Search Results - "Meyer, Sara E"

Single-cell mutation analysis of clonal evolution in myeloid malignancies by Miles, Linde A., Bowman, Robert L., Merlinsky, Tiffany R., Csete, Isabelle S., Ooi, Aik T., Durruthy-Durruthy, Robert, Bowman, Michael, Famulare, Christopher, Patel, Minal A., Mendez, Pedro, Ainali, Chrysanthi, Demaree, Benjamin, Delley, Cyrille L., Abate, Adam R., Manivannan, Manimozhi, Sahu, Sombeet, Goldberg, Aaron D., Bolton, Kelly L., Zehir, Ahmet, Rampal, Raajit, Carroll, Martin P., Meyer, Sara E., Viny, Aaron D., Levine, Ross L.

“…Myeloid malignancies, including acute myeloid leukaemia (AML), arise from the expansion of haematopoietic stem and progenitor cells that acquire somatic…”
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KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs by Yan, Fangxue, Li, Jinyang, Milosevic, Jelena, Petroni, Ricardo, Liu, Suying, Shi, Zhennan, Yuan, Salina, Reynaga, Janice M, Qi, Yuwei, Rico, Joshua, Yu, Sixiang, Liu, Yiman, Rokudai, Susumu, Palmisiano, Neil, Meyer, Sara E, Sung, Pamela J, Wan, Liling, Lan, Fei, Garcia, Benjamin A, Stanger, Ben Z, Sykes, David B, Blanco, M Andrés

“…Epigenetic programs are dysregulated in acute myeloid leukemia (AML) and help enforce an oncogenic state of differentiation arrest. To identify key epigenetic…”
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Context is key for FLT3-ITD by Meyer, Sara E.

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MicroRNA immunomodulating therapeutics by Meyer, Sara E.

“…In this issue of Blood , Su et al 1 employ an elegant microRNA (miRNA or miR) conjugation strategy to unleash the potential of targeted miRNA therapeutics,…”
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The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice by Khandanpour, Cyrus, Krongold, Joseph, Schɒtte, Judith, Bouwman, Frederique, Vassen, Lothar, Gaudreau, Marie-Claude, Chen, Riyan, Calero-Nieto, Fernando J., Diamanti, Evangelia, Hannah, Rebecca, Meyer, Sara E., Grimes, H. Leighton, van der Reijden, Bert A., Jansen, Joop H., Patel, Chandrashekhar V., Peeters, Justine K., Löwenberg, Bob, Dɒhrsen, Ulrich, Göttgens, Bertie, Möröy, Tarik

“…The coding single nucleotide polymorphism GFI136N in the human gene growth factor independence 1 (GFI1) is present in 37-77 of whites and increases the risk…”
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From EMT to HSC to AML: ZEB2 is a cell fate switch by Meyer, Sara E.

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Splicing together the origins of MDS-RS by Meyer, Sara E.

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Genetic heterogeneity and clonal evolution in acute myeloid leukemia by Romer-Seibert, Jennifer S., Meyer, Sara E.

“…PURPOSE OF REVIEWClonal heterogeneity is a significant obstacle to successful treatment of patients with acute myeloid leukemia (AML). Here, we review new…”
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miR-196b-TLR7/8 Signaling Axis Regulates Innate Immune Signaling and Myeloid Maturation in DNMT3A-Mutant AML by Gamlen, Holly A, Romer-Seibert, Jennifer S, Lawler, Michael E, Versace, Amanda M, Goetz, Melanie L, Feng, Yang, Guryanova, Olga A, Palmisiano, Neil, Meyer, Sara E

“…DNMT3A mutations confer a poor prognosis in acute myeloid leukemia (AML), but the molecular mechanisms downstream of DNMT3A mutations in disease pathogenesis…”
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FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia by Sung, Pamela J., Selvam, Murugan, Riedel, Simone S., Xie, Hongbo M., Bryant, Katie, Manning, Bryan, Wertheim, Gerald B., Kulej, Katarzyna, Pham, Lucie, Bowman, Robert L., Peresie, Jennifer, Nemeth, Michael J., Levine, Ross L., Garcia, Benjamin A., Meyer, Sara E., Sidoli, Simone, Bernt, Kathrin M., Carroll, Martin

