Search Results - "Meurs, Noah"

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues by Wallace, Martina, Green, Courtney R., Roberts, Lindsay S., Lee, Yujung Michelle, McCarville, Justin L., Sanchez-Gurmaches, Joan, Meurs, Noah, Gengatharan, Jivani M., Hover, Justin D., Phillips, Susan A., Ciaraldi, Theodore P., Guertin, David A., Cabrales, Pedro, Ayres, Janelle S., Nomura, Daniel K., Loomba, Rohit, Metallo, Christian M.

“…Fatty acid synthase (FASN) predominantly generates straight-chain fatty acids using acetyl-CoA as the initiating substrate. However, monomethyl branched-chain…”
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ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch by Zhao, Steven, Torres, AnnMarie, Henry, Ryan A., Trefely, Sophie, Wallace, Martina, Lee, Joyce V., Carrer, Alessandro, Sengupta, Arjun, Campbell, Sydney L., Kuo, Yin-Ming, Frey, Alexander J., Meurs, Noah, Viola, John M., Blair, Ian A., Weljie, Aalim M., Metallo, Christian M., Snyder, Nathaniel W., Andrews, Andrew J., Wellen, Kathryn E.

“…Mechanisms of metabolic flexibility enable cells to survive under stressful conditions and can thwart therapeutic responses. Acetyl-coenzyme A (CoA) plays…”
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Norovirus NS1/2 protein increases glutaminolysis for efficient viral replication by Hafner, Adam, Meurs, Noah, Garner, Ari, Azar, Elaine, Kannan, Aditya, Passalacqua, Karla D, Nagrath, Deepak, Wobus, Christiane E

“…Viruses are obligate intracellular parasites that rely on host cell metabolism for successful replication. Thus, viruses rewire host cell pathways involved in…”
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Driving with Both Feet: Supplementing AKG While Inhibiting BCAT1 Leads to Synthetic Lethality in GBM by Meurs, Noah, Nagrath, Deepak

“…Abstract Understanding how carcinogenesis can expose cancers to synthetically lethal vulnerabilities has been an essential underpinning of development of…”
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Quantifying Metabolic Transfer Mediated by Extracellular Vesicles Using Exo-MFA: An Integrated Empirical and Computational Platform by Achreja, Abhinav, Meurs, Noah, Nagrath, Deepak

“…Extracellular vesicles (EVs) are ubiquitous nanoscale particles released from many different types of cells. They have been shown to contain proteins, DNA,…”
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Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism by Collin de l’Hortet, Alexandra, Takeishi, Kazuki, Guzman-Lepe, Jorge, Morita, Kazutoyo, Achreja, Abhinav, Popovic, Branimir, Wang, Yang, Handa, Kan, Mittal, Anjali, Meurs, Noah, Zhu, Ziwen, Weinberg, Frank, Salomon, Michael, Fox, Ira J., Deng, Chu-Xia, Nagrath, Deepak, Soto-Gutierrez, Alejandro

“…The mechanisms by which steatosis of the liver progresses to non-alcoholic steatohepatitis and end-stage liver disease remain elusive. Metabolic derangements…”
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Long chain monomethyl branched-chain fatty acid levels in human milk vary with gestational weight gain by O'Sullivan, Aifric, Brady, Emer, Lafferty, Lucy, O'Shea, Fiona, O'Regan, Zoe, Meurs, Noah, Baldini, Michelle, Gengatharan, Jivani, Metallo, Christian M., Wallace, Martina

“…•mmBCFA levels in human milk vary with gestational weight gain.•De novo synthesis can account for as much as 50 % of the levels of specific mmBCFAs in murine…”
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Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours by Zhu, Ziwen, Achreja, Abhinav, Meurs, Noah, Animasahun, Olamide, Owen, Sarah, Mittal, Anjali, Parikh, Pooja, Lo, Ting-Wen, Franco-Barraza, Janusz, Shi, Jiaqi, Gunchick, Valerie, Sherman, Mara H., Cukierman, Edna, Pickering, Andrew M., Maitra, Anirban, Sahai, Vaibhav, Morgan, Meredith A., Nagrath, Sunitha, Lawrence, Theodore S., Nagrath, Deepak

