Search Results - "Metanis, Norman"

The Thioredoxin System: A Promising Target for Cancer Drug Development by Ghareeb, Hiba, Metanis, Norman

“…The thioredoxin system is highly conserved system found in all living cells and comprises NADPH, thioredoxin, and thioredoxin reductase. This system plays a…”
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Selenium and Selenocysteine in Protein Chemistry by Mousa, Reem, Notis Dardashti, Rebecca, Metanis, Norman

“…Selenocysteine, the selenium‐containing analogue of cysteine, is the twenty‐first proteinogenic amino acid. Since its discovery almost fifty years ago, it has…”
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Copper‐Mediated Selenazolidine Deprotection Enables One‐Pot Chemical Synthesis of Challenging Proteins by Zhao, Zhenguang, Metanis, Norman

“…While chemical protein synthesis has granted access to challenging proteins, the synthesis of longer proteins is often limited by low abundance or…”
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Utilizing Copper-Mediated Deprotection of Selenazolidine for Cyclic Peptide Synthesis by Zhao, Zhenguang, Metanis, Norman

“…Selenazoliline (Sez) was originally developed as a masked form of selenocysteine (Sec) for the chemical synthesis of challenging proteins. Here, we utilize Sez…”
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Chemoselective Copper-Mediated Modification of Selenocysteines in Peptides and Proteins by Zhao, Zhenguang, Shimon, Daphna, Metanis, Norman

“…Highly valuable bioconjugated molecules must be synthesized through efficient, chemoselective chemical modifications of peptides and proteins. Herein, we…”
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Strategic Use of Non-Native Diselenide Bridges to Steer Oxidative Protein Folding by Metanis, Norman, Hilvert, Donald

“…Targeted insertion of a non‐native diselenide cross‐link into a cysteine‐rich protein can be exploited to direct the early stages of oxidative folding so as to…”
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One‐Pot Chemical Protein Synthesis Utilizing Fmoc‐Masked Selenazolidine to Address the Redox Functionality of Human Selenoprotein F by Zhao, Zhenguang, Mousa, Reem, Metanis, Norman

“…Human SELENOF is an endoplasmic reticulum (ER) selenoprotein that contains the redox active motif CXU (C is cysteine and U is selenocysteine), resembling the…”
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Harnessing selenocysteine reactivity for oxidative protein folding by Metanis, Norman, Hilvert, Donald

“…Although oxidative folding of disulfide-rich proteins is often sluggish, this process can be significantly enhanced by targeted replacement of cysteines with…”
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Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion by Longo, Liam M., Despotovic, Dragana, Weil-Ktorza, Orit, Walker, Matthew J., Jabłońska, Jagoda, Fridmann-Sirkis, Yael, Varani, Gabriele, Metanis, Norman, Tawfik, Dan S.

“…De novo emergence demands a transition from disordered polypeptides into structured proteins with well-defined functions. However, can polypeptides confer…”
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The Cys Sense: Thiol Redox Switches Mediate Life Cycles of Cellular Proteins by Radzinski, Meytal, Oppenheim, Tal, Metanis, Norman, Reichmann, Dana

“…Protein homeostasis is an essential component of proper cellular function; however, sustaining protein health is a challenging task, especially during the…”
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Selenolysine: A New Tool for Traceless Isopeptide Bond Formation by Dardashti, Rebecca Notis, Kumar, Shailesh, Sternisha, Shawn M., Reddy, Post Sai, Miller, Brian G., Metanis, Norman

“…Despite their biological importance, post‐translationally modified proteins are notoriously difficult to produce in a homogeneous fashion by using conventional…”
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Diselenide crosslinks for enhanced and simplified oxidative protein folding by Mousa, Reem, Hidmi, Taghreed, Pomyalov, Sergei, Lansky, Shifra, Khouri, Lareen, Shalev, Deborah E., Shoham, Gil, Metanis, Norman

“…The in vitro oxidative folding of proteins has been studied for over sixty years, providing critical insight into protein folding mechanisms. Hirudin, the most…”
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Copper‐Mediated Selenazolidine Deprotection Enables One‐Pot Chemical Synthesis of Challenging Proteins by Zhao, Zhenguang, Metanis, Norman

“…While chemical protein synthesis has granted access to challenging proteins, the synthesis of longer proteins is often limited by low abundance or…”
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Peptide and Protein Cysteine Modification Enabled by Hydrosulfuration of Ynamide by Wang, Changliu, Zhao, Zhenguang, Ghadir, Reem, Yang, Dechun, Zhang, Zhenjia, Ding, Zhe, Cao, Yuan, Li, Yuqing, Fassler, Rosi, Reichmann, Dana, Zhang, Yujie, Zhao, Yongli, Liu, Can, Bi, Xiaobao, Metanis, Norman, Zhao, Junfeng

“…Efficient functionalization of peptides and proteins has widespread applications in chemical biology and drug discovery. However, the chemoselective and…”
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Optimization of Statin-Loaded Delivery Nanoparticles for Treating Chronic Liver Diseases by Targeting Liver Sinusoidal Endothelial Cells by Gil, Mar, Khouri, Lareen, Raurell, Imma, Rafael, Diana, Andrade, Fernanda, Abasolo, Ibane, Schwartz, Jr, Simo, Martínez-Gómez, María, Salcedo, María Teresa, Pericàs, Juan Manuel, Hide, Diana, Wei, Mingxing, Metanis, Norman, Genescà, Joan, Martell, María

“…In this study, we developed functionalized polymeric micelles (FPMs) loaded with simvastatin (FPM-Sim) as a drug delivery system to target liver sinusoidal…”
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Organic solvent enhances oxidative folding of disulfide-rich proteins by Laps, Shay, Metanis, Norman

“…Natural protein folding takes place in aqueous cell environments. Now, it has been found that proteins in a water-free environment undergo faster and more…”
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Selenoglutathione-Mediated Rescue of Kinetically Trapped Intermediates in Oxidative Protein Folding by Metanis, Norman, Foletti, Carlotta, Beld , Joris, Hilvert, Donald

“…Selenoglutathione has been shown to have considerable potential as a catalyst of oxidative protein folding. Here we examine how this reagent modulates the…”
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Enhancing the gastrointestinal stability of salmon calcitonin through peptide stapling by Ghareeb, Hiba, Metanis, Norman

“…Salmon calcitonin (sCT) is a polypeptide hormone available in the clinic. sCT is degraded in the gastrointestinal tract in minutes. In this work, a stapled…”
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Natural and synthetic selenoproteins by Metanis, Norman, Hilvert, Donald

“…•Selenocysteine endows proteins with novel redox properties.•New recombinant and chemical methods are facilitating selenoprotein production.•Many natural…”
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Frontispiece: The Thioredoxin System: A Promising Target for Cancer Drug Development by Ghareeb, Hiba, Metanis, Norman

“…The thioredoxin system, composed of thioredoxin (TRX), thioredoxin reductase (TR), and NADPH, plays critical roles in many cellular functions. However, it is…”
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