Search Results - "Messineo, Ludovico"

The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study by Azarbarzin, Ali, Sands, Scott A, Stone, Katie L, Taranto-Montemurro, Luigi, Messineo, Ludovico, Terrill, Philip I, Ancoli-Israel, Sonia, Ensrud, Kristine, Purcell, Shaun, White, David P, Redline, Susan, Wellman, Andrew

“…Abstract Aims Apnoea–hypopnoea index (AHI), the universal clinical metric of sleep apnoea severity, poorly predicts the adverse outcomes of sleep apnoea,…”
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The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial by Taranto-Montemurro, Luigi, Messineo, Ludovico, Sands, Scott A, Azarbarzin, Ali, Marques, Melania, Edwards, Bradley A, Eckert, Danny J, White, David P, Wellman, Andrew

“…There is currently no effective pharmacological treatment for obstructive sleep apnea (OSA). Recent investigations indicate that drugs with noradrenergic and…”
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Effects of the Combination of Atomoxetine and Oxybutynin on OSA Endotypic Traits by Taranto-Montemurro, Luigi, Messineo, Ludovico, Azarbarzin, Ali, Vena, Daniel, Hess, Lauren B., Calianese, Nicole A., White, David P., Wellman, Andrew, Sands, Scott A.

“…We recently showed that administration of the combination of the noradrenergic drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep…”
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Palatal prolapse as a signature of expiratory flow limitation and inspiratory palatal collapse in patients with obstructive sleep apnoea by Azarbarzin, Ali, Sands, Scott A, Marques, Melania, Genta, Pedro R, Taranto-Montemurro, Luigi, Messineo, Ludovico, White, David P, Wellman, Andrew

“…In some individuals with obstructive sleep apnoea (OSA), the palate prolapses into the velopharynx during expiration, limiting airflow through the nose or…”
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Predicting epiglottic collapse in patients with obstructive sleep apnoea by Azarbarzin, Ali, Marques, Melania, Sands, Scott A, Op de Beeck, Sara, Genta, Pedro R, Taranto-Montemurro, Luigi, de Melo, Camila M, Messineo, Ludovico, Vanderveken, Olivier M, White, David P, Wellman, Andrew

“…Obstructive sleep apnoea (OSA) is characterised by pharyngeal obstruction occurring at different sites. Endoscopic studies reveal that epiglottic collapse…”
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Breath-holding as a novel approach to risk stratification in COVID-19 by Messineo, Ludovico, Perger, Elisa, Corda, Luciano, Joosten, Simon A, Fanfulla, Francesco, Pedroni, Leonardo, Terrill, Philip I, Lombardi, Carolina, Wellman, Andrew, Hamilton, Garun S, Malhotra, Atul, Vailati, Guido, Parati, Gianfranco, Sands, Scott A

“…Despite considerable progress, it remains unclear why some patients admitted for COVID-19 develop adverse outcomes while others recover spontaneously. Clues…”
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Broadband Sound Administration Improves Sleep Onset Latency in Healthy Subjects in a Model of Transient Insomnia by Messineo, Ludovico, Taranto-Montemurro, Luigi, Sands, Scott A, Oliveira Marques, Melania D, Azabarzin, Ali, Wellman, David Andrew

“…Insomnia is a major public health problem in western countries. Previous small pilot studies showed that the administration of constant white noise can improve…”
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Hypnotics on Obstructive Sleep Apnea Severity and Endotypes: A Systematic Review and Meta-Analysis by Messineo, Ludovico, Sands, Scott A, Labarca, Gonzalo

“…Low arousal threshold and poor muscle responsiveness are common determinants of obstructive sleep apnea (OSA). Hypnotics were hypothesized as an alternative…”
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Mechanisms relating to sleeping position to the endotypes of sleep disordered breathing by Messineo, Ludovico, Joosten, Simon, Perger, Elisa

“…Obstructive sleep apnea (OSA) severity varies considerably depending on the body position during sleep in certain subjects. Such variability may be underpinned…”
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The combination of atomoxetine and dronabinol for the treatment of obstructive sleep apnea: a dose-escalating, open-label trial by Messineo, Ludovico, Norman, Daniel, Ojile, Joseph

