Search Results - "Meuth, Mark"

Chk1 suppressed cell death by Meuth, Mark

“…The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression…”
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Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1 by Gagou, Mary E, Zuazua-Villar, Pedro, Meuth, Mark

“…H2AX phosphorylation at serine 139 (gammaH2AX) is a sensitive indicator of both DNA damage and DNA replication stress. Here we show that gammaH2AX formation is…”
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Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress by Rodriguez, Rene, Meuth, Mark

“…Cells respond to DNA replication stress by triggering cell cycle checkpoints, repair, or death. To understand the role of the DNA damage response pathways in…”
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Distinct microRNA alterations characterize high- and low-grade bladder cancer by Catto, James W F, Miah, Saiful, Owen, Helen C, Bryant, Helen, Myers, Katie, Dudziec, Ewa, Larré, Stéphane, Milo, Marta, Rehman, Ishtiaq, Rosario, Derek J, Di Martino, Erica, Knowles, Margaret A, Meuth, Mark, Harris, Adrian L, Hamdy, Freddie C

“…Urothelial carcinoma of the bladder (UCC) is a common disease that arises by at least two different molecular pathways. The biology of UCC is incompletely…”
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Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress by Desmarais, Joelle A, Unger, Christian, Damjanov, Ivan, Meuth, Mark, Andrews, Peter

“…Human induced pluripotent stem (hiPS) cells have the ability to undergo self-renewal and differentiation similarly to human embryonic stem (hES) cells. We have…”
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Promoter Hypermethylation Identifies Progression Risk in Bladder Cancer by YATES, David R, REHMAN, Ishtiaq, ABBOD, Maysam F, MEUTH, Mark, CROSS, Simon S, LINKENS, Derek A, HAMDY, Freddie C, CATTOL, James W. F

“…Purpose: New methods to accurately predict an individual tumor behavior are urgently required to improve the treatment of cancer. We previously found that…”
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Deficient DNA Damage Response and Cell Cycle Checkpoints Lead to Accumulation of Point Mutations in Human Embryonic Stem Cells by Hyka-Nouspikel, Nevila, Desmarais, Joëlle, Gokhale, Paul J., Jones, Mark, Meuth, Mark, Andrews, Peter W., Nouspikel, Thierry

“…Human embryonic stem cells (hESCs) tend to lose genomic integrity during long periods of culture in vitro and to acquire a cancer‐like phenotype. In this…”
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Promoter Hypermethylation Is Associated With Tumor Location, Stage, and Subsequent Progression in Transitional Cell Carcinoma by CATTO, James W. F, AZZOUZI, Abdel-Rahmene, HAMDY, Freddie C, REHMAN, Ishtiaq, FEELEY, Kenneth M, CROSS, Simon S, AMIRA, Najla, FROMONT, Gaelle, SIBONY, Mathilde, CUSSENOT, Oliver, MEUTH, Mark

“…Transitional cell carcinoma (TCC) is a pan-urothelial disease characterized by multiplicity. Although little is known about the molecular events in upper-tract…”
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Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress by Gagou, Mary E, Ganesh, Anil, Phear, Geraldine, Robinson, Darren, Petermann, Eva, Cox, Angela, Meuth, Mark

“…Unwinding duplex DNA is a critical processing step during replication, repair and transcription. Pif1 are highly conserved non-processive 5'->3' DNA helicases…”
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Suppression of Apoptosis by PIF1 Helicase in Human Tumor Cells by GAGOU, Mary E, GANESH, Anil, THOMPSON, Ruth, PHEAR, Geraldine, SANDERS, Cyril, MEUTH, Mark

“…Defining the processes that sustain telomere maintenance is critical to our understanding of cancer and longevity. PIF1 is a nonprocessive 5'->3' human DNA…”
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Molecular Detection of Localized Prostate Cancer Using Quantitative Methylation-Specific PCR on Urinary Cells Obtained Following Prostate Massage by ROUPRET, Morgan, HUPERTAN, Vincent, ROZET, Francois, CATHELINEAU, Xavier, VALLANCIEN, Guy, HAMDY, Freddie C, CUSSENOT, Olivier, YATES, David R, CATTO, James W. F, REHMAN, Ishtiaq, MOUTH, Mark, RICCI, Sylvie, LACAVE, Roger, CANCEL-TASSIN, Géraldine, DE LA TAILLE, Alexandre

“…Purpose: The diagnosis of localized prostate cancer is difficult due to a lack of cancer-specific biomarkers. Many patients require repeat prostate biopsies to…”
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Different Roles for Nonhomologous End Joining and Homologous Recombination following Replication Arrest in Mammalian Cells by Lundin, Cecilia, Erixon, Klaus, Arnaudeau, Catherine, Schultz, Niklas, Jenssen, Dag, Meuth, Mark, Helleday, Thomas

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Thymidine Selectively Enhances Growth Suppressive Effects of Camptothecin/Irinotecan in MSI+ Cells and Tumors Containing a Mutation of MRE11 by Rodriguez, Rene, Hansen, Lasse Tengbjerg, Phear, Geraldine, Scorah, Jennifer, Spang-Thomsen, Mogens, Cox, Angela, Helleday, Thomas, Meuth, Mark

“…Purpose: DNA synthesis inhibitors and damaging agents are widely used in cancer therapy; however, sensitivity of tumors to such agents is highly variable. The…”
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ATM is required for the cellular response to thymidine induced replication fork stress by Bolderson, Emma, Scorah, Jennifer, Helleday, Thomas, Smythe, Carl, Meuth, Mark

“…Genetically distinct checkpoints, activated as a consequence of either DNA replication arrest or ionizing radiation-induced DNA damage, integrate DNA repair…”
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ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress by Myers, Katie, Gagou, Mary E, Zuazua-Villar, Pedro, Rodriguez, Rene, Meuth, Mark

“…The related PIK-like kinases Ataxia-Telangiectasia Mutated (ATM) and ATM- and Rad3-related (ATR) play major roles in the regulation of cellular responses to…”
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The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells by Meuth, M

“…Alterations of the balanced supply of the precursors of DNA synthesis, the deoxyribonucleoside triphosphates, have dramatic genetic consequences for mammalian…”
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Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells by Meuth, Mark

“…S-phase checkpoints are triggered in tumor cells in response to DNA replication stress caused by the tumor microenvironment or oncogenes. A recent report from…”
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Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene by KANAMORI, M, KON, H, MURAKAMI, Y, NOBUKUNI, T, NOMURA, S, SUGANO, K, MASHIYAMA, S, KUMABE, T, YOSHIMOTO, T, MEUTL, M, SEKIYA, T

“…High-frequent microsatellite instability (MSI-H) was detected in two of the 80 gliomas examined, whlie the other 78 gliomas showed microsatellite stable (MSS)…”
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Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells by Zuazua-Villar, Pedro, Ganesh, Anil, Phear, Geraldine, Gagou, Mary E, Meuth, Mark

“…The replication protein A (RPA)-ssDNA complex formed at arrested replication forks recruits key proteins to activate the ATR-CHK1 signalling cascade. When CHK1…”
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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase by Helleday, Thomas, Bryant, Helen E, Schultz, Niklas, Thomas, Huw D, Parker, Kayan M, Flower, Dan, Lopez, Elena, Kyle, Suzanne, Meuth, Mark, Curtin, Nicola J

“…Poly(ADP-ribose) polymerase (PARP1) facilitates DNA repair by binding to DNA breaks and attracting DNA repair proteins to the site of damage. Nevertheless,…”
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