Search Results - "Messerschmidt, M"

DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos by Messerschmidt, Daniel M, Knowles, Barbara B, Solter, Davor

“…Methylation of DNA is an essential epigenetic control mechanism in mammals. During embryonic development, cells are directed toward their future lineages, and…”
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Experimental demonstration of femtosecond two-color x-ray free-electron lasers by Lutman, A A, Coffee, R, Ding, Y, Huang, Z, Krzywinski, J, Maxwell, T, Messerschmidt, M, Nuhn, H-D

“…With an eye toward extending optical wave-mixing techniques to the x-ray regime, we present the first experimental demonstration of a two-color x-ray…”
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Ultrafast X-ray probing of water structure below the homogeneous ice nucleation temperature by Sellberg, J. A., Huang, C., McQueen, T. A., Loh, N. D., Laksmono, H., Schlesinger, D., Sierra, R. G., Nordlund, D., Hampton, C. Y., Starodub, D., DePonte, D. P., Beye, M., Chen, C., Martin, A. V., Barty, A., Wikfeldt, K. T., Weiss, T. M., Caronna, C., Feldkamp, J., Skinner, L. B., Seibert, M. M., Messerschmidt, M., Williams, G. J., Boutet, S., Pettersson, L. G. M., Bogan, M. J., Nilsson, A.

“…Femtosecond X-ray laser pulses are used to probe the structure of liquid water in micrometre-sized droplets that have been cooled below the homogeneous ice…”
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First lasing and operation of an ångstrom-wavelength free-electron laser by Arthur, J, Nuhn, H.-D, Tompkins, H, Bucksbaum, P, Galayda, J, Frisch, J, Welch, J, Hering, Ph, Hastings, J, Pile, G, Decker, F.-J, Brachmann, A, Stefan, P, Loos, H, Bozek, J, Wu, J, Miahnahri, A, Schultz, D, Smith, T, Coffee, R, Yocky, G, Gilevich, S, Messerschmidt, M, Bostedt, C, White, W, Emma, P, Huang, Z, Turner, J, Moeller, S, Bionta, R, Edstrom, S, Hays, G, Ding, Y, Iverson, R, Ratner, D, Fisher, A, Rzepiela, J, Akre, R, Dowell, D

“…The recently commissioned Linac Coherent Light Source is an X-ray free-electron laser at the SLAC National Accelerator Laboratory. It produces coherent soft…”
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Ultrafast Three-Dimensional Imaging of Lattice Dynamics in Individual Gold Nanocrystals by Clark, J. N., Beitra, L., Xiong, G., Higginbotham, A., Fritz, D. M., Lemke, H. T., Zhu, D., Chollet, M., Williams, G. J., Messerschmidt, M., Abbey, B., Harder, R. J., Korsunsky, A. M., Wark, J. S., Robinson, I. K.

“…Key insights into the behavior of materials can be gained by observing their structure as they undergo lattice distortion. Laser pulses on the femtosecond time…”
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ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice by Ho, Lena, van Dijk, Marie, Chye, Sam Tan Jian, Messerschmidt, Daniel M., Chng, Serene C., Ong, Sheena, Yi, Ling Ka, Boussata, Souad, Goh, Grace Hui-Yi, Afink, Gijs B., Lim, Chin Yan, Dunn, N. Ray, Solter, Davor, Knowles, Barbara B., Reversade, Bruno

“…Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal…”
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Nanoscale spin reversal by non-local angular momentum transfer following ultrafast laser excitation in ferrimagnetic GdFeCo by Graves, C. E., Reid, A. H., Wang, T., Wu, B., de Jong, S., Vahaplar, K., Radu, I., Bernstein, D. P., Messerschmidt, M., Müller, L., Coffee, R., Bionta, M., Epp, S. W., Hartmann, R., Kimmel, N., Hauser, G., Hartmann, A., Holl, P., Gorke, H., Mentink, J. H., Tsukamoto, A., Fognini, A., Turner, J. J., Schlotter, W. F., Rolles, D., Soltau, H., Strüder, L., Acremann, Y., Kimel, A. V., Kirilyuk, A., Rasing, Th, Stöhr, J., Scherz, A. O., Dürr, H. A.

“…The dynamics of thin magnetic films revealed by ultrafast laser techniques cannot be explained by standard equilibrium descriptions. Diffraction experiments…”
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Femtosecond Visualization of Lattice Dynamics in Shock-Compressed Matter by Milathianaki, D., Boutet, S., Williams, G. J., Higginbotham, A., Ratner, D., Gleason, A. E., Messerschmidt, M., Seibert, M. M., Swift, D. C., Hering, P., Robinson, J., White, W. E., Wark, J. S.

