Search Results - "Messina, Marinella"

NOX66 as Monotherapy, and in Combination With Carboplatin, in Patients With Refractory Solid Tumors: Phase Ia/b Study by Kiknavelidze, Koba, Shavdia, Mikheil, Chikhladze, Nana, Abshilava, Lia, Messina, Marinella, Mautner, Gisela, Kelly, Graham

“…•NOX66 contains idronoxil, formulated as a rectal suppository.•CEP-1 is the first study to assess NOX66 in patients with refractory solid tumors.•NOX66 was…”
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Medullary Thyroid Carcinoma: Long-Term Outcomes of Surgical Treatment by Abraham, Deepak T., Low, Tsu-Hui, Messina, Marinella, Jackson, Nicole, Gill, Anthony, Chou, Angela S., Delbridge, Leigh, Learoyd, Diana, Robinson, Bruce G., Sidhu, Stan, Sywak, Mark

“…Background Medullary thyroid carcinoma (MTC) accounts for 5 to 10% of all thyroid cancers but is responsible for a disproportionate number of deaths. Methods…”
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Technology Insight: gene therapy and its potential role in the treatment of medullary thyroid carcinoma by Messina, Marinella, Robinson, Bruce G

“…Metastatic medullary thyroid cancer (MTC) responds poorly to conventional treatments with chemotherapy and radiotherapy. Gene therapy--the transfer of genetic…”
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Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma by Payne, Cathy A, Maleki, Sanaz, Messina, Marinella, O'Sullivan, Maree G, Stone, Glenn, Hall, Nathan R, Parkinson, Jonathon F, Wheeler, Helen R, Cook, Raymond J, Biggs, Michael T, Little, Nicholas S, Teo, Charles, Robinson, Bruce G, McDonald, Kerrie L

“…Reduction in the mRNA and protein expression of lipocalin-like prostaglandin D 2 (PGD 2 ) synthase (PGDS), the main arachidonic acid metabolite produced in…”
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Variation of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma by Parkinson, Jonathon F., Wheeler, Helen R., Clarkson, Adele, McKenzie, Catriona A., Biggs, Michael T., Little, Nicholas S., Cook, Raymond J., Messina, Marinella, Robinson, Bruce G., McDonald, Kerrie L.

“…Methylation of the promoter region of the O 6 -methylguanine-DNA methyltransferase ( MGMT ) gene is known to be predictive of response to temozolomide…”
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Adenovirus-mediated tumor-specific combined gene therapy using Herpes simplex virus thymidine ganciclovir system and murine interleukin-12 induces effective antitumor activity against medullary thyroid carcinoma by Yamazaki, Masanori, Straus, Francis H, Messina, Marinella, Robinson, Bruce G, Takeda, Teiji, Hashizume, Kiyoshi, DeGroot, Leslie J

“…The present treatment of advanced and metastatic medullary thyroid carcinoma (MTC) is unsatisfactory. Tissue-specific cancer gene therapy is a novel…”
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Molecular Genetics of Thyroid Tumors and Surgical Decision‐making by Learoyd, Diana L., Messina, Marinella, Zedenius, Jan, Robinson, Bruce G.

“…The study of thyroid tumor genetics has great relevance to surgeons and facilitates understanding tumor pathogenesis, prediction of tumor behavior, and…”
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Stable DNA transformation of Toxoplasma gondii using phleomycin selection by Messina, M, Niesman, I, Mercier, C, Sibley, L D

“…Toxoplasma gondii (Tg) is an obligate intracellular protozoan parasite that is an important opportunistic pathogen in humans. To provide additional tools for…”
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Preclinical Evaluation of Bisantrene As Single Agent and in Combination with Decitabine for Acute Myeloid Leukemia by Verrills, Nicole M, Murray, Heather C, Brzozowski, Joshua S, Panicker, Nikita, Miller, Kasey, Messina, Marinella, Buckley, Benjamin J, Kelso, Michael J, Enjeti, Anoop K

“…Anthracyclines, particularly doxorubicin and idarubicin, together with cytarabine, have comprised standard of care induction chemotherapy in acute myeloid…”
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Phase I study of a novel S1P inhibitor, NOX66, in combination with radiotherapy in patients with metastatic castration-resistant prostate cancer by de Souza, Paul L., Capp, Anne Louise, Chikhladze, Nana, Mezvrishvili, Zaza, Messina, Marinella, Mautner, Gisela

“…Abstract only 5533 Background: NOX66 is a new formulation of the small molecule, idronoxil. The primary mechanism of action of idronoxil stems from its binding…”
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A phase 1 study of NOX66 in combination with carboplatin in patients with end stage solid tumours by de Souza, Paul L., Messina, Marinella, Minns, Ian, Shavdia, Mikheil, Chikhladze, Nana, Kelly, Graham

