Search Results - "Meyer, RB Jr"

Facile preparation of nuclease resistant 3′ modified oligodeoxynucleotides by Gamper, Howard B., Reed, Michael W., Cox, Thomas, Virosco, Jeanne S., Adams, A. David, Gall, Alexander A., Scholler, John K., Meyer, Rich B.

“…An efficient chemical procedure for the immobilization of carboxylate containing conjugate groups onto controlled pore glass (CPG) is described. The…”
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Exceptional and selective stabilization of A-T rich DNA-DNA duplexes by N-methylpyrrole carboxamide peptides conjugated to oligodeoxynucleotides by Sinyakov, AN, Lokhov, S G, Kutyavin, I V, Gamper, H B, Meyer, RB Jr

“…We now report that covalent attachment of a class of minor groove binding agents, the N-methylpyrrolecarboxamide (MPC) peptides, to short thymidylate or…”
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Oligonucleotides Containing 2-Aminoadenine and 2-Thiothymine Act as Selectively Binding Complementary Agents by Kutyavin, Igor V, Rhinehart, Rebecca L, Lukhtanov, Eugeny A, Gorn, Vladimir V, Meyer, Rich B, Gamper, Howard B

“…A pair of complementary oligodeoxynucleotides (ODNs) uniformly substituted with 2-aminoadenine (A‘) in place of adenine and 2-thiothymine (T‘) in place of…”
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Solution structure of a highly stable DNA duplex conjugated to a minor groove binder by Kumar, Surat, Foti, Matthew, West, John, Schweitzer, Barry I., Reed, Michael W., Gamper, Howard B., Gorn, Vladimir V., Lukhtanov, Eugeny A., Meyer, Rich B.

“…The tripeptide 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI3) binds to the minor groove of DNA with high affinity. When this minor groove binder…”
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Rapid and Efficient Hybridization-Triggered Crosslinking Within a DNA Duplex by an Oligodeoxyribonucleotide Bearing a Conjugated Cyclopropapyrroloindole by Lukhtanov, Eugeny A., Podyminogin, Mikhail A., Kutyavin, Igor V., Meyer, Rich B., Gamper, Howard B.

“…The antitumor antibiotic CC-1065 binds in the minor groove of double-stranded DNA, and the cyclopropapyrroloindole (CPI) subunit of the drug alkylates adjacent…”
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RecA-Catalyzed, Sequence-Specific Alkylation of DNA by Cross-Linking Oligonucleotides. Effects of Length and Nonhomologous Base Substitutions by Podyminogin, Mikhail A, Meyer, Rich B, Gamper, Howard B

“…Oligodeoxyribonucleotides (ODNs) bearing the reactive nitrogen mustard chlorambucil have been used as sequence-directed affinity labeling reagents to…”
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Efficient, specific interstrand cross-linking of double-stranded DNA by a chlorambucil-modified, triplex-forming oligonucleotide by Kutyavin, Igor V, Gamper, Howard B, Gall, Alexander A, Meyer, Rich B

“…We report here that triple-helix-forming ODNs modified at the 3'- and 5'-ends with the clinically used nitrogen mustard chlorambucil are able to rapidly…”
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Structure-Activity Relationships of Cytotoxic Cholesterol-Modified DNA Duplexes by Reed, Michael W, Lukhtanov, Eugeny, Gorn, Vladimir, Lucas, Deborah D, Zhou, James H, Pai, S. Balakrishna, Cheng, Yung-chi, Meyer, Rich B

“…Short DNA duplexes with cholesterol linked at the 3'-terminus of each strand have unique, selective cytotoxic properties. The structural requirements for…”
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Factors influencing the extent and regiospecificity of cross-link formation between single-stranded DNA and reactive complementary oligodeoxynucleotides by Tabone, John C, Stamm, Michael R, Gamper, Howard B, Meyer, Rich B

“…Cross-link formation, within the duplex, by oligodeoxynucleotides containing a 5-[omega-(omega-haloacylamido)alkyl]-2'-deoxyuridine to a complementary…”
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Efficient, specific cross-linking and cleavage of DNA by stable, synthetic complementary oligodeoxynucleotides by MEYER, R. B, TABONE, J. C, HURST, G. D, SMITH, T. M, GAMPER, H

“…"Antisense" oligodeoxynucleotides (ODNs) have generated significant recent interest as potential chemotherapeutic agents. Despite theoretical appeal, the…”
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Discovery of short, 3'-cholesterol-modified DNA duplexes with unique antitumor cell activity by ZHOU, J. H, PAI, B. S, REED, M. W, GAMPER, H. B, LUKHTANOV, E, PODYMINOGIN, M, MEYER, R. B, YUNG-CHI CHENG

“…A new class of modified oligodeoxynucleotides with unique, selective cytotoxic properties has been discovered. Self-complementary, 3'-cholesterol-modified…”
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Nucleoside of 1,4-thiazin-3-one and derivatives as tetrahedral intermediate analogues of enzymes in pyrimidine nucleoside metabolism by Marcus, TE, Gundy, A, Levenson, CH, Meyer, RB Jr

“…Reaction of the trimethylsilylated derivative of 1,4-thiazin-3-one with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose in the presence of SnCl sub(4) gave,…”
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Nucleosides of 1,4-thiazin-3-one and derivatives as tetrahedral intermediate analogs of enzymes in pyrimidine nucleoside metabolism by Marcus, E. Ted, Gundy, Afaf, Levenson, Corey H, Meyer, Rich B

“…Reaction of the trimethylsilylated derivative of 1,4-thiazin-3-one with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose in the presence of SnCl4 gave, after…”
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Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids by Wong, Corinne G, Meyer, Rich B

“…A series of 2-substituted inosine monophosphate (IMP) and inosine derivatives were synthesized and tested for inhibitory activity against IMP dehydrogenase…”
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Inhibition of inosinic acid dehydrogenase by 8-substituted purine nucleotides by Skibo, Edward B, Meyer, Rich B

“…A series of 8-substituted derivatives of adenosine monophosphate (AMP) and inosine monophosphate (IMP) were synthesized and examined for their ability to…”
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