Search Results - "Metselaar, J."

A model including sarcopenia surpasses the MELD score in predicting waiting list mortality in cirrhotic liver transplant candidates: A competing risk analysis in a national cohort by van Vugt, Jeroen Laurens Ad, Alferink, Louise Johanna Maria, Buettner, Stefan, Gaspersz, Marcia Patricia, Bot, Daphne, Darwish Murad, Sarwa, Feshtali, Shirin, van Ooijen, Peter Martinus Adranius, Polak, Wojciech Grzegorz, Porte, Robert Jack, van Hoek, Bart, van den Berg, Aad Pieter, Metselaar, Herold J, IJzermans, Jan Nicolaas Maria

“…[Display omitted] •Sarcopenia is associated with waiting list mortality in liver transplant patients.•Adding sarcopenia to the MELD score does not have any…”
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Nonalcoholic Fatty Liver Disease in The Rotterdam Study: About Muscle Mass, Sarcopenia, Fat Mass, and Fat Distribution by Alferink, Louise Johanna Maria, Trajanoska, Katerina, Erler, Nicole Stephanie, Schoufour, Josje Dorothea, Knegt, Robert Jacobus, Ikram, M. Arfan, Janssen, Harry Leonardus Antonius, Franco, Oscar H., Metselaar, Herold J., Rivadeneira, Fernando, Darwish Murad, Sarwa

“…ABSTRACT Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. Obesity is a major risk factor for NAFLD and recently, low…”
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Everolimus With Reduced Tacrolimus Improves Renal Function in De Novo Liver Transplant Recipients: A Randomized Controlled Trial by De Simone, P., Nevens, F., De Carlis, L., Metselaar, H. J., Beckebaum, S., Saliba, F., Jonas, S., Sudan, D., Fung, J., Fischer, L., Duvoux, C., Chavin, K. D., Koneru, B., Huang, M. A., Chapman, W. C., Foltys, D., Witte, S., Jiang, H., Hexham, J. M., Junge, G.

“…In a prospective, multicenter, open‐label study, de novo liver transplant patients were randomized at day 30±5 to (i) everolimus initiation with tacrolimus…”
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Calcineurin Inhibitors Stimulate and Mycophenolic Acid Inhibits Replication of Hepatitis E Virus by Wang, Yijin, Zhou, Xinying, Debing, Yannick, Chen, Kan, Van Der Laan, Luc J.W, Neyts, Johan, Janssen, Harry L.A, Metselaar, Herold J, Peppelenbosch, Maikel P, Pan, Qiuwei

“…Background & Aims Many recipients of organ transplants develop chronic hepatitis, due to infection with the hepatitis E virus (HEV). Although chronic HEV…”
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Microbiomics, Metabolomics, Predicted Metagenomics, and Hepatic Steatosis in a Population‐Based Study of 1,355 Adults by Alferink, Louise J.M., Radjabzadeh, Djawad, Erler, Nicole S., Vojinovic, Dina, Medina‐Gomez, Carolina, Uitterlinden, André G., Knegt, Robert J., Amin, Najaf, Ikram, M. Arfan, Janssen, Harry L.A., Kiefte‐de Jong, Jessica C., Metselaar, Herold J., Duijn, Cornelia M., Kraaij, Robert, Darwish Murad, Sarwa

“…Background and Aims Previous small studies have appraised the gut microbiome (GM) in steatosis, but large‐scale studies are lacking. We studied the association…”
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Modeling rotavirus infection and antiviral therapy using primary intestinal organoids by Yin, Yuebang, Bijvelds, Marcel, Dang, Wen, Xu, Lei, van der Eijk, Annemiek A., Knipping, Karen, Tuysuz, Nesrin, Dekkers, Johanna F., Wang, Yijin, de Jonge, Jeroen, Sprengers, Dave, van der Laan, Luc J.W., Beekman, Jeffrey M., ten Berge, Derk, Metselaar, Herold J., de Jonge, Hugo, Koopmans, Marion P.G., Peppelenbosch, Maikel P., Pan, Qiuwei

“…•3D-based primary intestinal organoids support the infection of both experimental and patient-derived rotavirus strains.•Rotavirus infection provokes the…”
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Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin by Chen, Y, Tezcan, O, Li, D, Beztsinna, N, Lou, B, Etrych, T, Ulbrich, K, Metselaar, J M, Lammers, T, Hennink, W E

“…Multidrug resistance (MDR) contributes to failure of chemotherapy. We here show that biodegradable polymeric nanogels are able to overcome MDR via folic acid…”
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Modulation of the cellular immune system by intravenous immunoglobulin by Tha-In, Thanyalak, Bayry, Jagadeesh, Metselaar, Herold J, Kaveri, Srini V, Kwekkeboom, Jaap

“…Intravenous immunoglobulin (IVIg) is therapeutically used in a variety of immune-mediated diseases. The beneficial effects of IVIg in auto-antibody-mediated…”
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Trends in liver transplantation for primary biliary cholangitis in Europe over the past three decades by Harms, Maren H., Janssen, Quisette P., Adam, Rene, Duvoux, Christophe, Mirza, Darius, Hidalgo, Ernest, Watson, Christopher, Wigmore, Stephen J., Pinzani, Massimo, Isoniemi, Helena, Pratschke, Johann, Zieniewicz, Krzysztof, Klempnauer, Jurgen L., Bennet, William, Karam, Vincent, van Buuren, Henk R., Hansen, Bettina E., Metselaar, Herold J.

“…Summary Background The importance of primary biliary cholangitis as an indication for liver transplantation has probably been influenced by the introduction of…”
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Therapeutic drug monitoring of immunosuppressive drugs in hepatology and gastroenterology by Udomkarnjananun, Suwasin, Francke, Marith I., De Winter, Brenda C.M., Mulder, Midas B., Baan, Carla C., Metselaar, Herold J., den Hoed, Caroline M., Hesselink, Dennis A.

