Search Results - "Metzak, Paul"

tDCS for the treatment of negative symptoms in youth at clinical-high-risk for psychosis: A feasibility study by Metzak, Paul D., DeMayo, Marilena M., Brummitt, Kali, Bray, Signe, MacMaster, Frank, Harris, Ashley, McGirr, Alexander, Addington, Jean

“…•tDCS is a potential tool to treat negative symptoms in youth at risk for psychosis.•An intensive 3-week protocol of tDCS and CBT was found to be feasible and…”
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Brain changes associated with negative symptoms in clinical high risk for psychosis: A systematic review by Metzak, Paul D., Devoe, Daniel J., Iwaschuk, Amanda, Braun, Amy, Addington, Jean

“…•Negative symptoms of schizophrenia often occur early in those at clinical high risk.•The biological basis of negative symptoms are poorly understood in those…”
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Social functioning and brain imaging in individuals at clinical high-risk for psychosis: A systematic review by Metzak, Paul D., Farris, Megan S., Placsko, Thea, Braun, Amy, Bonneville, Dominique, Brummitt, Kali, Chu, Monica, Addington, Jean

“…Impairments in social functioning are a core impairment in psychosis and are associated with poor outcomes. These deficits are found in those at clinical…”
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Age-related changes in topological patterns of large-scale brain functional networks during memory encoding and recognition by Wang, Liang, Li, Yanfang, Metzak, Paul, He, Yong, Woodward, Todd S.

“…In this study we used functional magnetic resonance imaging to investigate age-related changes in large-scale brain functional networks during memory encoding…”
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Functional brain networks underlying detection and integration of disconfirmatory evidence by Lavigne, Katie M, Metzak, Paul D, Woodward, Todd S

“…Processing evidence that disconfirms a prior interpretation is a fundamental aspect of belief revision, and has clear social and clinical relevance. This…”
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Epoch-specific functional networks involved in working memory by Woodward, Todd S., Feredoes, Eva, Metzak, Paul D., Takane, Yoshio, Manoach, Dara S.

“…Working memory (WM) is not a unitary construct. There are distinct processes involved in encoding information, maintaining it on-line, and using it to guide…”
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Testing a deep convolutional neural network for automated hippocampus segmentation in a longitudinal sample of healthy participants by Nogovitsyn, Nikita, Souza, Roberto, Muller, Meghan, Srajer, Amelia, Hassel, Stefanie, Arnott, Stephen R., Davis, Andrew D., Hall, Geoffrey B., Harris, Jacqueline K., Zamyadi, Mojdeh, Metzak, Paul D., Ismail, Zahinoor, Bray, Signe L., Lebel, Catherine, Addington, Jean M., Milev, Roumen, Harkness, Kate L., Frey, Benicio N., Lam, Raymond W., Strother, Stephen C., Goldstein, Benjamin I., Rotzinger, Susan, Kennedy, Sidney H., MacQueen, Glenda M.

“…Subtle changes in hippocampal volumes may occur during both physiological and pathophysiological processes in the human brain. Assessing hippocampal volumes…”
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Aberrant connectivity during self–other source monitoring in schizophrenia by Wang, Liang, Metzak, Paul D, Woodward, Todd S

“…Abstract Numerous investigations into schizophrenia have reported impairment in self–other source monitoring, and studies on healthy subjects have suggested…”
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Hippocampal tail volume as a predictive biomarker of antidepressant treatment outcomes in patients with major depressive disorder: a CAN-BIND report by Nogovitsyn, Nikita, Muller, Meghan, Souza, Roberto, Hassel, Stefanie, Arnott, Stephen R, Davis, Andrew D, Hall, Geoffrey B, Harris, Jacqueline K, Zamyadi, Mojdeh, Metzak, Paul D, Ismail, Zahinoor, Downar, Jonathan, Parikh, Sagar V, Soares, Claudio N, Addington, Jean M, Milev, Roumen, Harkness, Kate L, Frey, Benicio N, Lam, Raymond W, Strother, Stephen C, Rotzinger, Susan, Kennedy, Sidney H, MacQueen, Glenda M

“…Finding a clinically useful neuroimaging biomarker that can predict treatment response in patients with major depressive disorder (MDD) is challenging, in part…”
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Impaired efficiency of functional networks underlying episodic memory-for-context in schizophrenia by Wang, Liang, Metzak, Paul D, Honer, William G, Woodward, Todd S

“…Memory for context and episodic memory have been identified as primary contributors to cognitive impairments in schizophrenia. This study examined neural…”
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Aberrant limbic brain structures in young individuals at risk for mental illness by Nogovitsyn, Nikita, Souza, Roberto, Muller, Meghan, Srajer, Amelia, Metzak, Paul D., Hassel, Stefanie, Ismail, Zahinoor, Protzner, Andrea, Bray, Signe L., Lebel, Catherine, MacIntosh, Bradley J., Goldstein, Benjamin I., Wang, JianLi, Kennedy, Sidney H., Addington, Jean, MacQueen, Glenda M.

