Search Results - "Metzler, Scott D."

Review of SPECT collimator selection, optimization, and fabrication for clinical and preclinical imaging by Van Audenhaege, Karen, Van Holen, Roel, Vandenberghe, Stefaan, Vanhove, Christian, Metzler, Scott D., Moore, Stephen C.

“…In single photon emission computed tomography, the choice of the collimator has a major impact on the sensitivity and resolution of the system. Traditional…”
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Quantification of myocardial uptake rate constants in dynamic small-animal SPECT using a cardiac phantom by Johnson, Lindsay C, Guerraty, Marie A, Moore, Stephen C, Metzler, Scott D

“…Myocardial blood flow and myocardial blood flow reserve (MBFR) measurements are often used clinically to quantify coronary microvascular function. Developing…”
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Multimodality assessment of the coronary microvasculature with TIMI frame count versus perfusion PET highlights coronary changes characteristic of coronary microvascular disease by Wayne, Nicole, Wu, Qufei, Moore, Stephen C, Ferrari, Victor A, Metzler, Scott D, Guerraty, Marie A

“…The diagnosis of coronary microvascular disease (CMVD) remains challenging. Perfusion PET-derived myocardial blood flow (MBF) reserve (MBFR) can quantify CMVD…”
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Improving Generalizability of PET DL Algorithms: List-Mode Reconstructions Improve DOTATATE PET Hepatic Lesion Detection Performance by Yang, Xinyi, Silosky, Michael, Wehrend, Jonathan, Litwiller, Daniel V, Nachiappan, Muthiah, Metzler, Scott D, Ghosh, Debashis, Xing, Fuyong, Chin, Bennett B

“…Deep learning (DL) algorithms used for DOTATATE PET lesion detection typically require large, well-annotated training datasets. These are difficult to obtain…”
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Performance evaluation of resolution and sensitivity of C‐SPECT's variable slat‐stack collimator by Sankar, Poopalasingam, Stentz, Dale J., Johnson, Lindsay C., Metzler, Scott D.

“…Background Myocardial perfusion imaging is commonly performed using SPECT, where both general‐purpose and dedicated scanners are available. A limitation with…”
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A unified Fourier theory for time-of-flight PET data by Li, Yusheng, Matej, Samuel, Metzler, Scott D

“…Fully 3D time-of-flight (TOF) PET scanners offer the potential of previously unachievable image quality in clinical PET imaging. TOF measurements add another…”
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Analytic Determination of Rectangular-Pinhole Sensitivity With Penetration by Metzler, Scott D., Moore, Stephen C.

“…Modern small-animal SPECT systems use multiple pinhole collimators per detector to increase sensitivity while still maintaining high resolution. This…”
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A Novel Mouse Model of Radiation-Induced Cardiac Injury Reveals Biological and Radiological Biomarkers of Cardiac Dysfunction with Potential Clinical Relevance by Dreyfuss, Alexandra D, Goia, Denisa, Shoniyozov, Khayrullo, Shewale, Swapnil V, Velalopoulou, Anastasia, Mazzoni, Susan, Avgousti, Harris, Metzler, Scott D, Bravo, Paco E, Feigenberg, Steven J, Ky, Bonnie, Verginadis, Ioannis I, Koumenis, Constantinos

“…Radiation-induced cardiotoxicity is a significant concern in thoracic oncology patients. However, the basis for this disease pathology is not well…”
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Image reconstructions from super‐sampled data sets with resolution modeling in PET imaging by Li, Yusheng, Matej, Samuel, Metzler, Scott D.

“…Purpose: Spatial resolution in positron emission tomography (PET) is still a limiting factor in many imaging applications. To improve the spatial resolution…”
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Transmission-less attenuation estimation from time-of-flight PET histo-images using consistency equations by Li, Yusheng, Defrise, Michel, Metzler, Scott D, Matej, Samuel

“…In positron emission tomography (PET) imaging, attenuation correction with accurate attenuation estimation is crucial for quantitative patient studies. Recent…”
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SPECT quantification of myocardial blood flow: Another step toward widespread availability by Guerraty, Marie A., Metzler, Scott D., Bravo, Paco E.

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Geometric Sensitivity of a Pinhole Collimator by Jacobowitz, Howard, Metzler, Scott D.

“…Geometric sensitivity for single photon emission computerized tomography (SPECT) is given by a double integral over the detection plane. It would be useful to…”
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LOR-interleaving image reconstruction for PET imaging with fractional-crystal collimation by Li, Yusheng, Matej, Samuel, Karp, Joel S, Metzler, Scott D

“…Positron emission tomography (PET) has become an important modality in medical and molecular imaging. However, in most PET applications, the resolution is…”
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Reconstruction of multiple-pinhole micro-SPECT data using origin ensembles by Lyon, Morgan C., Sitek, Arkadiusz, Metzler, Scott D., Moore, Stephen C.

“…Purpose: The authors are currently developing a dual-resolution multiple-pinhole microSPECT imaging system based on three large NaI(Tl) gamma cameras. Two…”
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Diagnostic accuracy of SPECT and PET myocardial perfusion imaging in patients with left bundle branch block or ventricular-paced rhythm by Vidula, Mahesh K., Wiener, Philip, Selvaraj, Senthil, Khan, Muhammad Shoaib, Salam, Usman Abdul, Rojulpote, Chaitanya, Metzler, Scott D., Denduluri, Srinivas, Guerraty, Marie, Julien, Howard, Bravo, Paco E.

“…The difference in diagnostic accuracy of coronary artery disease (CAD) between vasodilator SPECT and PET myocardial perfusion imaging (MPI) in patients with…”
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Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression by Chin, Bennett B, Hjelemand, Anita, Rich, Jeremy, Song, Haijing, Lascola, Christopher, Storms, Robert, McLendon, Roger, Reiman, Robert, Greer, Kim L, Metzler, Scott D, McDougald, Darryl, Dai, Diana, Vaidyanathan, Ganesan

“…Chloroquine has demonstrated high affinity for aldehyde dehydrogenase 1A1 (ALDH1), an enzyme expressed in the highly tumorigenic CD133+ brain tumor initiating…”
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Special Section Guest Editorial: Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine by Metzler, Scott D, Matej, Samuel, Stayman, J. Webster

“…Guest editors Scott D. Metzler, Samuel Matej, and J. Webster Stayman provide an introduction to the Special Section on Three-Dimensional Image Reconstruction…”
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Investigation of imaging properties for submillimeter rectangular pinholes by Xia, Dan, Moore, Stephen C., Park, Mi‐Ae, Cervo, Morgan, Metzler, Scott D.

“…Purpose: Recently, a multipinhole collimator with inserts that have both rectangular apertures and rectangular fields of view (FOVs) has been proposed for…”
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Amyloid-β imaging with PET in Alzheimer’s disease: is it feasible with current radiotracers and technologies? by Moghbel, Mateen C., Saboury, Babak, Basu, Sandip, Metzler, Scott D., Torigian, Drew A., Långström, Bengt, Alavi, Abass

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Analytic determination of the resolution-equivalent effective diameter of a pinhole collimator by Accorsi, R., Metzler, S.D.

“…To account for photon penetration, the formulas used to calculate the geometric resolution of a pinhole collimator use an equivalent diameter d/sub e/ rather…”
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