Search Results - "Metodieva, Anna"

The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia by Rafiei, Anahita, Mian, Afsar Ali, Döring, Claudia, Metodieva, Anna, Oancea, Claudia, Thalheimer, Frederic B, Hansmann, Martin Leo, Ottmann, Oliver Gerhard, Ruthardt, Martin

“…The hallmark of Philadelphia chromosome positive (Ph(+)) leukemia is the BCR/ABL kinase, which is successfully targeted by selective ATP competitors. However,…”
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Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism by Khateb, Mamduh, Ruimi, Nili, Khamisie, Hazem, Najajreh, Yousef, Mian, Afsar, Metodieva, Anna, Ruthardt, Martin, Mahajna, Jamal

“…Philadelphia positive leukemias are characterized by the presence of Bcr-Abl fusion protein which exhibits an abnormal kinase activity. Selective Abl kinase…”
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Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I by Mian, Afsar Ali, Metodieva, Anna, Badura, Susanne, Khateb, Mamduh, Ruimi, Nili, Najajreh, Yousef, Ottmann, Oliver Gerhard, Mahajna, Jamal, Ruthardt, Martin

“…Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to…”
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p185BCR/ABL has a lower sensitivity than p210BCR/ABL to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia by MIAN, Afsar A, METODIEVA, Anna, NAJAJREH, Yousef, OTTMANN, Oliver G, MAHAJNA, Jamal, RUTHARDT, Martin

“…Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the…”
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The functional interplay between the t by Rafiei, Anahita, Mian, Afsar Ali, Doring, Claudia, Metodieva, Anna, Oancea, Claudia, Thalheimer, Frederic B, Hansmann, Martin Leo, Ottmann, Oliver Gerhard, Ruthardt, Martin

“…The hallmark of Philadelphia chromosome positive ([Ph.sup.+]) leukemia is the BCR/ABL kinase, which is successfully targeted by selective ATP competitors…”
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The Functional Interplay Between the t(9;22)-Associated Fusion Proteins BCR/ABL and ABL/BCR in Philadelphia Chromosome-Positive Acute Lymphatic Leukemia: e1005144 by Rafiei, Anahita, Mian, Afsar Ali, Döring, Claudia, Metodieva, Anna, Oancea, Claudia, Thalheimer, Frederic B, Hansmann, Martin Leo, Ottmann, Oliver Gerhard, Ruthardt, Martin

“…The hallmark of Philadelphia chromosome positive (Ph+) leukemia is the BCR/ABL kinase, which is successfully targeted by selective ATP competitors. However,…”
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Prominin-1/CD133 Is Involved in the Lineage Decision As Well As a in the Sensitivity to Molecular Therapy in Ph+ Acute Lymphatic Leukemia by Metodieva, Anna T., Pfeifer, Heike, Mian, Afsar, Vogel, Anja, Serve, Hubert, Ottmann, Oliver G., Ruthardt, Martin

“…Abstract 2579 Chronic myelogenous leukemia (CML) and Philadephia chromosome-positive acute lymphatic leukemia (Ph+ ALL) is caused by the t(9;22) which fuses…”
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Antiviral Effect of Oxoglaucine in Combination with Some Enterovirus Replication Inhibitors by Nikolaeva-Glomb, Lubomira, Stoyanova, Adelina, Metodieva, Anna, Galabov, Angel S.

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The Reciprocal t(9;22) p96ABL/BCR fusion Protein Eenhances the Transformation Potential of BCR/ABL and Increases Therapy Resistance in Models of Ph+ Acute Lymphatic Leukemia by Rafiei, Anahita, Mian, Afsar, Metodieva, Anna, Oancea, Claudia, Serve, Hubert, Pfeifer, Heike, Ottmann, Oliver G., Ruthardt, Martin

“…Abstract 3539 The t(9;22)(q34;q11) is a balanced translocation. The cytogenetic correlate of der22 is the so-called Philadelphia chromosome (Ph). Der22…”
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PF-114, a Novel Selective Pan BCR/ABL Inhibitor Targets The T315I and Suppress Models Of Advanced Ph+ ALL by Mian, Afsar, Rafiei, Anahita, Metodieva, Anna, Haberbosch, Isabella, Zeifman, Alexey, Titov, Ilya, Stroylov, Victor, Stroganov, Oleg, Novikov, Fedor, Ottmann, Oliver G., Chilov, Ghermes, Ruthardt, Martin

“…Targeting BCR/ABL by ABL-directed kinase inhibitors (AKIs) induces long lasting remissions in patients with chronic myeloid leukemia (CML), and short…”
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p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia by Mian, Afsar A, Metodieva, Anna, Najajreh, Yousef, Ottmann, Oliver G, Mahajna, Jamal, Ruthardt, Martin

“…The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia…”
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The Degree of Response of Philadelphia Chromosome Positive Acute Lymphatic Leukemia to Allosteric Inhibition by GNF-2 Depends on the Presence of Either p185-BCR/ABL or p210-BCR/ABL by Mian, Afsar, Metodieva, Anna, Najajreh, Yousef, Serve, Hubert, Ottmann, Oliver, Mahajna, Jamal, Ruthardt, Martin

“…Abstract 598 The t(9;22) translocation (Ph+) leads to the formation of the chimeric bcr/abl fusion gene, which encodes the BCR/ABL fusion protein. Depending on…”
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