“…Aim Alterations in limbic structures may be present before the onset of serious mental illness, but whether subfield‐specific limbic brain changes parallel…”
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Hallucination-Specific structure-function associations in schizophrenia by Roes, Meighen M., Yin, John, Taylor, Laura, Metzak, Paul D., Lavigne, Katie M., Chinchani, Abhijit, Tipper, Christine M., Woodward, Todd S.

“…•Frontotemporal thinning linked with language network hyperactivity in hallucinators.•Hallucinators’ language network hyperactivity specific to passive speech…”
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Functional brain networks involved in reality monitoring by Metzak, Paul D., Lavigne, Katie M., Woodward, Todd S.

“…Source monitoring refers to the recollection of variables that specify the context and conditions in which a memory episode was encoded. This process involves…”
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Cerebello-limbic functional connectivity patterns in youth at clinical high risk for psychosis by Nogovitsyn, Nikita, Metzak, Paul D., Casseb, Raphael F., Souza, Roberto, Harris, Jacqueline K., Prati, Lionel M., Zamyadi, Mojdeh, Bray, Signe L., Lebel, Catherine, Hassel, Stefanie, Strother, Stephen, Goldstein, Benjamin I., Wang, JianLi, Kennedy, Sidney H., MacQueen, Glenda M., Addington, Jean

“…Youth at clinical high risk (CHR) for psychosis can present not only with characteristic attenuated psychotic symptoms but also may have other comorbid…”
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Brain connectomes in youth at risk for serious mental illness: a longitudinal perspective by Shakeel, Mohammed K., Metzak, Paul D., Lasby, Mike, Long, Xiangyu, Souza, Roberto, Bray, Signe, Goldstein, Benjamin I., MacQueen, Glenda, Wang, JianLi, Kennedy, Sidney H., Addington, Jean, Lebel, Catherine

“…Identifying biomarkers for serious mental illnesses (SMI) has significant implications for prevention and early intervention. In the current study, changes in…”
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Brain connectomes in youth at risk for serious mental illness: an exploratory analysis by Metzak, Paul D, Shakeel, Mohammed K, Long, Xiangyu, Lasby, Mike, Souza, Roberto, Bray, Signe, Goldstein, Benjamin I, MacQueen, Glenda, Wang, JianLi, Kennedy, Sidney H, Addington, Jean, Lebel, Catherine

“…Identifying early biomarkers of serious mental illness (SMI)-such as changes in brain structure and function-can aid in early diagnosis and treatment. Whole…”
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Functional brain networks involved in lexical decision by Wong, Samantha Tze Sum, Goghari, Vina M., Sanford, Nicole, Lim, Ryan, Clark, Cameron, Metzak, Paul D., Rossell, Susan L., Menon, Mahesh, Woodward, Todd S.

“…•A multidimensional fMRI analysis in lexical decision (LD) was used.•Manipulating the “wordlikeness” of the LD stimuli facilitated interpretation.•Finite…”
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Compensatory motor network connectivity is associated with motor sequence learning after subcortical stroke by Wadden, Katie P., Woodward, Todd S., Metzak, Paul D., Lavigne, Katie M., Lakhani, Bimal, Auriat, Angela M., Boyd, Lara A.

“…•We evaluated brain connectivity during motor tracking in healthy and stroke participants.•Healthy subjects demonstrated connectivity within a widely disturbed…”
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Reduced functional connectivity during controlled semantic integration in schizophrenia: A multivariate approach by Woodward, Todd S., Tipper, Christine M., Leung, Alexander L., Lavigne, Katie M., Sanford, Nicole, Metzak, Paul D.

“…Impairment in controlled semantic association is a central feature of schizophrenia, and the goal of the current functional magnetic resonance imaging study…”
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Left-dominant temporal-frontal hypercoupling in schizophrenia patients with hallucinations during speech perception by Lavigne, Katie M, Rapin, Lucile A, Metzak, Paul D, Whitman, Jennifer C, Jung, Kwanghee, Dohen, Marion, Lœvenbruck, Hélène, Woodward, Todd S

“…Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions…”
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