Search Results - "Meyers, Severien"
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Coagulation: At the heart of infective endocarditis
Published in Journal of thrombosis and haemostasis (01-05-2020)“…Infective endocarditis is a life‐threatening and enigmatic disease with a mortality of 30% and a pathophysiology that is poorly understood. However, at its…”
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Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves
Published in European heart journal (14-10-2019)“…Abstract Aims The pathogenesis of endocarditis is not well understood resulting in unsuccessful attempts at prevention. Clinical observations suggest that…”
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An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis
Published in eLife (09-06-2020)“…Energy-coupling factor type transporters (ECF) represent trace nutrient acquisition systems. Substrate binding components of ECF-transporters are membrane…”
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Staphylococcus aureus and Neutrophil Extracellular Traps: The Master Manipulator Meets Its Match in Immunothrombosis
Published in Arteriosclerosis, thrombosis, and vascular biology (01-03-2022)“…Over the past 10 years, neutrophil extracellular traps (NETs) have become widely accepted as an integral player in immunothrombosis, due to their complex…”
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Staphylococcus aureus and Neutrophil Extracellular Traps: The Master Manipulator Meets Its Match in Immunothrombosis
Published in Arteriosclerosis, thrombosis, and vascular biology (03-02-2022)“…Over the past 10 years, neutrophil extracellular traps (NETs) have become widely accepted as an integral player in immunothrombosis, due to their complex…”
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Abstract 153: Involvement of Peptidylarginine Deiminase 4 in Eosinophil Extracellular Trap Formation and Contribution to Citrullinated Histone Signal in Thrombi
Published in Arteriosclerosis, thrombosis, and vascular biology (01-05-2023)“…Abstract only Background: Extracellular traps (ETs) formed by neutrophils (NETs) and eosinophils (EETs) have been described in coronary thrombi, contributing…”
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Involvement of peptidylarginine deiminase 4 in eosinophil extracellular trap formation and contribution to citrullinated histone signal in thrombi
Published in Journal of thrombosis and haemostasis (01-06-2024)“…Extracellular traps formed by neutrophils (NETs) and eosinophils (EETs) have been described in coronary thrombi, contributing to thrombus stability. A key…”
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Neutrophils Protect Against Staphylococcus aureus Endocarditis Progression Independent of Extracellular Trap Release
Published in Arteriosclerosis, thrombosis, and vascular biology (01-02-2023)“…Infective endocarditis (IE) is characterized by an infected thrombus at the heart valves. How bacteria bypass the immune system and cause these thrombi remains…”
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Von Willebrand factor and ADAMTS13 impact on the outcome of Staphylococcus aureus sepsis
Published in Journal of thrombosis and haemostasis (01-03-2020)“…Background Previous clinical evidence correlates levels of von Willebrand factor (VWF) and its cleaving protease ADAMTS13 with outcome in septic patients. No…”
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All Staphylococcus aureus bacteraemia-inducing strains can cause infective endocarditis: Results of GWAS and experimental animal studies
Published in The Journal of infection (01-02-2023)“…•Staphylococcus aureus bacteraemia (SAB) can lead to infective endocarditis (IE).•Specific traits of IE-causing strains versus SAB-only are questioned.•GWAS…”
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Ticagrelor prevents infective endocarditis by mitigating Staphylococcus aureus virulence
Published in Archives of cardiovascular diseases supplements (01-06-2022)Get full text
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Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice
Published in JACC. Basic to translational science (01-11-2023)“…In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical…”
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