Search Results - "Meuth, Sven G."

Skeletal muscle as potential central link between sarcopenia and immune senescence by Nelke, Christopher, Dziewas, Rainer, Minnerup, Jens, Meuth, Sven G., Ruck, Tobias

“…As our population grows older, age-related pathologies are becoming more prevalent. Deterioration of skeletal muscle and the immune system manifests as…”
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Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis by Schafflick, David, Xu, Chenling A., Hartlehnert, Maike, Cole, Michael, Schulte-Mecklenbeck, Andreas, Lautwein, Tobias, Wolbert, Jolien, Heming, Michael, Meuth, Sven G., Kuhlmann, Tanja, Gross, Catharina C., Wiendl, Heinz, Yosef, Nir, Meyer zu Horste, Gerd

“…Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF…”
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Alemtuzumab in Multiple Sclerosis: Mechanism of Action and Beyond by Ruck, Tobias, Bittner, Stefan, Wiendl, Heinz, Meuth, Sven G

“…Alemtuzumab is a humanized monoclonal antibody against CD52 (cluster of differentiation 52) and is approved for the therapy of relapsing-remitting multiple…”
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The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders-A Systematic Review by Göbel, Kerstin, Eichler, Susann, Wiendl, Heinz, Chavakis, Triantafyllos, Kleinschnitz, Christoph, Meuth, Sven G

“…The interaction of coagulation factors has been shown to go beyond their traditional roles in hemostasis and to affect the development of inflammatory…”
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Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society by Melzer, Nico, Ruck, Tobias, Fuhr, Peter, Gold, Ralf, Hohlfeld, Reinhard, Marx, Alexander, Melms, Arthur, Tackenberg, Björn, Schalke, Berthold, Schneider-Gold, Christiane, Zimprich, Fritz, Meuth, Sven G., Wiendl, Heinz

“…Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular synaptic transmission. The clinical hallmark of MG consists of fluctuating…”
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Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration by Speicher, Anna M, Wiendl, Heinz, Meuth, Sven G, Pawlowski, Matthias

“…Microglia play an essential role for central nervous system (CNS) development and homeostasis and have been implicated in the onset, progression, and clearance…”
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The role of the ZEB1–neuroinflammation axis in CNS disorders by Poonaki, Elham, Kahlert, Ulf Dietrich, Meuth, Sven G, Gorji, Ali

“…Abstract Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–mesenchymal transition (EMT), a process whereby epithelial cells…”
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Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration by Kleinschnitz, Christoph, Grund, Henrike, Wingler, Kirstin, Armitage, Melanie E, Jones, Emma, Mittal, Manish, Barit, David, Schwarz, Tobias, Geis, Christian, Kraft, Peter, Barthel, Konstanze, Schuhmann, Michael K, Herrmann, Alexander M, Meuth, Sven G, Stoll, Guido, Meurer, Sabine, Schrewe, Anja, Becker, Lore, Gailus-Durner, Valérie, Fuchs, Helmut, Klopstock, Thomas, de Angelis, Martin Hrabé, Jandeleit-Dahm, Karin, Shah, Ajay M, Weissmann, Norbert, Schmidt, Harald H H W

“…Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of…”
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NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage by Casas, Ana I., Geuss, Eva, Kleikers, Pamela W. M., Mencl, Stine, Herrmann, Alexander M., Buendia, Izaskun, Egea, Javier, Meuth, Sven G., Lopez, Manuela G., Kleinschnitz, Christoph, Schmidt, Harald H. H. W.

“…Ischemic injury represents the most frequent cause of death and disability, and it remains unclear why, of all body organs, the brain is most sensitive to…”
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The role of iron metabolism in the pathogenesis and treatment of multiple sclerosis by Duarte-Silva, Eduardo, Meuth, Sven G, Peixoto, Christina Alves

“…Multiple sclerosis is a severe demyelinating disease mediated by cells of the innate and adaptive immune system, especially pathogenic T lymphocytes that…”
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CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome by Gross, Catharina C., Meyer, Céline, Bhatia, Urvashi, Yshii, Lidia, Kleffner, Ilka, Bauer, Jan, Tröscher, Anna R., Schulte-Mecklenbeck, Andreas, Herich, Sebastian, Schneider-Hohendorf, Tilman, Plate, Henrike, Kuhlmann, Tanja, Schwaninger, Markus, Brück, Wolfgang, Pawlitzki, Marc, Laplaud, David-Axel, Loussouarn, Delphine, Parratt, John, Barnett, Michael, Buckland, Michael E., Hardy, Todd A., Reddel, Stephen W., Ringelstein, Marius, Dörr, Jan, Wildemann, Brigitte, Kraemer, Markus, Lassmann, Hans, Höftberger, Romana, Beltrán, Eduardo, Dornmair, Klaus, Schwab, Nicholas, Klotz, Luisa, Meuth, Sven G., Martin-Blondel, Guillaume, Wiendl, Heinz, Liblau, Roland

