Search Results - "Metcalf, Ginger A"

Truvari: refined structural variant comparison preserves allelic diversity by English, Adam C, Menon, Vipin K, Gibbs, Richard A, Metcalf, Ginger A, Sedlazeck, Fritz J

“…The fundamental challenge of multi-sample structural variant (SV) analysis such as merging and benchmarking is identifying when two SVs are the same. Common…”
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The gut mycobiome of the Human Microbiome Project healthy cohort by Nash, Andrea K, Auchtung, Thomas A, Wong, Matthew C, Smith, Daniel P, Gesell, Jonathan R, Ross, Matthew C, Stewart, Christopher J, Metcalf, Ginger A, Muzny, Donna M, Gibbs, Richard A, Ajami, Nadim J, Petrosino, Joseph F

“…Most studies describing the human gut microbiome in healthy and diseased states have emphasized the bacterial component, but the fungal microbiome (i.e., the…”
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Whole-genome sequencing as an investigational device for return of hereditary disease risk and pharmacogenomic results as part of the All of Us Research Program by Venner, Eric, Muzny, Donna, Smith, Joshua D, Walker, Kimberly, Neben, Cynthia L, Lockwood, Christina M, Empey, Phillip E, Metcalf, Ginger A, Kachulis, Chris, Mian, Sana, Musick, Anjene, Rehm, Heidi L, Harrison, Steven, Gabriel, Stacey, Gibbs, Richard A, Nickerson, Deborah, Zhou, Alicia Y, Doheny, Kimberly, Ozenberger, Bradley, Topper, Scott E, Lennon, Niall J

“…The All of Us Research Program (AoURP, "the program") is an initiative, sponsored by the National Institutes of Health (NIH), that aims to enroll one million…”
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Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study by de Vries, Paul S, Yu, Bing, Feofanova, Elena V, Metcalf, Ginger A, Brown, Michael R, Zeighami, Atefeh L, Liu, Xiaoming, Muzny, Donna M, Gibbs, Richard A, Boerwinkle, Eric, Morrison, Alanna C

“…Oligopeptides are important markers of protein metabolism, as they are cleaved from larger polypeptides and proteins. Genetic association studies may help…”
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Sequence-Based Analysis of Lipid-Related Metabolites in a Multiethnic Study by Feofanova, Elena V, Yu, Bing, Metcalf, Ginger A, Liu, Xiaoming, Muzny, Donna, Below, Jennifer E, Wagenknecht, Lynne E, Gibbs, Richard A, Morrison, Alanna C, Boerwinkle, Eric

“…Small molecule lipid-related metabolites are important components of fatty acid and steroid metabolism-two important contributors to human health. This study…”
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Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk by Behera, Sairam, Belyeu, Jonathan R, Chen, Xiao, Paulin, Luis F, Nguyen, Ngoc Quynh H, Newman, Emma, Mahmoud, Medhat, Menon, Vipin K, Qi, Qibin, Joshi, Parag, Marcovina, Santica, Rossi, Massimiliano, Roller, Eric, Han, James, Onuchic, Vitor, Avery, Christy L, Ballantyne, Christie M, Rodriguez, Carlos J, Kaplan, Robert C, Muzny, Donna M, Metcalf, Ginger A, Gibbs, Richard A, Yu, Bing, Boerwinkle, Eric, Eberle, Michael A, Sedlazeck, Fritz J

“…The abundance of Lp(a) protein holds significant implications for the risk of cardiovascular disease (CVD), which is directly impacted by the copy number (CN)…”
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Loss-of-function variants influence the human serum metabolome by Yu, Bing, Li, Alexander H, Metcalf, Ginger A, Muzny, Donna M, Morrison, Alanna C, White, Simon, Mosley, Thomas H, Gibbs, Richard A, Boerwinkle, Eric

“…The metabolome is a collection of small molecules resulting from multiple cellular and biological processes that can act as biomarkers of disease, and…”
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Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study by Smith, Hadley Stevens, Sanchez, Clarissa E., Maag, Ronald, Buentello, Alexandria, Murdock, David R., Metcalf, Ginger A., Hadley, Trevor D., Riconda, Daniel L., Boerwinkle, Eric, Wehrens, Xander H.T., Ballantyne, Christie M., Gibbs, Richard A., McGuire, Amy L., Pereira, Stacey

