Search Results - "Metzis, Vicki"

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation by Blassberg, Robert, Patel, Harshil, Watson, Thomas, Gouti, Mina, Metzis, Vicki, Delás, M. Joaquina, Briscoe, James

“…WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces mesodermal tissue…”
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The route to spinal cord cell types: a tale of signals and switches by Gouti, Mina, Metzis, Vicki, Briscoe, James

“…Highlights • The anterior nervous system and spinal cord have distinct developmental origins • The spinal cord shares a common lineage with paraxial mesoderm •…”
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Nervous System Regionalization Entails Axial Allocation before Neural Differentiation by Metzis, Vicki, Steinhauser, Sebastian, Pakanavicius, Edvinas, Gouti, Mina, Stamataki, Despina, Ivanovitch, Kenzo, Watson, Thomas, Rayon, Teresa, Mousavy Gharavy, S. Neda, Lovell-Badge, Robin, Luscombe, Nicholas M., Briscoe, James

“…Neural induction in vertebrates generates a CNS that extends the rostral-caudal length of the body. The prevailing view is that neural cells are initially…”
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ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex by Semprich, Claudia I, Davidson, Lindsay, Amorim Torres, Adriana, Patel, Harshil, Briscoe, James, Metzis, Vicki, Storey, Kate G

“…Fibroblast growth factor (FGF) is a neural inducer in many vertebrate embryos, but how it regulates chromatin organization to coordinate the activation of…”
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Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease by Lu, Hao, Galeano, Maria C Rondón, Ott, Elisabeth, Kaeslin, Geraldine, Kausalya, P Jaya, Kramer, Carina, Ortiz-Brüchle, Nadina, Hilger, Nadescha, Metzis, Vicki, Hiersche, Milan, Tay, Shang Yew, Tunningley, Robert, Vij, Shubha, Courtney, Andrew D, Whittle, Belinda, Wühl, Elke, Vester, Udo, Hartleben, Björn, Neuber, Steffen, Frank, Valeska, Little, Melissa H, Epting, Daniel, Papathanasiou, Peter, Perkins, Andrew C, Wright, Graham D, Hunziker, Walter, Gee, Heon Yung, Otto, Edgar A, Zerres, Klaus, Hildebrandt, Friedhelm, Roy, Sudipto, Wicking, Carol, Bergmann, Carsten

“…Sudipto Roy, Carol Wicking, Carsten Bergmann and colleagues report that mutations in DZIP1L cause autosomal recessive polycystic kidney disease (ARPKD)…”
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Unmasking the ciliopathies: craniofacial defects and the primary cilium by Cortés, Claudio R, Metzis, Vicki, Wicking, Carol

“…Over the past decade, the primary cilium has emerged as a pivotal sensory organelle that acts as a major signaling hub for a number of developmental signaling…”
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Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells by Gabryšová, Leona, Alvarez-Martinez, Marisol, Luisier, Raphaëlle, Cox, Luke S., Sodenkamp, Jan, Hosking, Caroline, Pérez-Mazliah, Damián, Whicher, Charlotte, Kannan, Yashaswini, Potempa, Krzysztof, Wu, Xuemei, Bhaw, Leena, Wende, Hagen, Sieweke, Michael H., Elgar, Greg, Wilson, Mark, Briscoe, James, Metzis, Vicki, Langhorne, Jean, Luscombe, Nicholas M., O’Garra, Anne

“…In the version of this article initially published, the Supplementary Data file was an incorrect version. The correct version is now provided. The error has…”
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Patched1 is required in neural crest cells for the prevention of orofacial clefts by Metzis, Vicki, Courtney, Andrew D, Kerr, Markus C, Ferguson, Charles, Rondón Galeano, Maria C, Parton, Robert G, Wainwright, Brandon J, Wicking, Carol

“…Defects such as cleft lip with or without cleft palate (CL/P) are among the most common craniofacial birth defects in humans. In many cases, the underlying…”
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Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb by Butterfield, Natalie C, Metzis, Vicki, McGlinn, Edwina, Bruce, Stephen J, Wainwright, Brandon J, Wicking, Carol

“…The vertebrate hedgehog receptor patched 1 (Ptc1) is crucial for negative regulation of the sonic hedgehog (Shh) pathway during anterior-posterior patterning…”
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Inactivation of Patched1 in the Mouse Limb Has Novel Inhibitory Effects on the Chondrogenic Program by Bruce, Stephen J., Butterfield, Natalie C., Metzis, Vicki, Town, Liam, McGlinn, Edwina, Wicking, Carol

