Search Results - "Messing, Robert O"

A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety by Pomrenze, Matthew B, Tovar-Diaz, Jorge, Blasio, Angelo, Maiya, Rajani, Giovanetti, Simone M, Lei, Kelly, Morikawa, Hitoshi, Hopf, F Woodward, Messing, Robert O

“…The central amygdala (CeA) is important for fear responses to discrete cues. Recent findings indicate that the CeA also contributes to states of sustained…”
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Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake by Seif, Taban, Chang, Shao-Ju, Simms, Jeffrey A, Gibb, Stuart L, Dadgar, Jahan, Chen, Billy T, Harvey, Brandon K, Ron, Dorit, Messing, Robert O, Bonci, Antonello, Hopf, F Woodward

“…The authors show that optogenetic inhibition of inputs from medial prefrontal cortex (mPFC) or insula to the nucleus accumbens core (NAcore) inhibits…”
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Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats by de Guglielmo, Giordano, Kallupi, Marsida, Pomrenze, Matthew B., Crawford, Elena, Simpson, Sierra, Schweitzer, Paul, Koob, George F., Messing, Robert O., George, Olivier

“…The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during alcohol withdrawal has been hypothesized to induce high levels of…”
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Abstinence-dependent dissociable central amygdala microcircuits control drug craving by Venniro, Marco, Russell, Trinity I., Ramsey, Leslie A., Richie, Christopher T., Lesscher, Heidi M. B., Giovanetti, Simone M., Messing, Robert O., Shaham, Yavin

“…We recently reported that social choice-induced voluntary abstinence prevents incubation of methamphetamine craving in rats. This inhibitory effect was…”
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Prkcz null mice show normal learning and memory by Lee, Anna M., Kanter, Benjamin R., Wang, Dan, Lim, Jana P., Zou, Mimi E., Qiu, Chichen, McMahon, Thomas, Dadgar, Jahan, Fischbach-Weiss, Sarah C., Messing, Robert O.

“…Genetically removing PKM-ζ in mice has no effect on memory, and despite absence of this kinase, the original peptide inhibitor of PKM-ζ still disrupts memory…”
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Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning by Pomrenze, Matthew B., Giovanetti, Simone M., Maiya, Rajani, Gordon, Adam G., Kreeger, Lauren J., Messing, Robert O.

“…Central amygdala (CeA) neurons that produce corticotropin-releasing factor (CRF) regulate anxiety and fear learning. These CeACRF neurons release GABA and…”
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Blood and brain gene expression signatures of chronic intermittent ethanol consumption in mice by Ferguson, Laura B, Roberts, Amanda J, Mayfield, R Dayne, Messing, Robert O

“…Alcohol Use Disorder (AUD) is a chronic, relapsing syndrome diagnosed by a heterogeneous set of behavioral signs and symptoms. There are no laboratory tests…”
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Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alcohol intake by Warden, Anna S., Azzam, Moatasem, DaCosta, Adriana, Mason, Sonia, Blednov, Yuri A., Messing, Robert O., Mayfield, R. Dayne, Harris, R. Adron

“…•Females have a delayed and prolonged proinflammatory response after poly(I:C).•Timecourse of cytokine activation regulated alcohol intake in both…”
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Cell-type specific changes in PKC-delta neurons of the central amygdala during alcohol withdrawal by Dilly, Geoffrey A., Kittleman, Cory W., Kerr, Tony M., Messing, Robert O., Mayfield, R. Dayne

“…The central amygdala (CeA) contains a diverse population of cells, including multiple subtypes of GABAergic neurons, along with glia and epithelial cells…”
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RNA biomarkers for alcohol use disorder by Ferguson, Laura B, Mayfield, R Dayne, Messing, Robert O

“…Alcohol use disorder (AUD) is highly prevalent and one of the leading causes of disability in the US and around the world. There are some molecular biomarkers…”
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A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits by Pomrenze, Matthew B, Millan, E Zayra, Hopf, F Woodward, Keiflin, Ronald, Maiya, Rajani, Blasio, Angelo, Dadgar, Jahan, Kharazia, Viktor, De Guglielmo, Giordano, Crawford, Elena, Janak, Patricia H, George, Olivier, Rice, Kenner C, Messing, Robert O

“…Corticotrophin-releasing factor (CRF) is a 41 amino acid neuropeptide that coordinates adaptive responses to stress. CRF projections from neurons in the…”
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A neural substrate of compulsive alcohol use by Domi, Esi, Xu, Li, Toivainen, Sanne, Nordeman, Anton, Gobbo, Francesco, Venniro, Marco, Shaham, Yavin, Messing, Robert O, Visser, Esther, van den Oever, Michel C, Holm, Lovisa, Barbier, Estelle, Augier, Eric, Heilig, Markus

“…Alcohol intake remains controlled in a majority of users but becomes "compulsive," i.e., continues despite adverse consequences, in a minority who develop…”
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Protein Kinases and Addiction by Lee, Anna M., Messing, Robert O.

“…Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that…”
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Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice by Blasio, Angelo, Wang, Jingyi, Wang, Dan, Varodayan, Florence P., Pomrenze, Matthew B., Miller, Jacklyn, Lee, Anna M., McMahon, Thomas, Gyawali, Sandeep, Wang, Hua-Yu, Roberto, Marisa, McHardy, Stanton, Pleiss, Michael A., Messing, Robert O.

“…Despite the high cost and widespread prevalence of alcohol use disorders, treatment options are limited, underscoring the need for new, effective medications…”
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Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens by Lee, Anna M, Messing, Robert O

“…Nicotine addiction and alcohol use disorders are very widespread and often occur together. Currently, there is no single drug approved for the simultaneous…”
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Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cδ by Shanmugasundararaj, Sivananthaperumal, Das, Joydip, Sandberg, Warren S., Zhou, Xiaojuan, Wang, Dan, Messing, Robert O., Bruzik, Karol S., Stehle, Thilo, Miller, Keith W.

“…Elucidating the principles governing anesthetic-protein interactions requires structural determinations at high resolutions not yet achieved with ion channels…”
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Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils by Liu, Jialing, Solway, Karen, Messing, Robert O, Sharp, Frank R

“…Neurogenesis in the dentate gyrus of adult rodents is regulated by NMDA receptors, adrenal steroids, environmental stimuli, and seizures. To determine whether…”
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Protein kinase C isozymes and the regulation of diverse cell responses by Dempsey, E C, Newton, A C, Mochly-Rosen, D, Fields, A P, Reyland, M E, Insel, P A, Messing, R O

“…Individual protein kinase C (PKC) isozymes have been implicated in many cellular responses important in lung health and disease, including permeability,…”
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PKCε Increases Endothelin Converting Enzyme Activity and Reduces Amyloid Plaque Pathology in Transgenic Mice by Choi, Doo-Sup, Wang, Dan, Yu, Gui-Qui, Zhu, Guofen, Kharazia, Viktor N., Paredes, J. Peter, Chang, Wesley S., Deitchman, Jason K., Mucke, Lennart, Messing, Robert O.

“…Deposition of plaques containing amyloid P3 (AP3) peptides is a neuropathological hallmark of Alzheimer's disease (AD). Here we demonstrate that neuronal…”
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The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or Ent1-/- mouse erythrocytes by Endres, Christopher J, Moss, Aaron M, Ke, Ban, Govindarajan, Rajgopal, Choi, Doo-Sup, Messing, Robert O, Unadkat, Jashvant D

“…The polar nucleoside drug ribavirin is front-line treatment for chronic hepatitis C virus infection. The human equilibrative nucleoside transporter (ENT) 1…”
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