“…Routine genome-wide screening for cardiovascular disease risk may inform clinical decision-making. However, little is known about whether clinicians and…”
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Temporal development of the gut microbiome in early childhood from the TEDDY study by Stewart, Christopher J., Ajami, Nadim J., O’Brien, Jacqueline L., Hutchinson, Diane S., Smith, Daniel P., Wong, Matthew C., Ross, Matthew C., Lloyd, Richard E., Doddapaneni, HarshaVardhan, Metcalf, Ginger A., Muzny, Donna, Gibbs, Richard A., Vatanen, Tommi, Huttenhower, Curtis, Xavier, Ramnik J., Rewers, Marian, Hagopian, William, Toppari, Jorma, Ziegler, Anette-G., She, Jin-Xiong, Akolkar, Beena, Lernmark, Ake, Hyoty, Heikki, Vehik, Kendra, Krischer, Jeffrey P., Petrosino, Joseph F.

“…The development of the microbiome from infancy to childhood is dependent on a range of factors, with microbial–immune crosstalk during this time thought to be…”
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Unveiling microbial diversity: harnessing long-read sequencing technology by Agustinho, Daniel P., Fu, Yilei, Menon, Vipin K., Metcalf, Ginger A., Treangen, Todd J., Sedlazeck, Fritz J.

“…Long-read sequencing has recently transformed metagenomics, enhancing strain-level pathogen characterization, enabling accurate and complete…”
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Structure and function of the healthy pre-adolescent pediatric gut microbiome by Hollister, Emily B, Riehle, Kevin, Luna, Ruth Ann, Weidler, Erica M, Rubio-Gonzales, Michelle, Mistretta, Toni-Ann, Raza, Sabeen, Doddapaneni, Harsha V, Metcalf, Ginger A, Muzny, Donna M, Gibbs, Richard A, Petrosino, Joseph F, Shulman, Robert J, Versalovic, James

“…The gut microbiome influences myriad host functions, including nutrient acquisition, immune modulation, brain development, and behavior. Although human gut…”
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Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome by Hollister, Emily B., Oezguen, Numan, Chumpitazi, Bruno P., Luna, Ruth Ann, Weidler, Erica M., Rubio-Gonzales, Michelle, Dahdouli, Mahmoud, Cope, Julia L., Mistretta, Toni-Ann, Raza, Sabeen, Metcalf, Ginger A., Muzny, Donna M., Gibbs, Richard A., Petrosino, Joseph F., Heitkemper, Margaret, Savidge, Tor C., Shulman, Robert J., Versalovic, James

“…Accurate diagnosis and stratification of children with irritable bowel syndrome (IBS) remain challenging. Given the central role of recurrent abdominal pain in…”
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Whole-exome sequencing of 14 389 individuals from the ESP and CHARGE consortia identifies novel rare variation associated with hemostatic factors by Pankratz, Nathan, Wei, Peng, Brody, Jennifer A, Chen, Ming-Huei, de Vries, Paul S, Huffman, Jennifer E, Stimson, Mary Rachel, Auer, Paul L, Boerwinkle, Eric, Cushman, Mary, de Maat, Moniek P M, Folsom, Aaron R, Franco, Oscar H, Gibbs, Richard A, Haagenson, Kelly K, Hofman, Albert, Johnsen, Jill M, Kovar, Christie L, Kraaij, Robert, McKnight, Barbara, Metcalf, Ginger A, Muzny, Donna, Psaty, Bruce M, Tang, Weihong, Uitterlinden, André G, van Rooij, Jeroen G J, Dehghan, Abbas, O'Donnell, Christopher J, Reiner, Alex P, Morrison, Alanna C, Smith, Nicholas L

“…Abstract Plasma levels of fibrinogen, coagulation factors VII and VIII and von Willebrand factor (vWF) are four intermediate phenotypes that are heritable and…”
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Whole genome sequence analysis of serum amino acid levels by Yu, Bing, de Vries, Paul S, Metcalf, Ginger A, Wang, Zhe, Feofanova, Elena V, Liu, Xiaoming, Muzny, Donna Marie, Wagenknecht, Lynne E, Gibbs, Richard A, Morrison, Alanna C, Boerwinkle, Eric

