Search Results - "Metruccio, Matteo M. E."

Mucosal fluid glycoprotein DMBT1 suppresses twitching motility and virulence of the opportunistic pathogen Pseudomonas aeruginosa by Li, Jianfang, Metruccio, Matteo M E, Evans, David J, Fleiszig, Suzanne M J

“…It is generally thought that mucosal fluids protect underlying epithelial surfaces against opportunistic infection via their antimicrobial activity. However,…”
Get full text

A novel phase variation mechanism in the meningococcus driven by a ligand-responsive repressor and differential spacing of distal promoter elements by Metruccio, Matteo M E, Pigozzi, Eva, Roncarati, Davide, Berlanda Scorza, Francesco, Norais, Nathalie, Hill, Stuart A, Scarlato, Vincenzo, Delany, Isabel

“…Phase variable expression, mediated by high frequency reversible changes in the length of simple sequence repeats, facilitates adaptation of bacterial…”
Get full text

RNA Chaperone Hfq Is Involved in Stress Response and Virulence in Neisseria meningitidis and Is a Pleiotropic Regulator of Protein Expression by Fantappiè, Laura, Metruccio, Matteo M.E, Seib, Kate L, Oriente, Francesca, Cartocci, Elena, Ferlicca, Francesca, Giuliani, Marzia M, Scarlato, Vincenzo, Delany, Isabel

“…The well-conserved protein Hfq has emerged as the key modulator of riboregulation in bacteria. This protein is thought to function as an RNA chaperone and to…”
Get full text

Corneal surface glycosylation is modulated by IL‐1R and Pseudomonas aeruginosa challenge but is insufficient for inhibiting bacterial binding by Jolly, Amber L., Agarwal, Paresh, Metruccio, Matteo M. E., Spiciarich, David R., Evans, David J., Bertozzi, Carolyn R., Fleiszig, Suzanne M. J.

“…ABSTRACT Cell surface glycosylation is thought to be involved in barrier function against microbes at mucosal surfaces. Previously we showed that the…”
Get full text

Propionibacterium acnes host cell tropism contributes to vimentin‐mediated invasion and induction of inflammation by Mak, Tim N., Fischer, Natalie, Laube, Britta, Brinkmann, Volker, Metruccio, Matteo M. E., Sfanos, Karen S., Mollenkopf, Hans‐Joachim, Meyer, Thomas F., Brüggemann, Holger

“…Summary The contribution of the human microbiota to health and disease is poorly understood. Propionibacterium acnes is a prominent member of the skin…”
Get full text

The Hfq-Dependent Small Noncoding RNA NrrF Directly Mediates Fur-Dependent Positive Regulation of Succinate Dehydrogenase in Neisseria meningitidis by METRUCCIO, Matteo M. E, FANTAPPIE, Laura, SERRUTO, Davide, MUZZI, Alessandro, RONCARATI, Davide, DONATI, Claudio, SCARLATO, Vincenzo, DELANYL, Isabel

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

OxyR tightly regulates catalase expression in Neisseria meningitidis through both repression and activation mechanisms by Ieva, Raffaele, Roncarati, Davide, Metruccio, Matteo M. E., Seib, Kate L., Scarlato, Vincenzo, Delany, Isabel

“…Summary Mechanisms for coping with oxidative stress (OS) are crucial for the survival of pathogenic Neisseria spp. in the human host. In this study we…”
Get full text

Type IV Pili Can Mediate Bacterial Motility within Epithelial Cells by Nieto, Vincent, Kroken, Abby R, Grosser, Melinda R, Smith, Benjamin E, Metruccio, Matteo M E, Hagan, Patrick, Hallsten, Mary E, Evans, David J, Fleiszig, Suzanne M J

“…is among bacterial pathogens capable of twitching motility, a form of surface-associated movement dependent on type IV pili (T4P). Previously, we showed that…”
Get full text

Nerve‐associated transient receptor potential ion channels can contribute to intrinsic resistance to bacterial adhesion in vivo by Wan, Stephanie J., Datta, Ananya, Flandrin, Orneika, Metruccio, Matteo M. E., Ma, Sophia, Nieto, Vincent, Kroken, Abby R., Hill, Rose Z., Bautista, Diana M., Evans, David J., Fleiszig, Suzanne M. J.

