Search Results - "Meyer, Jill A."

Characterization of 11C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation by Territo, Paul R, Meyer, Jill A, Peters, Jonathan S, Riley, Amanda A, McCarthy, Brian P, Gao, Mingzhang, Wang, Min, Green, Mark A, Zheng, Qi-Huang, Hutchins, Gary D

“…The purinergic receptor subtype 7 (P2X7R) represents a novel molecular target for imaging neuroinflammation via PET. GSK1482160, a potent P2X7R antagonist, has…”
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Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor by Wang, Min, Gao, Mingzhang, Meyer, Jill A., Peters, Jonathan S., Zarrinmayeh, Hamideh, Territo, Paul R., Hutchins, Gary D., Zheng, Qi-Huang

“…[Display omitted] P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases…”
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Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice by Oblak, Adrian L., Kotredes, Kevin P., Pandey, Ravi S., Reagan, Alaina M., Ingraham, Cynthia, Perkins, Bridget, Lloyd, Christopher, Baker, Deborah, Lin, Peter B., Soni, Disha M., Tsai, Andy P., Persohn, Scott A., Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Meyer, Jill A., Peters, Johnathan S., Figueiredo, Lucas L., Sasner, Michael, Territo, Paul R., Sukoff Rizzo, Stacey J., Carter, Gregory W., Lamb, Bruce T., Howell, Gareth R.

“…Obesity is recognized as a significant risk factor for Alzheimer’s disease (AD). Studies have supported the notion that obesity accelerates AD-related…”
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Prophylactic evaluation of verubecestat on disease‐ and symptom‐modifying effects in 5XFAD mice by Oblak, Adrian L., Cope, Zackary A., Quinney, Sara K., Pandey, Ravi S., Biesdorf, Carla, Masters, Andi R., Onos, Kristen D., Haynes, Leslie, Keezer, Kelly J., Meyer, Jill A., Peters, Jonathan S., Persohn, Scott A., Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Little, Gabriela, Williams, Sean‐Paul, Noarbe, Brenda, Obenaus, Andre, Sasner, Michael, Howell, Gareth R., Carter, Gregory W., Williams, Harriet, Lamb, Bruce T., Territo, Paul R., Sukoff Rizzo, Stacey J.

“…Introduction Alzheimer's disease (AD) is the most common form of dementia. Beta‐secretase (BACE) inhibitors have been proposed as potential therapeutic…”
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Synthesis and in vitro biological evaluation of new P2X7R radioligands [11C]halo-GSK1482160 analogs by Gao, Mingzhang, Wang, Min, Meyer, Jill A., Territo, Paul R., Hutchins, Gary D., Zarrinmayeh, Hamideh, Zheng, Qi-Huang

“…[Display omitted] The reference standards halo-GSK1482160 (F-, Br-, and I-) and their corresponding precursors desmethyl-halo-GSK1482160 (F-, Br-, and I-) were…”
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Synthesis and preliminary biological evaluation of a novel P2X7R radioligand [18F]IUR-1601 by Gao, Mingzhang, Wang, Min, Glick-Wilson, Barbara E., Meyer, Jill A., Peters, Jonathan S., Territo, Paul R., Green, Mark A., Hutchins, Gary D., Zarrinmayeh, Hamideh, Zheng, Qi-Huang

“…[Display omitted] The reference standard IUR-1601 ((S)-N-(2-chloro-3-(trifluoromethyl)benzyl)-1-(2-fluoroethyl)-5-oxopyrrolidine-2-carboxamide) was synthesized…”
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Synthesis and preliminary biological evaluation of [11C]methyl (2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-yl)-d-leucinate for the fractalkine receptor (CX3CR1) by Gao, Mingzhang, Wang, Min, Meyer, Jill A., Peters, Jonathan S., Zarrinmayeh, Hamideh, Territo, Paul R., Hutchins, Gary D., Zheng, Qi-Huang

“…[Display omitted] The reference standard methyl (2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-yl)-d-leucinate (5) and its precursor…”
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Pharmacodynamics Assessment of Aducanumab in 5XFAD mice: A MODEL‐AD PTC Study by Territo, Paul R, Quinney, Sara K, Masters, Andrea R, Haynes, Katy A, Cope, Zackery A, Little, Gabriela, Williams, Sean‐Paul, Meyer, Jill A, Peters, Jonathan, Figueiredo, Lucas, Persohn, Scott C, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Seyfried, Nicholas T., Onos, Kristen D, Sasner, Michael, Howell, Gareth R, Carter, Gregory W, Oblak, Adrian L, Lamb, Bruce T, Rizzo, Stacey J Sukoff

“…Background The Preclinical Testing Core (PTC) of the Model Organism Development for Evaluation of Late Onset Alzheimer’s Disease (MODEL‐AD) consortium…”
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Synthesis and initial in vitro characterization of a new P2X7R radioligand [18F]IUR-1602 by Gao, Mingzhang, Wang, Min, Glick-Wilson, Barbara E., Meyer, Jill A., Peters, Jonathan S., Territo, Paul R., Green, Mark A., Hutchins, Gary D., Zarrinmayeh, Hamideh, Zheng, Qi-Huang

“…The overexpression of P2X7R is associated with neuroinflammation and plays an important role in various neurodegenerative diseases. The [18F]fluoropropyl…”
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Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation by Territo, Paul R, Meyer, Jill A, Peters, Jonathan S, Riley, Amanda A, McCarthy, Brian P, Gao, Mingzhang, Wang, Min, Green, Mark A, Zheng, Qi-Huang, Hutchins, Gary D

