Search Results - "Metref, Salima"
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Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy
Published in Proceedings of the National Academy of Sciences - PNAS (08-09-2009)“…Elevated plasma urate levels are associated with metabolic, cardiovascular, and renal diseases. Urate may also form crystals, which can be deposited in joints…”
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2
Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice
Published in American journal of physiology. Renal physiology (01-09-2013)“…Plasma urate levels are higher in humans than rodents (240-360 vs. ∼30 μM) because humans lack the liver enzyme uricase. High uricemia in humans may protect…”
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3
Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation
Published in Diabetes (New York, N.Y.) (01-11-2020)“…The ventromedial nucleus of the hypothalamus (VMN) is involved in the counterregulatory response to hypoglycemia. VMN neurons activated by hypoglycemia…”
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4
Fgf15 neurons of the dorsomedial hypothalamus control glucagon secretion and hepatic gluconeogenesis
Published in Diabetes (New York, N.Y.) (01-07-2021)“…The counterregulatory response to hypoglycemia is an essential survival function. It is controlled by an integrated network of glucose responsive neurons,…”
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Nervous glucose sensing regulates postnatal [Beta] cell proliferation and glucose homeostasis
Published in The Journal of clinical investigation (02-01-2014)“…How glucose sensing by the nervous system impacts the regulation of β cell mass and function during postnatal development and throughout adulthood is…”
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6
Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis
Published in The Journal of clinical investigation (01-01-2014)“…How glucose sensing by the nervous system impacts the regulation of β cell mass and function during postnatal development and throughout adulthood is…”
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7
Hepatic glucose sensing is required to preserve β cell glucose competence
Published in The Journal of clinical investigation (01-04-2013)“…Liver glucose metabolism plays a central role in glucose homeostasis and may also regulate feeding and energy expenditure. Here we assessed the impact of…”
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8
No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse
Published in Kidney international (01-05-2015)“…Urate is the metabolic end point of purines in humans. Although supra-physiological plasma urate levels are associated with obesity, insulin resistance,…”
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9
Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function
Published in Diabetes (New York, N.Y.) (01-12-2015)“…Insulin-like growth factor 2 (IGF2), produced and secreted by adult β-cells, functions as an autocrine activator of the β-cell insulin-like growth factor 1…”
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10
Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons
Published in The FASEB journal (01-06-2010)“…The physiological contribution of glucose in thermoregulation is not completely established nor whether this control may involve a regulation of the…”
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11
Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis
Published in The Journal of clinical investigation (01-01-2014)“…How glucose sensing by the nervous system impacts the regulation of β cell mass and function during post-natal development and throughout adulthood is…”
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Journal Article -
12
Autocrine Action of IGF2 Regulates Adult [Beta]-Cell Mass and Function
Published in Diabetes (New York, N.Y.) (01-12-2015)“…Insulin-like growth factor 2 (IGF2), produced and secreted by adult ...-cells, functions as an autocrine activator of the ...-cell insulin-like growth factor 1…”
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13
Hepatic glucose sensing is required to preserve [Beta] cell glucose competence
Published in The Journal of clinical investigation (01-04-2013)“…Liver glucose metabolism plays a central role in glucose homeostasis and may also regulate feeding and energy expenditure. Here we assessed the impact of…”
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Journal Article