Search Results - "Metabolic engineering communications"

Advances in the development and application of microbial consortia for metabolic engineering by Jawed, Kamran, Yazdani, Syed Shams, Koffas, Mattheos AG

“…Recent advances in metabolic engineering enable the production of high-value chemicals via expressing complex biosynthetic pathways in a single microbial host…”
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Modular engineering for microbial production of carotenoids by Li, Cheng, Swofford, Charles A., Sinskey, Anthony J.

“…There is an increasing demand for carotenoids due to their applications in the food, flavor, pharmaceutical and feed industries, however, the extraction and…”
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CRISPR-Cas12a/Cpf1-assisted precise, efficient and multiplexed genome-editing in Yarrowia lipolytica by Yang, Zhiliang, Edwards, Harley, Xu, Peng

“…CRISPR-Cas9 has been widely adopted as the basic toolkit for precise genome-editing and engineering in various organisms. Alternative to Cas9, Cas12 or Cpf1…”
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Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity by Johnson, Christopher W., Salvachúa, Davinia, Khanna, Payal, Smith, Holly, Peterson, Darren J., Beckham, Gregg T.

“…The conversion of biomass-derived sugars and aromatic molecules to cis,cis-muconic acid (referred to hereafter as muconic acid or muconate) has been of recent…”
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Adaptive laboratory evolution of Pseudomonas putida KT2440 improves p-coumaric and ferulic acid catabolism and tolerance by Mohamed, Elsayed T., Werner, Allison Z., Salvachúa, Davinia, Singer, Christine A., Szostkiewicz, Kiki, Rafael Jiménez-Díaz, Manuel, Eng, Thomas, Radi, Mohammad S., Simmons, Blake A., Mukhopadhyay, Aindrila, Herrgård, Markus J., Singer, Steven W., Beckham, Gregg T., Feist, Adam M.

“…Pseudomonas putida KT2440 is a promising bacterial chassis for the conversion of lignin-derived aromatic compound mixtures to biofuels and bioproducts. Despite…”
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Systems biology approaches integrated with artificial intelligence for optimized metabolic engineering by Helmy, Mohamed, Smith, Derek, Selvarajoo, Kumar

“…Metabolic engineering aims to maximize the production of bio-economically important substances (compounds, enzymes, or other proteins) through the optimization…”
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Debottlenecking mevalonate pathway for antimalarial drug precursor amorphadiene biosynthesis in Yarrowia lipolytica by Marsafari, Monireh, Xu, Peng

“…World Health Organization reports that half of the population in developing countries are at risk of malaria infection. Artemisinin, the most potent…”
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Enhanced limonene production in a fast-growing cyanobacterium through combinatorial metabolic engineering by Lin, Po-Cheng, Zhang, Fuzhong, Pakrasi, Himadri B.

“…Terpenoids are a large and diverse group of natural products with commercial applications. Microbial production of terpenes is considered as a feasible…”
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YaliBricks, a versatile genetic toolkit for streamlined and rapid pathway engineering in Yarrowia lipolytica by Wong, Lynn, Engel, Jake, Jin, Erqing, Holdridge, Benjamin, Xu, Peng

“…Effective metabolic engineering of microorganisms relies on balanced expression of both heterologous and endogenous genes to channel metabolic flux towards…”
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Synthetic control of plasmid replication enables target- and self-curing of vectors and expedites genome engineering of Pseudomonas putida by Volke, Daniel C., Friis, Laura, Wirth, Nicolas T., Turlin, Justine, Nikel, Pablo I.