“…Branched-chain amino acids (BCAAs) supply both carbon and nitrogen in pancreatic cancers, and increased levels of BCAAs have been associated with increased…”
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Human induced pluripotent stem cell based hepatic-modeling of lipid metabolism associated TM6SF2 E167K variant by Faccioli, Lanuza Ap, Sun, Yiyue, Animasahun, Olamide, Motomura, Takashi, Liu, Zhenghao, Kurihara, Takeshi, Hu, Zhiping, Yang, Bo, Cetin, Zeliha, Baratta, Annalisa M, Shankaran, Ajay, Nenwani, Minal, Altay, Leyla Nurcihan, Huang, Linqi, Meurs, Noah, Franks, Jonathan, Stolz, Donna, Gavlock, Dillon C, Miedel, Mark T, Ostrowska, Alina, Florentino, Rodrigo M, Fox, Ira J, Nagrath, Deepak, Soto-Gutierrez, Alejandro

“…TM6SF2 rs58542926 (E167K) is related to increased prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). Conflicting mouse study…”
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Abstract 236: Genomic loss in cancers enable discovery of metabolic targets for precision cancer therapy via multiobjective flux analysis and machine learning by Achreja, Abhinav, Yu, Tao, Mittal, Anjali, Choppara, Srinadh, Meurs, Noah, Animasahun, Olamide, Jeon, Jin Heon, Mohan, Aradhana, Jayaraman, Anusha, Kulkarni, Reva, Reinhold, Justin, Cusato, Michele, Difeo, Analisa, Lu, Xiongbin, Nagrath, Deepak

“…Abstract Large-scale chromosomal alterations, particularly chromosomal deletions in cancer genomes confer functional advantages to cancer cells via the loss of…”
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Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso‐heptadecanoic Acid Are Inversely Associated With Liver Fat in Children by Sawh, Mary Catherine, Wallace, Martina, Shapiro, Emma, Goyal, Nidhi P., Newton, Kimberly P., Yu, Elizabeth L., Bross, Craig, Durelle, Janis, Knott, Cynthia, Gangoiti, Jon A., Barshop, Bruce A., Gengatharan, Jivani M., Meurs, Noah, Schlein, Alexandra, Middleton, Michael S., Sirlin, Claude B., Metallo, Christian M., Schwimmer, Jeffrey B.

“…ABSTRACT Objectives: We sought to evaluate the relevance of pediatric dairy fat recommendations for children at risk for nonalcoholic fatty liver disease…”
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Dairy Fat Intake, Plasma C15: 0 and Plasma Iso-C17: 0 are Inversely Associated with Liver Fat in Children by Sawh, Mary Catherine, Wallace, Martina, Shapiro, Emma, Goyal, Nidhi P., Newton, Kimberly P., Yu, Elizabeth L., Bross, Craig, Durelle, Janis, Knott, Cynthia, Gangoiti, Jon A., Barshop, Bruce A., Gengatharan, Jivani M., Meurs, Noah, Schlein, Alexandra, Middleton, Michael S., Sirlin, Claude B., Metallo, Christian M., Schwimmer, Jeffrey B.

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Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer by Achreja, Abhinav, Yu, Tao, Mittal, Anjali, Choppara, Srinadh, Animasahun, Olamide, Nenwani, Minal, Wuchu, Fulei, Meurs, Noah, Mohan, Aradhana, Jeon, Jin Heon, Sarangi, Itisam, Jayaraman, Anusha, Owen, Sarah, Kulkarni, Reva, Cusato, Michele, Weinberg, Frank, Kweon, Hye Kyong, Subramanian, Chitra, Wicha, Max S., Merajver, Sofia D., Nagrath, Sunitha, Cho, Kathleen R., DiFeo, Analisa, Lu, Xiongbin, Nagrath, Deepak

“…Recurrent loss-of-function deletions cause frequent inactivation of tumour suppressor genes but often also involve the collateral deletion of essential genes…”
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Porous PDMS‐Based Microsystem (ExoSponge) for Rapid Cost‐Effective Tumor Extracellular Vesicle Isolation and Mass Spectrometry‐Based Metabolic Biomarker Screening by Marvar, Joseph, Kumari, Abha, Onukwugha, Nna‐Emeka, Achreja, Abhinav, Meurs, Noah, Animasahun, Olamide, Roy, Jyotirmoy, Paserba, Miya, Raju, Kruthi Srinivasa, Fortna, Shawn, Ramnath, Nithya, Nagrath, Deepak, Kang, Yoon‐Tae, Nagrath, Sunitha

“…Polydimethylsiloxane (PDMS) is an inexpensive robust polymer that is commonly used as the fundamental fabrication material for soft‐lithography‐based…”
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