Search Results - "Messi, María Laura"

Accelerated sarcopenia precedes learning and memory impairments in the P301S mouse model of tauopathies and Alzheimer's disease by Longo, Savannah, Messi, María Laura, Wang, Zhong‐Min, Meeker, William, Delbono, Osvaldo

“…Background Alzheimer's disease (AD) impairs cognitive functions and peripheral systems, including skeletal muscles. The PS19 mouse, expressing the human tau…”
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Long‐term, induced expression of Hand2 in peripheral sympathetic neurons ameliorates sarcopenia in geriatric mice by Rodrigues, Anna Carolina Zaia, Messi, María Laura, Wang, Zhong‐Min, Bonilla, Henry Jacob, Freeman, Willard M., Delbono, Osvaldo

“…Background The discovery of adrenoceptors, which mediate the effects of the sympathetic nervous system neurotransmitter norepinephrine on specific tissues,…”
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Heart and neural crest derivative 2‐induced preservation of sympathetic neurons attenuates sarcopenia with aging by Rodrigues, Anna Carolina Zaia, Wang, Zhong‐Min, Messi, María Laura, Bonilla, Henry Jacob, Liu, Liang, Freeman, Willard M., Delbono, Osvaldo

“…Background Sarcopenia, or age‐dependent decline in muscle force and power, impairs mobility, increasing the risk of falls, institutionalization, co‐morbidity,…”
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Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45 by Delbono, Osvaldo, Xia, Jinyu, Treves, Susan, Wang, Zhong-Min, Jimenez-Moreno, Ramon, Payne, Anthony M, Messi, María Laura, Briguet, Alexandre, Schaerer, Florian, Nishi, Miyuki, Takeshima, Hiroshi, Zorzato, Francesco

“…Skeletal muscle constitutes [almost equal to]40% of the human body mass, and alterations in muscle mass and strength may result in physical disability…”
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Patch-clamp recording of charge movement, Ca2+ current, and Ca2+ transients in adult skeletal muscle fibers by Wang, Z M, Messi, M L, Delbono, O

“…Intramembrane charge movement (Q), Ca(2+) conductance (G(m)) through the dihydropyridine-sensitive L-type Ca(2+) channel (DHPR) and intracellular Ca(2+)…”
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Type-2 pericytes participate in normal and tumoral angiogenesis by Birbrair, Alexander, Zhang, Tan, Wang, Zhong-Min, Messi, Maria Laura, Olson, John D, Mintz, Akiva, Delbono, Osvaldo

“…Tissue growth and function depend on vascularization, and vascular insufficiency or excess exacerbates many human diseases. Identification of the biological…”
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Sympathomimetics regulate neuromuscular junction transmission through TRPV1, P/Q- and N-type Ca2+ channels by Rodrigues, Anna Zaia Carolina, Wang, Zhong-Min, Messi, María Laura, Delbono, Osvaldo

“…Increasing evidence indicates that, first, the sympathetic nervous system interacts extensively with both vasculature and skeletal muscle fibers near…”
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The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia by Delbono, Osvaldo, Rodrigues, Anna Carolina Zaia, Bonilla, Henry Jacob, Messi, Maria Laura

“…•Age-dependent decline in muscle mass, force and power characterizes sarcopenia.•The sympathetic nervous system (SNS) regulates neuromuscular junction…”
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Motor neurone targeting of IGF-1 prevents specific force decline in ageing mouse muscle by Payne, Anthony M., Zheng, Zhenlin, Messi, María Laura, Milligan, Carol E., González, Estela, Delbono, Osvaldo

“…IGF-1 is a potent growth factor for both motor neurones and skeletal muscle. Muscle IGF-1 is known to provide target-derived trophic effects on motor neurones…”
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Target-Derived Trophic Effect on Skeletal Muscle Innervation in Senescent Mice by Messi, Maria Laura, Delbono, Osvaldo