“…The cornea of the eye differs from other mucosal surfaces in that it lacks a viable bacterial microbiome and by its unusually high density of sensory nerve…”
Get full text

IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea by Wan, Stephanie J, Sullivan, Aaron B, Shieh, Peyton, Metruccio, Matteo M E, Evans, David J, Bertozzi, Carolyn R, Fleiszig, Suzanne M J

“…Microbial communities are important for the health of mucosal tissues. Traditional culture and gene sequencing have demonstrated bacterial populations on the…”
Get full text

Correction: Mucosal fluid glycoprotein DMBT1 suppresses twitching motility and virulence of the opportunistic pathogen Pseudomonas aeruginosa by Li, Jianfang, Metruccio, Matteo M E, Smith, Benjamin E, Evans, David J, Fleiszig, Suzanne M J

“…[This corrects the article DOI: 10.1371/journal.ppat.1006392.]…”
Get full text

The importance of the Pseudomonas aeruginosa type III secretion system in epithelium traversal depends upon conditions of host susceptibility by Sullivan, Aaron B, Tam, K P Connie, Metruccio, Matteo M E, Evans, David J, Fleiszig, Suzanne M J

“…Pseudomonas aeruginosa is invasive or cytotoxic to host cells, depending on the type III secretion system (T3SS) effectors encoded. While the T3SS is known to…”
Get full text

Contact lens-related corneal infection: Intrinsic resistance and its compromise by Fleiszig, Suzanne M.J., Kroken, Abby R., Nieto, Vincent, Grosser, Melinda R., Wan, Stephanie J., Metruccio, Matteo M.E., Evans, David J.

“…Contact lenses represent a widely utilized form of vision correction with more than 140 million wearers worldwide. Although generally well-tolerated, contact…”
Get full text

TRPA1 and TPRV1 Ion Channels Are Required for Contact Lens-Induced Corneal Parainflammation and Can Modulate Levels of Resident Corneal Immune Cells by Datta, Ananya, Lee, Ji Hyun, Flandrin, Orneika, Horneman, Hart, Lee, Justin, Metruccio, Matteo M. E., Bautista, Diana, Evans, David J., Fleiszig, Suzanne M. J.

“…PurposeContact lens wear can induce corneal parainflammation involving CD11c+ cell responses (24 hours), γδ T cell responses (24 hours and 6 days), and…”
Get full text

DMBT1 inhibition of Pseudomonas aeruginosa twitching motility involves its N-glycosylation and cannot be conferred by the Scavenger Receptor Cysteine-Rich bacteria-binding peptide domain by Li, Jianfang, Wan, Stephanie J., Metruccio, Matteo M. E., Ma, Sophia, Nazmi, Kamran, Bikker, Floris J., Evans, David J., Fleiszig, Suzanne M. J.

“…The scavenging capacity of glycoprotein DMBT1 helps defend mucosal epithelia against microbes. DMBT1 binding to multiple bacterial species involves its…”
Get full text

Contributions of MyD88-dependent receptors and CD11c-positive cells to corneal epithelial barrier function against Pseudomonas aeruginosa by Metruccio, Matteo M. E., Tam, Connie, Evans, David J., Xie, Anna L., Stern, Michael E., Fleiszig, Suzanne M. J.

“…Previously we reported that corneal epithelial barrier function against Pseudomonas aeruginosa was MyD88-dependent. Here, we explored contributions of…”
Get full text

Pseudomonas aeruginosa Outer Membrane Vesicles Triggered by Human Mucosal Fluid and Lysozyme Can Prime Host Tissue Surfaces for Bacterial Adhesion by Metruccio, Matteo M E, Evans, David J, Gabriel, Manal M, Kadurugamuwa, Jagath L, Fleiszig, Suzanne M J

“…Pseudomonas aeruginosa is a leading cause of human morbidity and mortality that often targets epithelial surfaces. Host immunocompromise, or the presence of…”
Get full text

A novel murine model for contact lens wear reveals clandestine IL-1R dependent corneal parainflammation and susceptibility to microbial keratitis upon inoculation with Pseudomonas aeruginosa by Metruccio, Matteo M.E., Wan, Stephanie J., Horneman, Hart, Kroken, Abby R., Sullivan, Aaron B., Truong, Tan N., Mun, James J., Tam, Connie K.P., Frith, Robin, Welsh, Laurence, George, Melanie D., Morris, Carol A., Evans, David J., Fleiszig, Suzanne M.J.

“…Contact lens wear carries a risk of complications, including corneal infection. Solving these complications has been hindered by limitations of existing animal…”
Get full text

Human tear fluid modulates the Pseudomonas aeruginosa transcriptome to alter antibiotic susceptibility by Tabor, Lauren M., Grosser, Melinda R., Metruccio, Matteo M.M.E., Kumar, Naren G., Wu, Yvonne T., Nieto, Vincent, Evans, David J., Fleiszig, Suzanne M.J.

“…Previously, we showed that tear fluid protects corneal epithelial cells against Pseudomonas aeruginosa without suppressing bacterial viability. Here, we…”
Get full text

Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation: Host cell tropism of P. acnes by Mak, Tim N., Fischer, Natalie, Laube, Britta, Brinkmann, Volker, Metruccio, Matteo M. E., Sfanos, Karen S., Mollenkopf, Hans-Joachim, Meyer, Thomas F., Brüggemann, Holger

Get full text