“…The purinergic receptor subtype 7 (P2X7R) represents a novel molecular target for imaging neuroinflammation via PET. GSK1482160, a potent P2X7R antagonist, has…”
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Characterization of ^sup 11^C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation by Territo, Paul R, Meyer, Jill A, Peters, Jonathan S, Riley, Amanda A, McCarthy, Brian P, Gao, Mingzhang, Wang, Min, Green, Mark A, Zheng, Qi-Huang, Hutchins, Gary D

“…The purinergic receptor subtype 7 (P2X7R) represents a novel molecular target for imaging neuroinflammation via PET. GSK1482160, a potent P2X7R antagonist, has…”
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Pharmacokinetic, pharmacodynamic and transcriptomic analyses of verubecestat treatment in 5XFAD mice: Development of new models and analysis methods/novel assays and technologies by Territo, Paul R., Quinney, Sara K., Biesdorf, Carla, Masters, Andrea R., Onos, Kristen, Haynes, Leslie, Keezer, Kelly, Cope, Zackery A., Meyer, Jill A., Peters, Jonathan, Persohn, Scott C., Figueiredo, Lucas, Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Sasner, Michael, Howell, Gareth, Carter, Gregory W., Oblak, Adrian L., Lamb, Bruce T., Rizzo, Stacey J. Sukoff

“…Abstract Background The Preclinical Testing Core (PTC) of the Model Organism Development for Late Onset Alzheimer’s Disease (MODEL‐AD) consortium established a…”
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Pharmacokinetic, pharmacodynamic and transcriptomic analyses of verubecestat treatment in 5XFAD mice by Territo, Paul R., Quinney, Sara K., Biesdorf, Carla, Masters, Andrea R., Onos, Kristen, Haynes, Leslie, Keezer, Kelly, Cope, Zackery A., Meyer, Jill A., Peters, Jonathan, Persohn, Scott C., Figueiredo, Lucas, Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Sasner, Michael, Howell, Gareth, Carter, Gregory W., Oblak, Adrian L., Lamb, Bruce T., Rizzo, Stacey J. Sukoff

“…Background The Preclinical Testing Core (PTC) of the Model Organism Development for Late Onset Alzheimer’s Disease (MODEL‐AD) consortium established a…”
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Plcg2 M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice by Oblak, Adrian L, Kotredes, Kevin P, Pandey, Ravi S, Reagan, Alaina M, Ingraham, Cynthia, Perkins, Bridget, Lloyd, Christopher, Baker, Deborah, Lin, Peter B, Soni, Disha M, Tsai, Andy P, Persohn, Scott A, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Meyer, Jill A, Peters, Johnathan S, Figueiredo, Lucas L, Sasner, Michael, Territo, Paul R, Sukoff Rizzo, Stacey J, Carter, Gregory W, Lamb, Bruce T, Howell, Gareth R

“…Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have supported the notion that obesity accelerates AD-related…”
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CRITICAL EVALUATION OF THE PHARMACOKINETICS OF VERUBECESTAT IN AGED 5XFAD MICE by Territo, Paul R., Quinney, Sara K., Biesdorf, Carla, Onos, Kristen, Haynes, Leslie, Keezer, Kelly J., Meyer, Jill A., Peters, Jonathan, Persohn, Scott C., Bedwell, Amanda, Eldridge, Kierra, Speedy, Rachael, Sasner, Michael, Howell, Gareth, Williams, Harriet M., Oblak, Adrian L., Lamb, Bruce T., Sukoff Rizzo, Stacey J.

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P4‐079: CRITICAL EVALUATION OF THE PHARMACOKINETICS OF VERUBECESTAT IN AGED 5XFAD MICE by Territo, Paul R., Quinney, Sara K., Biesdorf, Carla, Onos, Kristen, Haynes, Leslie, Keezer, Kelly J., Meyer, Jill A., Peters, Jonathan, Persohn, Scott C., Bedwell, Amanda, Eldridge, Kierra, Speedy, Rachael, Sasner, Michael, Howell, Gareth, Williams, Harriet M., Oblak, Adrian L., Lamb, Bruce T., Sukoff Rizzo, Stacey J.

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P2‐045: THE MODEL‐AD CONSORTIUM PRECLINICAL TESTING PIPELINE: PHARMACOKINETICS AND PHARMACODYNAMICS OF PROPHYLACTIC TREATMENT WITH LEVETIRACETAM IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE by Sukoff Rizzo, Stacey J., Quinney, Sara K., Onos, Kristen D., Keezer, Kelly J., Jones, David R., Masters, Andrea R., Metzger, Ingrid F., Meyer, Jill A., Peters, Jonathan, Persohn, Scott C., McCarthy, Brian P., Riley, Amanda A., Sasner, Michael, Howell, Gareth R., Williams, Harriett, Oblak, Adrian L., Lamb, Bruce T., Territo, Paul

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THE MODEL-AD CONSORTIUM PRECLINICAL TESTING PIPELINE: PHARMACOKINETICS AND PHARMACODYNAMICS OF PROPHYLACTIC TREATMENT WITH LEVETIRACETAM IN THE 5XFAD MOUSE MODEL OF ALZHEIMER’S DISEASE by Sukoff Rizzo, Stacey J., Quinney, Sara K., Onos, Kristen D., Keezer, Kelly J., Jones, David R., Masters, Andrea R., Metzger, Ingrid F., Meyer, Jill A., Peters, Jonathan, Persohn, Scott C., McCarthy, Brian P., Riley, Amanda A., Sasner, Michael, Howell, Gareth R., Williams, Harriett, Oblak, Adrian L., Lamb, Bruce T., Territo, Paul

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Dick Goehler, 1956-2011: "loyalty, dedication, and a man of his word." by Meyer, Jill A

“…I could share the familiar things about [Dick Goehler] that would put smiles on lots of faces in the room: voice mail messages at 4:30 a.m., featuring Dick's…”
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