Search Results - "Mewis, Ryan"

Application of Parahydrogen Induced Polarization Techniques in NMR Spectroscopy and Imaging by Duckett, Simon B, Mewis, Ryan E

“…Magnetic resonance provides a versatile platform that allows scientists to examine many different types of phenomena. However, the sensitivity of both NMR…”
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Signal amplification by reversible exchange (SABRE) by Mewis, Ryan E.

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Developments and advances concerning the hyperpolarisation technique SABRE by Mewis, Ryan E.

“…To overcome the inherent sensitivity issue in NMR and MRI, hyperpolarisation techniques are used. Signal Amplification By Reversible Exchange (SABRE) is a…”
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The theory and practice of hyperpolarization in magnetic resonance using parahydrogen by Green, Richard A, Adams, Ralph W, Duckett, Simon B, Mewis, Ryan E, Williamson, David C, Green, Gary G R

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Iridium N-Heterocyclic Carbene Complexes as Efficient Catalysts for Magnetization Transfer from para-Hydrogen by Cowley, Michael J, Adams, Ralph W, Atkinson, Kevin D, Cockett, Martin C. R, Duckett, Simon B, Green, Gary G. R, Lohman, Joost A. B, Kerssebaum, Rainer, Kilgour, David, Mewis, Ryan E

“…While the characterization of materials by NMR is hugely important in the physical and biological sciences, it also plays a vital role in medical imaging. This…”
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Rapid SABRE Catalyst Scavenging Using Functionalized Silicas by Robertson, Thomas B R, Clarke, Leon J, Mewis, Ryan E

“…In recent years the NMR hyperpolarisation method signal amplification by reversible exchange (SABRE) has been applied to multiple substrates of potential…”
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Bacterial dominance is due to effective utilisation of secondary metabolites produced by competitors by Morgan, Benjamin G., Warren, Paul, Mewis, Ryan E., Rivett, Damian W.

“…Interactions between bacteria govern the progression of respiratory infections; however, the mechanisms underpinning these interactions are still unclear…”
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Optimization of SABRE for polarization of the tuberculosis drugs pyrazinamide and isoniazid by Zeng, Haifeng, Xu, Jiadi, Gillen, Joseph, McMahon, Michael T., Artemov, Dmitri, Tyburn, Jean-Max, Lohman, Joost A.B., Mewis, Ryan E., Atkinson, Kevin D., Green, Gary G.R., Duckett, Simon B., van Zijl, Peter C.M.

“…[Display omitted] •SABRE polarization of two drugs.•Up to 8% polarization of proton is achieved in less than 1min.•SABRE polarization dependence on…”
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3,4-Methylenedioxymethamphetamine quantification via benchtop 1H qNMR spectroscopy: Method validation and its application to ecstasy tablets collected at music festivals by Sutcliffe, Oliver B., Mewis, Ryan E., Kemsley, E. Kate, Williamson, David C.

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Improving the hyperpolarization of (31)P nuclei by synthetic design by Burns, Michael J, Rayner, Peter J, Green, Gary G R, Highton, Louise A R, Mewis, Ryan E, Duckett, Simon B

“…Traditional (31)P NMR or MRI measurements suffer from low sensitivity relative to (1)H detection and consequently require longer scan times. We show here that…”
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Toward Biocompatible Nuclear Hyperpolarization Using Signal Amplification by Reversible Exchange: Quantitative in Situ Spectroscopy and High-Field Imaging by Hövener, Jan-Bernd, Schwaderlapp, Niels, Borowiak, Robert, Lickert, Thomas, Duckett, Simon B, Mewis, Ryan E, Adams, Ralph W, Burns, Michael J, Highton, Louise A. R, Green, Gary G. R, Olaru, Alexandra, Hennig, Jürgen, von Elverfeldt, Dominik

“…Signal amplification by reversible exchange (SABRE) of a substrate and parahydrogen at a catalytic center promises to overcome the inherent insensitivity of…”
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Hyperpolarisation of Mirfentanil by SABRE in the Presence of Heroin by Robertson, Thomas B. R., Gilbert, Nicolas, Sutcliffe, Oliver B., Mewis, Ryan E.

