Search Results - "Meyer J. Friedman"

Enhancer Activation Requires trans-Recruitment of a Mega Transcription Factor Complex by Liu, Zhijie, Merkurjev, Daria, Yang, Feng, Li, Wenbo, Oh, Soohwan, Friedman, Meyer J., Song, Xiaoyuan, Zhang, Feng, Ma, Qi, Ohgi, Kenneth A., Krones, Anna, Rosenfeld, Michael G.

“…Enhancers provide critical information directing cell-type-specific transcriptional programs, regulated by binding of signal-dependent transcription factors…”
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Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly by Nair, Sreejith J., Yang, Lu, Meluzzi, Dario, Oh, Soohwan, Yang, Feng, Friedman, Meyer J., Wang, Susan, Suter, Tom, Alshareedah, Ibraheem, Gamliel, Amir, Ma, Qi, Zhang, Jie, Hu, Yiren, Tan, Yuliang, Ohgi, Kenneth A., Jayani, Ranveer Singh, Banerjee, Priya R., Aggarwal, Aneel K., Rosenfeld, Michael G.

“…A crucial feature of differentiated cells is the rapid activation of enhancer-driven transcriptional programs in response to signals. The potential…”
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Enhancer–promoter specificity in gene transcription: molecular mechanisms and disease associations by Friedman, Meyer J., Wagner, Tobias, Lee, Haram, Rosenfeld, Michael G., Oh, Soohwan

“…Although often located at a distance from their target gene promoters, enhancers are the primary genomic determinants of temporal and spatial transcriptional…”
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Dynamics of Viral and Host 3D Genome Structure upon Infection by Meyer J. Friedman, Haram Lee, Young-chan Kwon, Soohwan Oh

“…Eukaryotic chromatin is highly organized in the 3D nuclear space and dynamically regulated in response to environmental stimuli. This genomic organization is…”
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Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages by Friedman, Meyer J, Lee, Haram, Lee, June-Yong, Oh, Soohwan

“…Th cell lineage determination and functional specialization are tightly linked to the activation of lineage-determining transcription factors (TFs) that bind…”
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Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration by Li, Shihua, Li, Xiao-Jiang, Friedman, Meyer J, Shah, Anjali G, Fang, Zhi-Hui, Ward, Elizabeth G, Warren, Stephen T

“…Expansion of the polyglutamine (polyQ) tract in human TATA-box binding protein (TBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). It…”
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Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages by Meyer J. Friedman, Haram Lee, June-Yong Lee, Soohwan Oh

“…Th cell lineage determination and functional specialization are tightly linked to the activation of lineage-determining transcription factors (TFs) that bind…”
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Activation of Gene Transcription by Heat Shock Protein 27 May Contribute to Its Neuronal Protection by Friedman, Meyer J., Li, Shihua, Li, Xiao-Jiang

“…Heat shock proteins are up-regulated as a physiological response to stressful stimuli and generally function as molecular chaperones for improperly folded…”
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Polyglutamine Expansion Reduces the Association of TATA-binding Protein with DNA and Induces DNA Binding-independent Neurotoxicity by Friedman, Meyer J., Wang, Chuan-En, Li, Xiao-Jiang, Li, Shihua

“…TATA-binding protein (TBP) is essential for eukaryotic gene transcription. Human TBP contains a polymorphic polyglutamine (polyQ) domain in its N terminus and…”
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Dynamics of Viral and Host 3D Genome Structure upon Infection by Friedman, Meyer J, Lee, Haram, Kwon, Young-Chan, Oh, Soohwan

“…Eukaryotic chromatin is highly organized in the 3D nuclear space and dynamically regulated in response to environmental stimuli. This genomic organization is…”
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Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17 by Shah, Anjali G., Friedman, Meyer J., Huang, Shanshan, Roberts, Meredith, Li, Xiao-Jiang, Li, Shihua

“…TATA binding protein (TBP), a universal transcription factor, is broadly required by nuclear RNA polymerases for the initiation of transcription. TBP contains…”
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Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages by Meyer J. Friedman, Haram Lee, June-Yong Lee, Soohwan Oh

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Polyglutamine Expansion Reduces the Association of TATA-binding Protein with DNA and Induces DNA Binding-independent NeurotoxicityS by Friedman, Meyer J., Wang, Chuan-En, Li, Xiao-Jiang, Li, Shihua

“…TATA-binding protein (TBP) is essential for eukaryotic gene transcription. Human TBP contains a polymorphic polyglutamine (polyQ) domain in its N terminus and…”
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Polyglutamine domain modulates multiple TBP interactions: Implications for its normal function and role in neurodegeneration by Friedman, Meyer J

“…TATA-binding protein (TBP) is prominently involved in eukaryotic transcription initiation by the three major RNA polymerases in the nucleus. While the highly…”
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