Search Results - "Metri, Prashant K"

Development of 1-(4-(Substituted)piperazin-1-yl)-2-((2-((4-methoxybenzyl)thio)pyrimidin-4-yl)oxy)ethanones That Target Poly (ADP-Ribose) Polymerase in Human Breast Cancer Cells by Deveshegowda, Suresha N, Metri, Prashant K, Shivakumar, Rashmi, Yang, Ji-Rui, Rangappa, Shobith, Swamynayaka, Ananda, Shanmugam, Muthu K, Nagaraja, Omantheswara, Madegowda, Mahendra, Babu Shubha, Priya, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Pandey, Vijay, Ahn, Kwang Seok, Lobie, Peter E, Basappa, Basappa

“…A number of uracil amides cleave poly (ADP-ribose) polymerase and therefore novel thiouracil amide compounds were synthesized and screened for the loss of cell…”
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Novel 1,3,4-oxadiazole Targets STAT3 Signaling to Induce Antitumor Effect in Lung Cancer by Malojirao, Vikas H, Girimanchanaika, Swamy S, Shanmugam, Muthu K, Sherapura, Ankith, Dukanya, Metri, Prashant K, Vigneshwaran, Vellingiri, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Rangappa, Shobith, Mohan, Chakrabhavi Dhananjaya, Basappa, Prabhakar, Bettadathunga T, Rangappa, Kanchugarakoppal S

“…Lung cancer is the leading type of malignancy in terms of occurrence and mortality in the global context. STAT3 is an oncogenic transcription factor that is…”
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Anti-proliferative activity and characterization data on oxadiazole derivatives by Dukanya, Shanmugam, Muthu K, Rangappa, Shobith, Metri, Prashant K, Mohan, Surender, Basappa, Rangappa, Kanchugarakoppal S

“…This data in brief article explains the anti-cancer activity and characterization of oxadiazoles [1]. The main objective of this article was to provide general…”
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Enantiospecific formal total synthesis of (+)-dihydrokawain-5-ol by Metri, Prashant K.

“…Formal total synthesis of dihydrokawain-5-ol is accomplished starting from tartaric acid. Key reactions include Horner-Wadsworth-Emmons olefination, sodium…”
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Distinct chemical structures inhibit the CEMIP hyaluronidase and promote oligodendrocyte progenitor cell maturation by Peters, Alec, Banine, Fatima, Yasuhara, Kanon, Hoffman, Angela, Basappa, Metri, Prashant K., Gunning, Lily, Huffman, Ava, VanCampen, Jake, Shock, Clinton C., Back, Stephen A., Sherman, Larry S.

“…Growing evidence supports pathogenic roles for chronically elevated hyaluronidase activity in numerous conditions. Elevated expression of one such…”
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Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells by Dukanya, Shanmugam, Muthu K., Rangappa, Shobith, Metri, Prashant K., Mohan, Surender, Basappa, Rangappa, Kanchugarakoppal S.

“…[Display omitted] A novel series of indazole tethered oxadiazoles (OTDs) derivatives were synthesized, characterized and screened for their anti-proliferative…”
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Development of Novel Pyridine and Pyrimidine Clubbed Bisindoles as Inhibitors of AKT Pathway by Poonacha, Lisha K., Metri, Prashant K, Xi, Zhang, Ravish, Akshay, Nagaraja, Omantheswara, Kumar, Arun M., Parameshwaraiah, Sindhu M., Swamy Shivananju, Nanjunda, Madegowda, Mahendra, Lobie, Peter E., Babu Shubha, Priya, Pandey, Vijay, Basappa, Basappa

“…Indoles and their derivatives have long been studied for their anticancer properties. Breast cancer has been treated using indole‐3‐carbinol, Indirubins, and…”
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Enantiospecific Total Synthesis of (−)-Bengamide E by Metri, Prashant K., Schiess, Raphael, Prasad, Kavirayani R.

“…Total synthesis of the polyhydroxy caprolactam amide natural product, bengamide E, is accomplished starting from tartaric acid. Key reactions in the synthesis…”
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Development of Novel Indole and Coumarin Derivatives as Antibacterial Agents That Target Histidine Kinase in S. aureus by Poonacha, Lisha K., Ramesh, Rashmi, Ravish, Akshay, Mohan, Arunkumar, Uppar, Pradeep M., Metri, Prashant K., Shivananju, Nanjunda Swamy, Gaonkar, Santosh L., Gopal, Shubha, Sukhorukov, Alexey Yu, Pandey, Vijay, Shubha, Priya Babu, Basappa, Basappa

“…Heterocyclic compounds can specifically regulate bacterial development by targeting specific bacterial enzymes and metabolic pathways. The ESKAPE pathogens are…”
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MPK-09, a Small Molecule Inspired from Bioactive Styryllactone Restores the Wild-Type Function of Mutant p53 by Metri, Prashant K, Naz, Sarwat, Kondaiah, Paturu, Prasad, Kavirayani R

“…In the search for more efficacious and less toxic cancer drugs, the tumor suppressor p53 protein has long been a desirable therapeutic target. In the recent…”
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Enantiospecific Total Synthesis of (-)-BengamideE by Metri, Prashant K, Schiess, Raphael, Prasad, Kavirayani R

“…Total synthesis of the polyhydroxy caprolactam amide natural product, bengamide E, is accomplished starting from tartaric acid. Key reactions in the synthesis…”
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