“…In the present work, we tested the hypothesis that target-derived insulin-like growth factor-1 (IGF-1) prevents alterations in neuromuscular innervation in…”
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Brainstem noradrenergic neurons: Identifying a hub at the intersection of cognition, motility, and skeletal muscle regulation by Delbono, Osvaldo, Wang, Zhong‐Min, Messi, María Laura

“…Brainstem noradrenergic neuron clusters form a node integrating efferents projecting to distinct areas such as those regulating cognition and skeletal muscle…”
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Role of pericytes in skeletal muscle regeneration and fat accumulation by Birbrair, Alexander, Zhang, Tan, Wang, Zhong-Min, Messi, Maria Laura, Enikolopov, Grigori N, Mintz, Akiva, Delbono, Osvaldo

“…Stem cells ensure tissue regeneration, while overgrowth of adipogenic cells may compromise organ recovery and impair function. In myopathies and muscle atrophy…”
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Aging disrupts locus coeruleus-driven norepinephrine transmission in the prefrontal cortex: Implications for cognitive and motor decline by Budygin, Evgeny, Grinevich, Valentina, Wang, Zhong-Min, Messi, María Laura, Meeker, William Ryan, Zhang, Jie, Stewart, William Matthew, Milligan, Carol, Delbono, Osvaldo

“…The locus coeruleus (LC)-prefrontal cortex (PFC) circuitry is crucial for cognition, planning, posture and mobility. This study examines the role of…”
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Skeletal muscle sympathetic denervation disrupts the neuromuscular junction postterminal organization: A single-cell quantitative approach by Wang, Zhong-Min, Messi, María Laura, Rodrigues, Anna Carolina Zaia, Delbono, Osvaldo

“…The sympathetic nervous system (SNS) regulates skeletal muscle motor innervation and stabilizes the NMJ in health, disease and aging. Previous studies using…”
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Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle by Birbrair, Alexander, Zhang, Tan, Wang, Zhong-Min, Messi, Maria Laura, Mintz, Akiva, Delbono, Osvaldo

“…In older adults, changes in skeletal muscle composition are associated with increased fibrosis, loss of mass, and decreased force, which can lead to…”
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Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults by Messi, María Laura, Li, Tao, Wang, Zhong-Min, Marsh, Anthony P, Nicklas, Barbara, Delbono, Osvaldo

“…Studies in humans and animal models provide compelling evidence for age-related skeletal muscle denervation, which may contribute to muscle fiber atrophy and…”
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Sex differences in single neuron function and proteomics profiles examined by patch‐clamp and mass spectrometry in the locus coeruleus of the adult mouse by Lee, Jingyun, Wang, Zhong‐Min, Messi, María Laura, Milligan, Carol, Furdui, Cristina M., Delbono, Osvaldo

“…Aims This study aimed to characterize the properties of locus coeruleus (LC) noradrenergic neurons in male and female mice. We also sought to investigate…”
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Skeletal muscle neural progenitor cells exhibit properties of NG2-glia by Birbrair, Alexander, Zhang, Tan, Wang, Zhong-Min, Messi, María Laura, Enikolopov, Grigori N., Mintz, Akiva, Delbono, Osvaldo

“…Reversing brain degeneration and trauma lesions will depend on cell therapy. Our previous work identified neural precursor cells derived from the skeletal…”
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Overexpression of IGF-1 Exclusively in Skeletal Muscle Prevents Age-related Decline in the Number of Dihydropyridine Receptors by Renganathan, Muthukrishnan, Messi, Marı́a Laura, Delbono, Osvaldo

“…Excitation-contraction uncoupling has been identified as a mechanism underlying skeletal muscle weakness in aging mammals (sarcopenia). The basic mechanism for…”
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Role of Sustained Overexpression of Central Nervous System IGF-I in the Age-Dependent Decline of Mouse Excitation-Contraction Coupling by Moreno, Ramón Jiménez, Messi, María Laura, Zheng, Zhenlin, Wang, Zhong-Min, Ye, Ping, D'Ercole, Joseph A, Delbono, Osvaldo

“…We investigated the effects of exclusive and sustained transgenic overexpression of insulin-like growth factor (IGF)-I in the central nervous system (CNS) on…”
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