“…The potential sedative effect of dronabinol and the high expression of cannabinoid receptors on the hypoglossal motor nuclei makes this agent a good candidate…”
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Targeting Endotypic Traits with Medications for the Pharmacological Treatment of Obstructive Sleep Apnea. A Review of the Current Literature by Taranto-Montemurro, Luigi, Messineo, Ludovico, Wellman, Andrew

“…Obstructive sleep apnea (OSA) is a highly prevalent condition with few therapeutic options. To date there is no approved pharmacotherapy for this disorder, but…”
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Circuit-dependent carbon dioxide rebreathing during continuous positive airway pressure by Messineo, Ludovico, Hete, Bernard, Diesem, Ryan, Noah, William

“…The current standard treatment for obstructive sleep apnea (OSA), continuous positive airway pressure (CPAP), is characterized by a low adherence rate due to…”
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The noradrenergic agent reboxetine plus the antimuscarinic hyoscine butylbromide reduces sleep apnoea severity: a double‐blind, placebo‐controlled, randomised crossover trial by Lim, Richard, Messineo, Ludovico, Grunstein, Ronald R., Carberry, Jayne C., Eckert, Danny J.

“…Key points Recent animal and human physiology studies indicate that noradrenergic and muscarinic processes are key mechanisms that mediate pharyngeal muscle…”
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Zolpidem increases sleep efficiency and the respiratory arousal threshold without changing sleep apnoea severity and pharyngeal muscle activity by Messineo, Ludovico, Eckert, Danny J., Lim, Richard, Chiang, Alan, Azarbarzin, Ali, Carter, Sophie G., Carberry, Jayne C.

“…Key points A decreased respiratory arousal threshold is one of the main contributors to obstructive sleep apnoea (OSA) pathogenesis. Several recent studies…”
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Obstructive sleep apnea and obesity: A review of epidemiology, pathophysiology and the effect of weight-loss treatments by Messineo, Ludovico, Bakker, Jessie P., Cronin, John, Yee, John, White, David P.

“…Despite the commonly-accepted paradigm that patients with obstructive sleep apnea (OSA) also invariably have obesity, OSA prevalence extends beyond obesity…”
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Corrigendum to “Kairos positive airway pressure (KPAP) equals continuous PAP in effectiveness, and offers superior comfort for obstructive sleep apnea treatment” [Sleep Med 124 (2024) 268–275/6239] by White, David P., Messineo, Ludovico, Thompson, Evelyn, Hughes, Bryan, Lannom, Wilson D., Hete, Bernard, Joshi, Abinash, Noah, William H.

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Ventilatory Drive Withdrawal Rather Than Reduced Genioglossus Compensation as a Mechanism of Obstructive Sleep Apnea in REM Sleep by Messineo, Ludovico, Eckert, Danny J, Taranto-Montemurro, Luigi, Vena, Daniel, Azarbarzin, Ali, Hess, Lauren B, Calianese, Nicole, White, David P, Wellman, Andrew, Gell, Laura, Sands, Scott A

“…REM sleep is associated with reduced ventilation and greater obstructive sleep apnea (OSA) severity than non-REM (nREM) sleep for reasons that have not been…”
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Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness by Azarbarzin, Ali, Zinchuk, Andrey, Wellman, Andrew, Labarca, Gonzalo, Vena, Daniel, Gell, Laura, Messineo, Ludovico, White, David P, Gottlieb, Daniel J, Redline, Susan, Peker, Yüksel, Sands, Scott A

“…Randomized controlled trials of continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA) have not demonstrated protection…”
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Response by Taranto-Montemurro, Luigi, Messineo, Ludovico, Azarbarzin, Ali, Wellman, Andrew, Sands, Scott

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0547 Vil-tra by Aishah, Atqiya, Kim, Molly, Norman, Daniel, Ojile, Joseph, Gell, Laura, Pho, Huy, Taranto-Montemurro, Luigi, Vena, Dan, Azarbarzin, Ali, Esmaeili, Neda, Wellman, Andrew, Sands, Scott, Messineo, Ludovico

“…Abstract Introduction Obstructive sleep apnea (OSA) poses deleterious health consequences. Pharmacotherapy is a promising alternative to the current standard…”
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