“…Immunosuppressive drugs have been key to the success of liver transplantation and are essential components of the treatment of inflammatory bowel disease (IBD)…”
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Renal Function at Two Years in Liver Transplant Patients Receiving Everolimus: Results of a Randomized, Multicenter Study by Saliba, F., De Simone, P., Nevens, F., De Carlis, L., Metselaar, H. J., Beckebaum, S., Jonas, S., Sudan, D., Fischer, L., Duvoux, C., Chavin, K. D., Koneru, B., Huang, M. A., Chapman, W. C., Foltys, D., Dong, G., Lopez, P. M., Fung, J., Junge, G.

“…In a 24‐month prospective, randomized, multicenter, open‐label study, de novo liver transplant patients were randomized at 30 days to everolimus (EVR) +…”
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A Randomized, Controlled Study to Assess the Conversion From Calcineurin‐Inhibitors to Everolimus After Liver Transplantation—PROTECT by Fischer, L., Klempnauer, J., Beckebaum, S., Metselaar, H. J., Neuhaus, P., Schemmer, P., Settmacher, U., Heyne, N., Clavien, P‐A., Muehlbacher, F., Morard, I., Wolters, H., Vogel, W., Becker, T., Sterneck, M., Lehner, F., Klein, C., Kazemier, G., Pascher, A., Schmidt, J., Rauchfuss, F., Schnitzbauer, A., Nadalin, S., Hack, M., Ladenburger, S., Schlitt, H. J.

“…Posttransplant immunosuppression with calcineurin inhibitors (CNIs) is associated with impaired renal function, while mTor inhibitors such as everolimus may…”
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Biomarkers to assess graft quality during conventional and machine preservation in liver transplantation by Verhoeven, Cornelia J, Farid, Waqar R.R, de Jonge, Jeroen, Metselaar, Herold J, Kazemier, Geert, van der Laan, Luc J.W

“…Summary A global rising organ shortage necessitates the use of extended criteria donors (ECD) for liver transplantation (LT). However, poor preservation and…”
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Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis by Metselaar, J M, van den Berg, W B, Holthuysen, A E M, Wauben, M H M, Storm, G, van Lent, P L E M

“…Objective: To investigate the effect of a single intravenous treatment with glucocorticoids (GC) encapsulated in long-circulating PEG-liposomes on both joint…”
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Counter-regulation of rejection activity against human liver grafts by donor PD-L1 and recipient PD-1 interaction by Shi, Xiao-Lei, Mancham, Shanta, Hansen, Bettina E, de Knegt, Robert J, de Jonge, Jeroen, van der Laan, Luc J.W, Rivadeneira, Fernando, Metselaar, Herold J, Kwekkeboom, Jaap

“…Graphical abstract…”
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Decellularization of Whole Human Liver Grafts Using Controlled Perfusion for Transplantable Organ Bioscaffolds by Verstegen, Monique M A, Willemse, Jorke, van den Hoek, Sjoerd, Kremers, Gert-Jan, Luider, Theo M, van Huizen, Nick A, Willemssen, Francois E J A, Metselaar, Herold J, IJzermans, Jan N M, van der Laan, Luc J W, de Jonge, Jeroen

“…Liver transplantation is the only effective treatment for end-stage liver disease, but absolute donor shortage remains a limiting factor. Recent advances in…”
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Hepatocyte‐derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation by Farid, Waqar R. R., Pan, Qiuwei, van der Meer, Adriaan J. P., de Ruiter, Petra E., Ramakrishnaiah, Vedashree, de Jonge, Jeroen, Kwekkeboom, Jaap, Janssen, Harry L. A., Metselaar, Herold J., Tilanus, Hugo W., Kazemier, Geert, van der Laan, Luc J.W.

“…Recent animal and human studies have highlighted the potential of hepatocyte‐derived microRNAs (HDmiRs) in serum as early, stable, sensitive, and specific…”
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Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury by Cao, Wanlu, Chen, Kan, Bolkestein, Michiel, Yin, Yuebang, Verstegen, Monique M.A., Bijvelds, Marcel J.C., Wang, Wenshi, Tuysuz, Nesrin, ten Berge, Derk, Sprengers, Dave, Metselaar, Herold J., van der Laan, Luc J.W., Kwekkeboom, Jaap, Smits, Ron, Peppelenbosch, Maikel P., Pan, Qiuwei

“…Adult liver stem cells are usually maintained in a quiescent/slow-cycling state. However, a proliferative population, marked by leucine-rich repeat-containing…”
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Similar liver transplantation survival with selected cardiac death donors and brain death donors by Dubbeld, J., Hoekstra, H., Farid, W., Ringers, J., Porte, R. J., Metselaar, H. J., Baranski, A. G., Kazemier, G., van den Berg, A. P., van Hoek, B.

“…Background: The outcome of orthotopic liver transplantation (OLT) with controlled graft donation after cardiac death (DCD) is usually inferior to that with…”
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Nanobody-liposomes as novel cancer vaccine platform to efficiently stimulate T cell immunity by Bouma, R.G., Nijen Twilhaar, M.K., Brink, H.J., Affandi, A.J., Mesquita, B.S., Olesek, K., van Dommelen, J.M.A., Heukers, R., de Haas, A.M., Kalay, H., Ambrosini, M., Metselaar, J.M., van Rooijen, A., Storm, G., Oliveira, S., van Kooyk, Y., den Haan, J.M.M.

“…[Display omitted] •Liposomes can be decorated with DC-SIGN- or CD169-specific nanobodies.•Nanobody liposomes specifically bind to CD169+ and/or DC-SIGN+…”
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