“…Genome engineering of non-conventional microorganisms calls for the development of dedicated synthetic biology tools. Pseudomonas putida is a Gram-negative,…”
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Metabolic engineering of an acid-tolerant yeast strain Pichia kudriavzevii for itaconic acid production by Sun, Wan, Vila-Santa, Ana, Liu, Na, Prozorov, Tanya, Xie, Dongming, Faria, Nuno Torres, Ferreira, Frederico Castelo, Mira, Nuno Pereira, Shao, Zengyi

“…Itaconic acid (IA), or 2-methylenesuccinic acid, has a broad spectrum of applications in the biopolymer industry owing to the presence of one vinyl bond and…”
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Development of both type I–B and type II CRISPR/Cas genome editing systems in the cellulolytic bacterium Clostridium thermocellum by Walker, Julie E., Lanahan, Anthony A., Zheng, Tianyong, Toruno, Camilo, Lynd, Lee R., Cameron, Jeffrey C., Olson, Daniel G., Eckert, Carrie A.

“…The robust lignocellulose-solubilizing activity of C. thermocellum makes it a top candidate for consolidated bioprocessing for biofuel production. Genetic…”
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Development of a high efficiency integration system and promoter library for rapid modification of Pseudomonas putida KT2440 by Elmore, Joshua R., Furches, Anna, Wolff, Gara N., Gorday, Kent, Guss, Adam M.

“…Pseudomonas putida strains are highly robust bacteria known for their ability to efficiently utilize a variety of carbon sources, including aliphatic and…”
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Metabolic engineering of Synechocystis sp. PCC 6803 for improved bisabolene production by Rodrigues, João S., Lindberg, Pia

“…[Display omitted] Terpenoids are a wide class of organic compounds with industrial relevance. The natural ability of cyanobacteria to produce terpenoids via…”
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Eliminating a global regulator of carbon catabolite repression enhances the conversion of aromatic lignin monomers to muconate in Pseudomonas putida KT2440 by Johnson, Christopher W., Abraham, Paul E., Linger, Jeffrey G., Khanna, Payal, Hettich, Robert L., Beckham, Gregg T.

“…Carbon catabolite repression refers to the preference of microbes to metabolize certain growth substrates over others in response to a variety of regulatory…”
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Harnessing the potential of artificial neural networks for predicting protein glycosylation by Kotidis, Pavlos, Kontoravdi, Cleo

“…Kinetic models offer incomparable insight on cellular mechanisms controlling protein glycosylation. However, their ability to reproduce site-specific glycoform…”
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A comprehensive genome-scale model for Rhodosporidium toruloides IFO0880 accounting for functional genomics and phenotypic data by Dinh, Hoang V., Suthers, Patrick F., Chan, Siu Hung Joshua, Shen, Yihui, Xiao, Tianxia, Deewan, Anshu, Jagtap, Sujit S., Zhao, Huimin, Rao, Christopher V., Rabinowitz, Joshua D., Maranas, Costas D.

“…Rhodosporidium toruloides is a red, basidiomycetes yeast that can accumulate a large amount of lipids and produce carotenoids. To better assess this non-model…”
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Improving the homologous recombination efficiency of Yarrowia lipolytica by grafting heterologous component from Saccharomyces cerevisiae by Ji, Qingchun, Mai, Jie, Ding, Ying, Wei, Yongjun, Ledesma-Amaro, Rodrigo, Ji, Xiao-Jun

“…The oleaginous non-conventional yeast Yarrowia lipolytica has enormous potential as a microbial platform for the synthesis of various bioproducts. However,…”
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Application of metabolic engineering to enhance the content of alkaloids in medicinal plants by Mora-Vásquez, Soledad, Wells-Abascal, Guillermo Gael, Espinosa-Leal, Claudia, Cardineau, Guy A., García-Lara, Silverio

“…Plants are a rich source of bioactive compounds, many of which have been exploited for cosmetic, nutritional, and medicinal purposes. Through the…”
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Improving protein solubility and activity by introducing small peptide tags designed with machine learning models by Han, Xi, Ning, Wenbo, Ma, Xiaoqiang, Wang, Xiaonan, Zhou, Kang

“…Improving catalytic ability of enzymes is critical to the success of many metabolic engineering projects, but the search space of possible protein mutants is…”
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