“…Mirfentanil, a fentanyl derivative that is a μ‐opioid partial agonist, is hyperpolarised via Signal Amplification By Reversible Exchange (SABRE), a…”
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Determination of the pK a Value of a Brønsted Acid by 19 F NMR Spectroscopy by Griffiths, Emily F, Dixon, Jay A, Caffyn, Andrew J M, Langley, Stuart K, Maciá, Beatriz, Caprio, Vittorio, Mewis, Ryan E

“…Brønsted acids, such as phosphoric acids derived from chiral 1,1'-bi-2-naphthol (BINOL), are important catalysts in the formation of carbon-carbon and…”
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Guilty by dissociation: Part B: evaluation of Supercritical Fluid Chromatography (SFC-UV) for the analysis of regioisomeric diphenidine-derived Novel Psychoactive Substances (NPS) by Cochrane, Graeme, Field, Jennifer K., Hulme, Matthew C., Gilbert, Nicolas, Mewis, Ryan E., Euerby, Melvin R., Sutcliffe, Oliver B.

“…Supercritical Fluid Chromatography (SFC-UV) employing a carbon dioxide (CO2) and 10 mM ammonium acetate in MeOH-water (95:5 v/v) gradient provides a rapid…”
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A hyperpolarized equilibrium for magnetic resonance by Hövener, Jan-Bernd, Schwaderlapp, Niels, Lickert, Thomas, Duckett, Simon B., Mewis, Ryan E., Highton, Louise A. R., Kenny, Stephen M., Green, Gary G. R., Leibfritz, Dieter, Korvink, Jan G., Hennig, Jürgen, von Elverfeldt, Dominik

“…Nuclear magnetic resonance spectroscopy and imaging (MRI) play an indispensable role in science and healthcare but use only a tiny fraction of their potential…”
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Iridium(III) Hydrido N‑Heterocyclic Carbene–Phosphine Complexes as Catalysts in Magnetization Transfer Reactions by Fekete, Marianna, Bayfield, Oliver, Duckett, Simon B, Hart, Sam, Mewis, Ryan E, Pridmore, Natalie, Rayner, Peter J, Whitwood, Adrian

“…The hyperpolarization (HP) method signal amplification by reversible exchange (SABRE) uses para-hydrogen to sensitize substrate detection by NMR. The catalyst…”
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Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application by Mewis, Ryan E, Fekete, Marianna, Green, Gary G R, Whitwood, Adrian C, Duckett, Simon B

“…The catalyst which is used in the signal amplification by reversible exchange (SABRE) process facilitates substrate hyperpolarisation while acting to speed up…”
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Strategies for the Hyperpolarization of Acetonitrile and Related Ligands by SABRE by Mewis, Ryan E, Green, Richard A, Cockett, Martin C. R, Cowley, Michael J, Duckett, Simon B, Green, Gary G. R, John, Richard O, Rayner, Peter J, Williamson, David C

“…We report on a strategy for using SABRE (signal amplification by reversible exchange) for polarizing 1H and 13C nuclei of weakly interacting ligands which…”
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Detection, discrimination and quantification of amphetamine, cathinone and nor‐ephedrine regioisomers using benchtop 1H and 19F nuclear magnetic resonance spectroscopy by Hulme, Matthew C., Hayatbakhsh, Armita, Brignall, Rachel M., Gilbert, Nicolas, Costello, Andrew, Schofield, Christopher J., Williamson, David C., Kemsley, E. Kate, Sutcliffe, Oliver B., Mewis, Ryan E.

“…Amphetamine and cathinone derivatives are abused recreationally due to the sense of euphoria they provide to the user. Methodologies for the rapid detection of…”
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Utilization of SABRE-Derived Hyperpolarization To Detect Low-Concentration Analytes via 1D and 2D NMR Methods by Lloyd, Lyrelle S, Adams, Ralph W, Bernstein, Michael, Coombes, Steven, Duckett, Simon B, Green, Gary G. R, Lewis, Richard. J, Mewis, Ryan E, Sleigh, Christopher J

“…The characterization of materials by the inherently insensitive method of NMR spectroscopy plays a vital role in chemistry. Increasingly, hyperpolarization is…”
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