“…Internal tandem duplication mutations in fms-like tyrosine kinase 3 ( FLT3-ITD ) are recurrent in acute myeloid leukemia (AML) and increase the risk of…”
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DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia by Meyer, Sara E, Qin, Tingting, Muench, David E, Masuda, Kohei, Venkatasubramanian, Meenakshi, Orr, Emily, Suarez, Lauren, Gore, Steven D, Delwel, Ruud, Paietta, Elisabeth, Tallman, Martin S, Fernandez, Hugo, Melnick, Ari, Le Beau, Michelle M, Kogan, Scott, Salomonis, Nathan, Figueroa, Maria E, Grimes, H Leighton

“…Cytogenetically normal acute myeloid leukemia (CN-AML) represents nearly 50% of human AML. Co-occurring mutations in the de novo DNA methyltransferase DNMT3A…”
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A 2-way miRror of red blood cells and leukemia by Grimes, H. Leighton, Meyer, Sara E.

“…In this issue of Blood, the articles by Shaham et al and Wang et al are the first to identify microRNA 486 (miR-486) as a requisite oncomiR and credible…”
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miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential by Meyer, Sara E, Muench, David E, Rogers, Andrew M, Newkold, Tess J, Orr, Emily, O'Brien, Eric, Perentesis, John P, Doench, John G, Lal, Ashish, Morris, Patrick J, Thomas, Craig J, Lieberman, Judy, McGlinn, Edwina, Aronow, Bruce J, Salomonis, Nathan, Grimes, H Leighton

“…We have shown that antagomiR inhibition of miRNA miR-21 and miR-196b activity is sufficient to ablate MLL-AF9 leukemia stem cells (LSC) in vivo. Here, we used…”
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Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts by Raines, Anna M, Adam, Mike, Magella, Bliss, Meyer, Sara E, Grimes, H Leighton, Dey, Sudhansu K, Potter, S Steven

“…Hox genes are key regulators of development. In mammals, the study of these genes is greatly confounded by their large number, overlapping functions and…”
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515 microRNA-375-KLF5 Regulation of Intestinal Epithelial CFTR Function by Wu, David, Meyer, Sara E, Waggoner, Lisa, Vanoni, Simone, Lu, Thomas, Steinbrecher, Kris A, Rothenberg, Marc E, Shroyer, Noah F, Hogan, Simon P

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The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis by Meyer, Sara E., Zinser, Glendon M., Stuart, William D., Pathrose, Peterson, Waltz, Susan E.

“…The Ron receptor tyrosine kinase is expressed in normal breast tissue and is overexpressed in approximately 50% of human breast cancers. Despite the recent…”
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MicroRNAs in the midst of myeloid signal transduction by Stoffers, Sara L., Meyer, Sara E., Grimes, H. Leighton

“…MicroRNA (miRNA) play important roles in the development and physiological function of hematopoietic stem/progenitor and mature cell lineages. In addition,…”
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The Ron receptor tyrosine kinase is not required for adenoma formation in Apc(Min/+) mice by Meyer, Sara E, Waltz, Susan E, Goss, Kathleen H

“…The Ron receptor tyrosine kinase is overexpressed in approximately half of all human colon cancers. Increased Ron expression positively correlates with tumor…”
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Chk21100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice by Meyer, Sara E., Peace, Belinda E., Bahassi, El Mustapha, Kavanaugh, Gina M., Wagh, Purnima K., Robbins, Susan B., Yin, Moying, Wells, Susanne I., Zinser, Glendon M., Stambrook, Peter J., Waltz, Susan E.

“…The CHEK2 (Chk2 in mice) polymorphic variant, CHEK2*1100delC, leads to genomic instability and is associated with an increased risk for breast cancer. The Ron…”
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Krüppel-Like Factor 5 Is Not Required for K-RasG12D Lung Tumorigenesis, but Represses ABCG2 Expression and Is Associated with Better Disease-Specific Survival by Meyer, Sara E, Hasenstein, Jason R, Baktula, Avinash, Velu, Chinavenmani S, Xu, Yan, Wan, Huajing, Whitsett, Jeffrey A, Gilks, C. Blake, Grimes, H. Leighton

“…K-RAS mutations are found in approximately 30% of lung cancers. The transcription factor Krüppel-like Factor 5 (KLF5) has been shown to mediate cellular…”
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