“…Blood levels of amino acids are important biomarkers of disease and are influenced by synthesis, protein degradation, and gene-environment interactions. Whole…”
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Inter and intra-host diversity of RSV in hematopoietic stem cell transplant adults with normal and delayed viral clearance by Avadhanula, Vasanthi, Agustinho, Daniel Paiva, Menon, Vipin Kumar, Chemaly, Roy F, Shah, Dimpy P, Qin, Xiang, Surathu, Anil, Doddapaneni, Harshavardhan, Muzny, Donna M, Metcalf, Ginger A, Cregeen, Sara Javornik, Gibbs, Richard A, Petrosino, Joseph F, Sedlazeck, Fritz J, Piedra, Pedro A

“…Abstract Respiratory syncytial virus (RSV) infection in immunocompromised individuals often leads to prolonged illness, progression to severe lower respiratory…”
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Fully resolved assembly of Cryptosporidium parvum by Menon, Vipin K, Okhuysen, Pablo C, Chappell, Cynthia L, Mahmoud, Medhat, Mahmoud, Medhat, Meng, Qingchang, Doddapaneni, Harsha, Vee, Vanesa, Han, Yi, Salvi, Sejal, Bhamidipati, Sravya, Kottapalli, Kavya, Weissenberger, George, Shen, Hua, Ross, Matthew C, Hoffman, Kristi L, Cregeen, Sara Javornik, Muzny, Donna M, Metcalf, Ginger A, Gibbs, Richard A, Petrosino, Joseph F, Sedlazeck, Fritz J

“…Abstract Background Cryptosporidium parvum is an apicomplexan parasite commonly found across many host species with a global infection prevalence in human…”
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The Implementation Science for Genomic Health Translation (INSIGHT) Study in Epilepsy: Protocol for a Learning Health Care System by Feofanova, Elena Valeryevna, Zhang, Guo-Qiang, Lhatoo, Samden, Metcalf, Ginger A, Boerwinkle, Eric, Venner, Eric

“…Genomic medicine is poised to improve care for common complex diseases such as epilepsy, but additional clinical informatics and implementation science…”
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Rare Genetic Variants Associated With Sudden Cardiac Arrest in the Young: A Prospective, Population-Based Study by Holmstrom, Lauri, Chaudhary, Ninad S., Nakamura, Kotoka, Chugh, Harpriya, Uy-Evanado, Audrey, Norby, Faye, Metcalf, Ginger A., Menon, Vipin K., Yu, Bing, Boerwinkle, Eric, Chugh, Sumeet S., Akdemir, Zeynep, Kransdorf, Evan P.

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Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation by Eicher, John D, Chen, Ming-Huei, Pitsillides, Achilleas N, Lin, Honghuang, Veeraraghavan, Narayanan, Brody, Jennifer A, Metcalf, Ginger A, Muzny, Donna M, Gibbs, Richard A, Becker, Diane M, Becker, Lewis C, Faraday, Nauder, Mathias, Rasika A, Yanek, Lisa R, Boerwinkle, Eric, Cupples, L Adrienne, Johnson, Andrew D

“…Inhibition of platelet reactivity is a common therapeutic strategy in secondary prevention of cardiovascular disease. Genetic and environmental factors…”
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Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk by Yu, Bing, Pulit, Sara L, Hwang, Shih-Jen, Brody, Jennifer A, Amin, Najaf, Auer, Paul L, Bis, Joshua C, Boerwinkle, Eric, Burke, Gregory L, Chakravarti, Aravinda, Correa, Adolfo, Dreisbach, Albert W, Franco, Oscar H, Ehret, Georg B, Franceschini, Nora, Hofman, Albert, Lin, Dan-Yu, Metcalf, Ginger A, Musani, Solomon K, Muzny, Donna, Palmas, Walter, Raffel, Leslie, Reiner, Alex, Rice, Ken, Rotter, Jerome I, Veeraraghavan, Narayanan, Fox, Ervin, Guo, Xiuqing, North, Kari E, Gibbs, Richard A, van Duijn, Cornelia M, Psaty, Bruce M, Levy, Daniel, Newton-Cheh, Christopher, Morrison, Alanna C

“…BACKGROUND—Rare genetic variants influence blood pressure (BP). METHODS AND RESULTS—Whole-exome sequencing was performed on DNA samples from 17 956 individuals…”
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