert, Elizabeth A, Handon, Robin, Meylan, Françoise, Wu, Julie Z, Anderson, Stacie M, Kirby, Martha R, Belkaid, Yasmine, Schwartzberg, Pamela L

“…A proper balance between Th17 and T regulatory cells (Treg cells) is critical for generating protective immune responses while minimizing autoimmunity. We show…”
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Somatic activating mutations in MAP2K1 cause melorheostosis by Kang, Heeseog, Jha, Smita, Deng, Zuoming, Fratzl-Zelman, Nadja, Cabral, Wayne A., Ivovic, Aleksandra, Meylan, Françoise, Hanson, Eric P., Lange, Eileen, Katz, James, Roschger, Paul, Klaushofer, Klaus, Cowen, Edward W., Siegel, Richard M., Marini, Joan C., Bhattacharyya, Timothy

“…Melorheostosis is a sporadic disease of uncertain etiology characterized by asymmetric bone overgrowth and functional impairment. Using whole exome sequencing,…”
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Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells by Ferdinand, John R, Richard, Arianne C, Meylan, Françoise, Al-Shamkhani, Aymen, Siegel, Richard M

“…TNF superfamily cytokines play major roles in the regulation of adaptive and innate immunity. The TNF superfamily cytokine TL1A (TNFSF15), through its cognate…”
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Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease by Richard, Arianne C, Peters, James E, Savinykh, Natalia, Lee, James C, Hawley, Eric T, Meylan, Françoise, Siegel, Richard M, Lyons, Paul A, Smith, Kenneth G C

“…Chronic inflammation in inflammatory bowel disease (IBD) results from a breakdown of intestinal immune homeostasis and compromise of the intestinal barrier…”
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The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells by Luo, Shunqun, Liman, Nurcin, Li, Can, Crossman, Assiatu, Wang, Eddie C. Y., Meylan, Françoise, Park, Jung-Hyun

“…Invariant natural killer T ( i NKT) cells correspond to a population of thymus-generated T cells with innate-like characteristics and effector functions. Among…”
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Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction by Cruz, Anthony C., Ramaswamy, Madhu, Ouyang, Claudia, Klebanoff, Christopher A., Sengupta, Prabuddha, Yamamoto, Tori N., Meylan, Françoise, Thomas, Stacy K., Richoz, Nathan, Eil, Robert, Price, Susan, Casellas, Rafael, Rao, V. Koneti, Lippincott-Schwartz, Jennifer, Restifo, Nicholas P., Siegel, Richard M.

“…Mutations affecting the apoptosis-inducing function of the Fas/CD95 TNF-family receptor result in autoimmune and lymphoproliferative disease. However, Fas can…”
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Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation by Laurence, Arian, Tato, Cristina M., Davidson, Todd S., Kanno, Yuka, Chen, Zhi, Yao, Zhengju, Blank, Rebecca B., Meylan, Françoise, Siegel, Richard, Hennighausen, Lothar, Shevach, Ethan M., O'Shea, John J.

“…Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the…”
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The TNF‐family cytokine TL1A: from lymphocyte costimulator to disease co‐conspirator by Richard, Arianne C., Ferdinand, John R., Meylan, Francoise, Hayes, Erika T., Gabay, Odile, Siegel, Richard M.

“…Review on the TNF‐family cytokine TL1A in physiological and pathological immune responses. Originally described in 2002 as a T cell‐costimulatory cytokine, the…”
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The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells by Richard, Arianne C, Tan, Cuiyan, Hawley, Eric T, Gomez-Rodriguez, Julio, Goswami, Ritobrata, Yang, Xiang-Ping, Cruz, Anthony C, Penumetcha, Pallavi, Hayes, Erika T, Pelletier, Martin, Gabay, Odile, Walsh, Matthew, Ferdinand, John R, Keane-Myers, Andrea, Choi, Yongwon, O'Shea, John J, Al-Shamkhani, Aymen, Kaplan, Mark H, Gery, Igal, Siegel, Richard M, Meylan, Françoise

“…The TNF family cytokine TL1A (Tnfsf15) costimulates T cells and type 2 innate lymphocytes (ILC2) through its receptor DR3 (Tnfrsf25). DR3-deficient mice have…”
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The TNF-Family Receptor DR3 is Essential for Diverse T Cell-Mediated Inflammatory Diseases by Meylan, Françoise, Davidson, Todd S., Kahle, Erin, Kinder, Michelle, Acharya, Krishika, Jankovic, Dragana, Bundoc, Virgilio, Hodges, Marcus, Shevach, Ethan M., Keane-Myers, Andrea, Wang, Eddie C.Y., Siegel, Richard M.

“…DR3 (TRAMP, LARD, WSL-1, TNFRSF25) is a death-domain-containing tumor necrosis factor (TNF)-family receptor primarily expressed on T cells. TL1A, the…”
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Distribution and Functional Consequences of Somatic MAP2K1 Variants in Affected Skin Associated with Bone Lesions in Melorheostosis by Jha, Smita, Ivovic, Aleksandra, Kang, Heeseog, Meylan, Françoise, Hanson, Eric P., Rimland, Casey, Lange, Eileen, Katz, James, McBride, Alison, Warner, Andrew C., Edmondson, Elijah F., Cowen, Edward W., Marini, Joan C., Siegel, Richard M., Bhattacharyya, Timothy

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Correction: The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell-Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9-Producing T Cells by Richard, Arianne C, Tan, Cuiyan, Hawley, Eric T, Gomez-Rodriguez, Julio, Goswami, Ritobrata, Yang, Xiang-Ping, Cruz, Anthony C, Penumetcha, Pallavi, Hayes, Erika T, Pelletier, Martin, Gabay, Odile, Walsh, Matthew, Ferdinand, John R, Keane-Myers, Andrea, Choi, Yongwon, O'Shea, John J, Al-Shamkhani, Aymen, Kaplan, Mark H, Gery, Igal, Siegel, Richard M, Meylan, Françoise

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Negative thymocyte selection to HERV-K18 superantigens in humans by Meylan, Françoise, De Smedt, Magda, Leclercq, Georges, Plum, Jean, Leupin, Olivier, Marguerat, Samuel, Conrad, Bernard

“…An experimental system to explore central tolerance in humans is unavailable. However, the human endogenous retrovirus K-18 (HERV-K18) region on chromosome 1…”
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MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23 by Mikami, Yohei, Philips, Rachael L., Sciumè, Giuseppe, Petermann, Franziska, Meylan, Françoise, Nagashima, Hiroyuki, Yao, Chen, Davis, Fred P., Brooks, Stephen R., Sun, Hong-Wei, Takahashi, Hayato, Poholek, Amanda C., Shih, Han-Yu, Afzali, Behdad, Muljo, Stefan A., Hafner, Markus, Kanno, Yuka, O’Shea, John J.

“…MicroRNAs are important regulators of immune responses. Here, we show miR-221 and miR-222 modulate the intestinal Th17 cell response. Expression of miR-221 and…”
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