Search Results - "Meyerovich, Kira"

Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation by Meyerovich, Kira, Ortis, Fernanda, Allagnat, Florent, Cardozo, Alessandra K

“…Insulin-secreting pancreatic β-cells are extremely dependent on their endoplasmic reticulum (ER) to cope with the oscillatory requirement of secreted insulin…”
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Heterozygous inactivation of plasma membrane Ca2+-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability by Pachera, Nathalie, Papin, Julien, Zummo, Francesco P., Rahier, Jacques, Mast, Jan, Meyerovich, Kira, Cardozo, Alessandra K., Herchuelz, André

“…Aims/hypothesis Calcium plays an important role in the process of glucose-induced insulin release in pancreatic beta cells. These cells are equipped with a…”
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The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes by Meyerovich, Kira, Ortis, Fernanda, Cardozo, Alessandra K

“…The prevalence of diabetes has reached 8.8% in worldwide population and is predicted to increase up to 10.4% by 2040. Thus, there is an urgent need for the…”
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Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis by Lambelet, Martine, Terra, Leticia F., Fukaya, Makiko, Meyerovich, Kira, Labriola, Leticia, Cardozo, Alessandra K., Allagnat, Florent

“…Type 1 diabetes (T1D) results from β-cell destruction due to concerted action of both innate and adaptive immune responses. Pro-inflammatory cytokines, such as…”
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The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro by Meyerovich, Kira, Fukaya, Makiko, Terra, Leticia F., Ortis, Fernanda, Eizirik, Decio L., Cardozo, Alessandra K.

“…Aims/hypothesis Activation of the transcription factor nuclear factor (NF)-κB by proinflammatory cytokines plays an important role in beta cell demise in type…”
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SKAP2 , a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients by Fløyel, Tina, Meyerovich, Kira, Prause, Michala C, Kaur, Simranjeet, Frørup, Caroline, Mortensen, Henrik B, Nielsen, Lotte B, Pociot, Flemming, Cardozo, Alessandra K, Størling, Joachim

“…The single nucleotide polymorphism rs7804356 located in the Src kinase-associated phosphoprotein 2 ( ) gene is associated with type 1 diabetes (T1D),…”
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MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells by Meyerovich, Kira, Violato, Natalia M, Fukaya, Makiko, Dirix, Violette, Pachera, Nathalie, Marselli, Lorella, Marchetti, Piero, Strasser, Andreas, Eizirik, Decio L, Cardozo, Alessandra K

“…Induction of endoplasmic reticulum stress and activation of the intrinsic apoptotic pathway is widely believed to contribute to β-cell death in type 1 diabetes…”
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The non-canonical NF-[kappa]B pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro by Meyerovich, Kira, Fukaya, Makiko, Terra, Leticia F, Ortis, Fernanda, Eizirik, Decio L, Cardozo, Alessandra K

“…Aims/hypothesis Activation of the transcription factor nuclear factor (NF)-[kappa]B by proinflammatory cytokines plays an important role in beta cell demise in…”
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Heterozygous inactivation of plasma membrane Ca(2+)-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability by Pachera, Nathalie, Papin, Julien, Zummo, Francesco P, Rahier, Jacques, Mast, Jan, Meyerovich, Kira, Cardozo, Alessandra K, Herchuelz, André

“…Calcium plays an important role in the process of glucose-induced insulin release in pancreatic beta cells. These cells are equipped with a double system…”
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MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic ß-Cells by Meyerovich, Kira, Violato, Natalia M, Fukaya, Makiko, Dirix, Violette, Pachera, Nathalie, Marselli, Lorella, Marchetti, Piero, Strasser, Andreas, Eizirik, Decio L, Cardozo, Alessandra K

“…Induction of endoplasmic reticulum stress and activation of the intrinsic apoptotic pathway is widely believed to contribute to β-cell death in type 1 diabetes…”
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A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes by Fukaya, Makiko, Brorsson, Caroline A, Meyerovich, Kira, Catrysse, Leen, Delaroche, Diane, Vanzela, Emerielle C, Ortis, Fernanda, Beyaert, Rudi, Nielsen, Lotte B, Andersen, Marie L, Mortensen, Henrik B, Pociot, Flemming, van Loo, Geert, Størling, Joachim, Cardozo, Alessandra K

“…Activation of the transcription factor nuclear factor kappa B (NFkB) contributes to β-cell death in type 1 diabetes (T1D). Genome-wide association studies have…”
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Heterozygous inactivation of plasma membrane Ca^sup 2+^-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability by Pachera, Nathalie, Papin, Julien, Zummo, Francesco P, Rahier, Jacques, Mast, Jan, Meyerovich, Kira, Cardozo, Alessandra K, Herchuelz, André

“…Aims/hypothesis Calcium plays an important role in the process of glucose-induced insulin release in pancreatic beta cells. These cells are equipped with a…”
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A20 Inhibits [beta]-Cell Apoptosis by Multiple Mechanisms and Predicts Residual [beta]-Cell Function in Type 1 Diabetes by Fukaya, Makiko, Brorsson, Caroline A, Meyerovich, Kira, Catrysse, Leen, Delaroche, Diane, Vanzela, Emerielle C, Ortis, Fernanda, Beyaert, Rudi, Nielsen, Lotte B, Andersen, Marie L, Mortensen, Henrik B, Pociot, Flemming, van Loo, Geert, Storling, Joachim, Cardozo, Alessandra K

“…Activation of the transcription factor nuclear factor kappa B (NFkB) contributes to [beta]-cell death in type 1 diabetes (T1D). Genome-wide association studies…”
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