“…The bones of the vertebrate limb form by the process of endochondral ossification, whereby limb mesenchyme condenses to form an intermediate cartilage scaffold…”
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Heads or tails: making the spinal cord by Needham, Julia, Metzis, Vicki

“…The central nervous system contains a vast array of cell types that are produced along the length of the rostrocaudal axis. This diversity in cell identity is…”
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Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks by Exelby, Katherine, Herrera-Delgado, Edgar, Perez, Lorena Garcia, Perez-Carrasco, Ruben, Sagner, Andreas, Metzis, Vicki, Sollich, Peter, Briscoe, James

“…During development, gene regulatory networks allocate cell fates by partitioning tissues into spatially organised domains of gene expression. How the sharp…”
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Building consensus in neuromesodermal research: Current advances and future biomedical perspectives by Binagui-Casas, Anahí, Dias, André, Guillot, Charlène, Metzis, Vicki, Saunders, Dillan

“…The development of the vertebrate body axis relies on the activity of different populations of axial progenitors, including neuromesodermal progenitors…”
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c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells by Gabryšová, Leona, Alvarez-Martinez, Marisol, Luisier, Raphaëlle, Cox, Luke S., Sodenkamp, Jan, Hosking, Caroline, Pérez-Mazliah, Damián, Whicher, Charlotte, Kannan, Yashaswini, Potempa, Krzysztof, Wu, Xuemei, Bhaw, Leena, Wende, Hagen, Sieweke, Michael H., Elgar, Greg, Wilson, Mark, Briscoe, James, Metzis, Vicki, Langhorne, Jean, Luscombe, Nicholas M., O’Garra, Anne

“…The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4 + T cells in vitro. However, the global effects of c-Maf on diverse immune…”
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The route to spinal cord cell types: a tale of signals and switches: Special Issue: Organogenesis by Gouti, Mina, Metzis, Vicki, Briscoe, James

“…Understanding the mechanisms that control induction and elaboration of the vertebrate central nervous system (CNS) requires an analysis of the extrinsic…”
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Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease by Lu, Hao, Rondón Galeano, Maria C, Ott, Elisabeth, Kaeslin, Geraldine, Kausalya, P Jaya, Kramer, Carina, Ortiz-Brüchle, Nadina, Hilger, Nadescha, Metzis, Vicki, Hiersche, Milan, Tay, Shang Yew, Tunningley, Robert, Vij, Shubha, Courtney, Andrew D, Whittle, Belinda, Wühl, Elke, Vester, Udo, Hartleben, Björn, Neuber, Steffen, Frank, Valeska, Little, Melissa H, Epting, Daniel, Papathanasiou, Peter, Perkins, Andrew C, Wright, Graham D, Hunziker, Walter, Gee, Heon Yung, Otto, Edgar A, Zerres, Klaus, Hildebrandt, Friedhelm, Roy, Sudipto, Wicking, Carol, Bergmann, Carsten

“…Autosomal recessive polycystic kidney disease (ARPKD), usually considered to be a genetically homogeneous disease caused by mutations in PKHD1, has been…”
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Patched1 is essential for nasal pit invagination in mouse by Metzis, Vicki, Courtney, Andrew, Ferguson, Charles, Cooper, Ashley, Wainwright, Brandon, Wicking, Carol

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The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors by Town, Liam, McGlinn, Edwina, Fiorenza, Salvatore, Metzis, Vicki, Butterfield, Natalie C., Richman, Joy M., Wicking, Carol

“…Pitrm1 is a zinc metalloendopeptidase that has been implicated in Alzheimer's disease and mitochondrial peptide degradation, but to date no major role in…”
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Expression of the NET family member Zfp503 is regulated by hedgehog and BMP signaling in the limb by McGlinn, Edwina, Richman, Joy M., Metzis, Vicki, Town, Liam, Butterfield, Natalie C., Wainwright, Brandon J., Wicking, Carol

“…The NET/Nlz family of zinc finger transcription factors contribute to aspects of developmental growth and patterning across evolutionarily diverse species. To…”
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Boundary precision in the ventral neural tube by Exelby, Katherine, Herrera, Edgar, Metzis, Vicki, Briscoe, James

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