“…Neuroinflammation is often associated with blood-brain-barrier dysfunction, which contributes to neurological tissue damage. Here, we reveal the…”
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Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity by Hucke, Stephanie, Eschborn, Melanie, Liebmann, Marie, Herold, Martin, Freise, Nicole, Engbers, Annika, Ehling, Petra, Meuth, Sven G, Roth, Johannes, Kuhlmann, Tanja, Wiendl, Heinz, Klotz, Luisa

“…Abstract The increasing incidence in Multiple Sclerosis (MS) during the last decades in industrialized countries might be linked to a change in dietary habits…”
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The role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis by Ismail, Fatme Seval, Meuth, Sven G, Melzer, Nico

“…Autoimmune encephalitis (AE) is an inflammatory brain disease which is frequently associated with antibodies (Abs) against cell-surface, synaptic or…”
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Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species by Kovac, Stjepana, Dinkova Kostova, Albena T, Herrmann, Alexander M, Melzer, Nico, Meuth, Sven G, Gorji, Ali

“…Acquired epilepsies can arise as a consequence of brain injury and result in unprovoked seizures that emerge after a latent period of epileptogenesis. These…”
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Infectious mononucleosis is associated with an increased incidence of multiple sclerosis: Results from a cohort study of 32,116 outpatients in Germany by Loosen, Sven H., Doege, Corinna, Meuth, Sven G., Luedde, Tom, Kostev, Karel, Roderburg, Christoph

“…Background The pathogenesis of multiple sclerosis (MS) has not yet been fully uncovered. There is increasing evidence that Epstein-Barr-Virus (EBV) infection,…”
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Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease by Schröder, Jens B, Pawlowski, Matthias, Meyer Zu Hörste, Gerd, Gross, Catharina C, Wiendl, Heinz, Meuth, Sven G, Ruck, Tobias, Warnecke, Tobias

“…Parkinson's disease (PD) is a common neurodegenerative disorder. The contribution of the immune system to its pathogenesis remains incompletely understood. In…”
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Independent risk factors for myasthenic crisis and disease exacerbation in a retrospective cohort of myasthenia gravis patients by Nelke, Christopher, Stascheit, Frauke, Eckert, Carmen, Pawlitzki, Marc, Schroeter, Christina B, Huntemann, Niklas, Mergenthaler, Philipp, Arat, Ercan, Öztürk, Menekse, Foell, Dirk, Schreiber, Stefanie, Vielhaber, Stefan, Gassa, Asmae, Stetefeld, Henning, Schroeter, Michael, Berger, Benjamin, Totzeck, Andreas, Hagenacker, Tim, Meuth, Sven G, Meisel, Andreas, Wiendl, Heinz, Ruck, Tobias

“…Myasthenic crisis (MC) and disease exacerbation in myasthenia gravis (MG) are associated with significant lethality and continue to impose a high disease…”
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Glial Activation Markers in CSF and Serum From Patients With Primary Progressive Multiple Sclerosis: Potential of Serum GFAP as Disease Severity Marker? by Abdelhak, Ahmed, Hottenrott, Tilman, Morenas-Rodríguez, Estrella, Suárez-Calvet, Marc, Zettl, Uwe K, Haass, Christian, Meuth, Sven G, Rauer, Sebastian, Otto, Markus, Tumani, Hayrettin, Huss, André

“…In progressive multiple sclerosis (MS), glial activation is thought to be a relevant mechanism of disability progression. Therefore, assessment of the glial…”
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Astrocyte-mediated inflammation in cortical spreading depression by Ghaemi, Amir, Alizadeh, Leila, Babaei, Shahnaz, Jafarian, Maryam, Khaleghi Ghadiri, Maryam, Meuth, Sven G, Kovac, Stjepana, Gorji, Ali

“…Background Cortical spreading depression (CSD) related diseases such as migraine, cerebrovascular diseases, and epilepsy have been associated with reactive…”
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Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology by Sonner, Jana K., Keil, Melanie, Falk-Paulsen, Maren, Mishra, Neha, Rehman, Ateequr, Kramer, Magdalena, Deumelandt, Katrin, Röwe, Julian, Sanghvi, Khwab, Wolf, Lara, von Landenberg, Anna, Wolff, Hendrik, Bharti, Richa, Oezen, Iris, Lanz, Tobias V., Wanke, Florian, Tang, Yilang, Brandao, Ines, Mohapatra, Soumya R., Epping, Lisa, Grill, Alexandra, Röth, Ralph, Niesler, Beate, Meuth, Sven G., Opitz, Christiane A., Okun, Jürgen G., Reinhardt, Christoph, Kurschus, Florian C., Wick, Wolfgang, Bode, Helge B., Rosenstiel, Philip, Platten, Michael

“…The interaction between the mammalian host and its resident gut microbiota is known to license adaptive immune responses. Nutritional constituents strongly…”
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