Search Results - "Messori, Luigi"

NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry by Alessio, Enzo, Messori, Luigi

“…NAMI-A ((ImH)[ -RuCl (dmso-S)(Im)], Im = imidazole) and KP1019/1339 (KP1019 = (IndH)[ -RuCl (Ind) ], Ind = indazole; KP1339 = Na[ -RuCl (Ind) ]) are two…”
Get full text

Molecular mechanisms and proposed targets for selected anticancer gold compounds by Casini, Angela, Messori, Luigi

“…Nowadays, gold compounds constitute a family of very promising experimental agents for cancer treatment. Indeed, several gold(I) and gold(III) compounds were…”
Get more information

Cisplatin binding to human serum albumin: a structural study by Ferraro, Giarita, Massai, Lara, Messori, Luigi, Merlino, Antonello

“…The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were…”
Get more information

Cisplatin Binding to Proteins: Molecular Structure of the Ribonuclease A Adduct by Messori, Luigi, Merlino, Antonello

“…The crystal structure of the main adduct formed in the reaction between cisplatin and bovine pancreatic ribonuclease is reported here. Notably, in both of the…”
Get full text

Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives by Navarro, Maribel, Gabbiani, Chiara, Messori, Luigi, Gambino, Dinorah

“…Tropical diseases today constitute a major health problem and a big challenge for drug discovery. Because of the limited arsenal of effective antiparasitic…”
Get full text

Protein Metalation by Medicinal Gold Compounds: Identification of the Main Features of the Metalation Process through ESI MS Experiments by Geri, Andrea, Massai, Lara, Messori, Luigi

“…Gold compounds form a new class of promising anticancer agents with innovative modes of action. It is generally believed that anticancer gold compounds, at…”
Get full text

Ruthenium metalation of proteins: the X-ray structure of the complex formed between NAMI-A and hen egg white lysozyme by Messori, Luigi, Merlino, Antonello

“…A crystallographic study of the adduct formed between hen egg white lysozyme (HEWL) and NAMI-A, an established ruthenium(III) anticancer agent in clinical…”
Get more information

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs by Bindoli, Alberto, Rigobello, Maria Pia, Scutari, Guido, Gabbiani, Chiara, Casini, Angela, Messori, Luigi

“…The thioredoxin system plays a key role in regulating the overall intracellular redox balance. It basically comprises the small redox protein thioredoxin…”
Get full text

Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies by Nobili, Stefania, Mini, Enrico, Landini, Ida, Gabbiani, Chiara, Casini, Angela, Messori, Luigi

“…Gold compounds are a class of metallodrugs with great potential for cancer treatment. During the last two decades, a large variety of gold(I) and gold(III)…”
Get full text

Cisplatin encapsulation within a ferritin nanocage: a high-resolution crystallographic study by Pontillo, Nicola, Pane, Francesca, Messori, Luigi, Amoresano, Angela, Merlino, Antonello

“…Cisplatin (CDDP) can be encapsulated within the central cavity of reconstituted (apo)ferritin, (A)Ft, to form a drug-loaded protein of potential great interest…”
Get more information

Iridium(I) Compounds as Prospective Anticancer Agents: Solution Chemistry, Antiproliferative Profiles and Protein Interactions for a Series of Iridium(I) N-Heterocyclic Carbene Complexes by Gothe, Yvonne, Marzo, Tiziano, Messori, Luigi, Metzler-Nolte, Nils

“…A series of structurally related mono‐ and bis‐NHC–iridium(I) (NHC: N‐heterocyclic carbene) complexes have been investigated for their suitability as potential…”
Get full text

Enlarging the scenario of site directed 19F labeling for NMR spectroscopy of biomolecules by Vitali, Valentina, Torricella, Francesco, Massai, Lara, Messori, Luigi, Banci, Lucia

“…The possibility of using selectively incorporated 19 F nuclei for NMR spectroscopic studies has retrieved increasing interest in recent years. The high…”
Get full text

Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation by Bazzicalupi, Carla, Ferraroni, Marta, Papi, Francesco, Massai, Lara, Bertrand, Benoît, Messori, Luigi, Gratteri, Paola, Casini, Angela

“…The dicarbene gold(I) complex [Au(9‐methylcaffein‐8‐ylidene)2]BF4 is an exceptional organometallic compound of profound interest as a prospective anticancer…”
Get full text

Reactions of Medicinal Gold(III) Compounds With Proteins and Peptides Explored by Electrospray Ionization Mass Spectrometry and Complementary Biophysical Methods by Massai, Lara, Zoppi, Carlotta, Cirri, Damiano, Pratesi, Alessandro, Messori, Luigi

“…Electrospray ionization mass spectrometry (ESI MS) is a powerful investigative tool to analyze the reactions of metallodrugs with proteins and peptides and…”
Get full text

Platinum-based Anticancer Drugs: Unveiling Novel Mechanisms of Action of Conventional Metallodrugs for Improved Therapies by Marzo, Tiziano, Messori, Luigi, La Mendola, Diego

Get more information

Direct detection of iron clusters in L ferritins through ESI-MS experiments by Massai, Lara, Ciambellotti, Silvia, Cosottini, Lucrezia, Messori, Luigi, Turano, Paola, Pratesi, Alessandro

“…Human cytoplasmic ferritins are heteropolymers of H and L subunits containing a catalytic ferroxidase center and a nucleation site for iron biomineralization,…”
Get more information

Chemical Modification of Auranofin Yields a New Family of Anticancer Drug Candidates: The Gold(I) Phosphite Analogues by Cirri, Damiano, Geri, Andrea, Massai, Lara, Mannelli, Michele, Gamberi, Tania, Magherini, Francesca, Becatti, Matteo, Gabbiani, Chiara, Pratesi, Alessandro, Messori, Luigi

“…A panel of four novel gold(I) complexes, inspired by the clinically established gold drug auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine…”
Get full text

Metal Ion Physiopathology in Neurodegenerative Disorders by Bolognin, Silvia, Messori, Luigi, Zatta, Paolo

“…Metal dyshomeostasis in the brain (BMD) has often been proposed as a possible cause for several neurodegenerative disorders (NDs). Nevertheless, the precise…”
Get full text

Arsenoplatin‑1 Is a Dual Pharmacophore Anticancer Agent by Miodragović, Đenana, Merlino, Antonello, Swindell, Elden P, Bogachkov, Abraham, Ahn, Richard W, Abuhadba, Sara, Ferraro, Giarita, Marzo, Tiziano, Mazar, Andrew P, Messori, Luigi, O’Halloran, Thomas V

“…Arsenoplatins are adducts of two chemically important anticancer drugs, cisplatin and arsenic trioxide, that have a Pt­(II) bond to an As­(III) hydroxide…”
Get full text

Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles by Menconi, Alessio, Marzo, Tiziano, Massai, Lara, Pratesi, Alessandro, Severi, Mirko, Petroni, Giulia, Antonuzzo, Lorenzo, Messori, Luigi, Pillozzi, Serena, Cirri, Damiano

“…Chloro(triethylphosphine)gold(I), (Et 3 PAuCl hereafter), is an Auranofin (AF)-related compound showing very similar biological and pharmacological properties…”
Get full text