“…Abstract only…”
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Variation of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma by Parkinson, Jonathon F, Wheeler, Helen R, Clarkson, Adele, McKenzie, Catriona A, Biggs, Michael T, Little, Nicholas S, Cook, Raymond J, Messina, Marinella, Robinson, Bruce G, McDonald, Kerrie L

“…Methylation of the promoter region of the O ( 6 ) -methylguanine-DNA methyltransferase (MGMT) gene is known to be predictive of response to temozolomide…”
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Detection of the PAX8-PPARγ Fusion Oncogene in Both Follicular Thyroid Carcinomas and Adenomas by Cheung, Linda, Messina, Marinella, Gill, Anthony, Clarkson, Adele, Learoyd, Diana, Delbridge, Leigh, Wentworth, John, Philips, Jeanette, Clifton-Bligh, Roderick, Robinson, Bruce G.

“…Chromosomal translocations encoding fusion oncoproteins are common in hematological malignancies, sarcomas, and papillary thyroid carcinomas. A recent study of…”
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Medullary thyroid carcinoma presenting with an initial CEA elevation by Abraham, Deepak, Delbridge, Leigh, Clifton-Bligh, Roderick, Clifton-Bligh, Phillip, Grodski, Simon, Robinson, Bruce G., Messina, Marinella, Sidhu, Stan

“…Background:  Carcinoembryonic antigen (CEA) is a tumour marker commonly associated with gastrointestinal malignancy. Patients presenting with an elevated CEA…”
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PAX8-Peroxisome Proliferator-Activated Receptor γ (PPARγ) Disrupts Normal PAX8 or PPARγ Transcriptional Function and Stimulates Follicular Thyroid Cell Growth by Au, Amy Y. M, McBride, Claire, Wilhelm, Kenneth G, Koenig, Ronald J, Speller, Bridget, Cheung, Linda, Messina, Marinella, Wentworth, John, Tasevski, Vitomir, Learoyd, Diana, Robinson, Bruce G, Clifton-Bligh, Roderick J

“…Follicular thyroid carcinomas are associated with a chromosomal translocation that fuses the thyroid-specific transcription factor paired box gene 8 (PAX8)…”
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Restoring TGF[beta] function in microsatellite unstable (MSI-H) colorectal cancer reduces tumourigenicity but increases metastasis formation by Warusavitarne, Janindra, Mcdougall, Fiona, de Silva, Keshani, Barnetson, Rebecca, Messina, Marinella, Robinson, Bruce G, Schnitzler, Margaret

“…TGFβ is an important cell growth regulator which may have a role in metastasis formation. Microsatellite unstable (MSI-H) colon cancer serves as a unique model…”
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Restoring TGFβ function in microsatellite unstable (MSI-H) colorectal cancer reduces tumourigenicity but increases metastasis formation by Warusavitarne, Janindra, McDougall, Fiona, de Silva, Keshani, Barnetson, Rebecca, Messina, Marinella, Robinson, Bruce G, Schnitzler, Margaret

“…Background TGFβ is an important cell growth regulator which may have a role in metastasis formation. Microsatellite unstable (MSI-H) colon cancer serves as a…”
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Variation of O super(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma by Parkinson, Jonathon F, Wheeler, Helen R, Clarkson, Adele, McKenzie, Catriona A, Biggs, Michael T, Little, Nicholas S, Cook, Raymond J, Messina, Marinella, Robinson, Bruce G, McDonald, Kerrie L

“…Methylation of the promoter region of the O super(6)-methylguanine-DNA methyltransferase (MGMT) gene is known to be predictive of response to temozolomide…”
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PAX8-peroxisome proliferator-activated receptor gamma (PPARgamma) disrupts normal PAX8 or PPARgamma transcriptional function and stimulates follicular thyroid cell growth by Au, Amy Y M, McBride, Claire, Wilhelm, Jr, Kenneth G, Koenig, Ronald J, Speller, Bridget, Cheung, Linda, Messina, Marinella, Wentworth, John, Tasevski, Vitomir, Learoyd, Diana, Robinson, Bruce G, Clifton-Bligh, Roderick J

“…Follicular thyroid carcinomas are associated with a chromosomal translocation that fuses the thyroid-specific transcription factor paired box gene 8 (PAX8)…”
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Restoring TGFbeta function in microsatellite unstable (MSI-H) colorectal cancer reduces tumourigenicity but increases metastasis formation by Warusavitarne, Janindra, McDougall, Fiona, de Silva, Keshani, Barnetson, Rebecca, Messina, Marinella, Robinson, Bruce G, Schnitzler, Margaret

“…TGFbeta is an important cell growth regulator which may have a role in metastasis formation. Microsatellite unstable (MSI-H) colon cancer serves as a unique…”
Get full text