“…The ultrafast evolution of microstructure is key to understanding high-pressure and strain-rate phenomena. However, the visualization of lattice dynamics at…”
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Pink-beam serial crystallography by Meents, A., Wiedorn, M. O., Srajer, V., Henning, R., Sarrou, I., Bergtholdt, J., Barthelmess, M., Reinke, P. Y. A., Dierksmeyer, D., Tolstikova, A., Schaible, S., Messerschmidt, M., Ogata, C. M., Kissick, D. J., Taft, M. H., Manstein, D. J., Lieske, J., Oberthuer, D., Fischetti, R. F., Chapman, H. N.

“…Serial X-ray crystallography allows macromolecular structure determination at both X-ray free electron lasers (XFELs) and, more recently, synchrotron sources…”
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Direct measurements of the ionization potential depression in a dense plasma by Ciricosta, O, Vinko, S M, Chung, H-K, Cho, B-I, Brown, C R D, Burian, T, Chalupský, J, Engelhorn, K, Falcone, R W, Graves, C, Hájková, V, Higginbotham, A, Juha, L, Krzywinski, J, Lee, H J, Messerschmidt, M, Murphy, C D, Ping, Y, Rackstraw, D S, Scherz, A, Schlotter, W, Toleikis, S, Turner, J J, Vysin, L, Wang, T, Wu, B, Zastrau, U, Zhu, D, Lee, R W, Heimann, P, Nagler, B, Wark, J S

“…We have used the Linac Coherent Light Source to generate solid-density aluminum plasmas at temperatures of up to 180 eV. By varying the photon energy of the x…”
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A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo by Do, Dang Vinh, Ueda, Jun, Messerschmidt, Daniel M, Lorthongpanich, Chanchao, Zhou, Yi, Feng, Bo, Guo, Guoji, Lin, Peiyu J, Hossain, Md Zakir, Zhang, Wenjun, Moh, Akira, Wu, Qiang, Robson, Paul, Ng, Huck Hui, Poellinger, Lorenz, Knowles, Barbara B, Solter, Davor, Fu, Xin-Yuan

“…Although it is known that OCT4-NANOG are required for maintenance of pluripotent cells in vitro, the upstream signals that regulate this circuit during early…”
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Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation by Lorthongpanich, Chanchao, Messerschmidt, Daniel M, Chan, Siew Wee, Hong, Wanjin, Knowles, Barbara B, Solter, Davor

“…Cellular localization of the Yes-associated protein (YAP) is dependent on large tumor suppressor (LATS) kinase activity and initiates lineage specification in…”
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Single-Cell DNA-Methylation Analysis Reveals Epigenetic Chimerism in Preimplantation Embryos by Lorthongpanich, Chanchao, Cheow, Lih Feng, Balu, Sathish, Quake, Stephen R., Knowles, Barbara B., Burkholder, William F., Solter, Davor, Messerschmidt, Daniel M.

“…Epigenetic alterations are increasingly recognized as causes of human cancers and disease. These aberrations are likely to arise during genomic reprogramming…”
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Measuring the temporal structure of few-femtosecond free-electron laser X-ray pulses directly in the time domain by Helml, W., Maier, A. R., Schweinberger, W., Grguraš, I., Radcliffe, P., Doumy, G., Roedig, C., Gagnon, J., Messerschmidt, M., Schorb, S., Bostedt, C., Grüner, F., DiMauro, L. F., Cubaynes, D., Bozek, J. D., Tschentscher, Th, Costello, J. T., Meyer, M., Coffee, R., Düsterer, S., Cavalieri, A. L., Kienberger, R.

“…Short-wavelength free-electron lasers are now well established as essential and unrivalled sources of ultrabright coherent X-ray radiation. One of the key…”
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Nonlinear atomic response to intense ultrashort x rays by Doumy, G, Roedig, C, Son, S-K, Blaga, C I, DiChiara, A D, Santra, R, Berrah, N, Bostedt, C, Bozek, J D, Bucksbaum, P H, Cryan, J P, Fang, L, Ghimire, S, Glownia, J M, Hoener, M, Kanter, E P, Krässig, B, Kuebel, M, Messerschmidt, M, Paulus, G G, Reis, D A, Rohringer, N, Young, L, Agostini, P, DiMauro, L F

“…The nonlinear absorption mechanisms of neon atoms to intense, femtosecond kilovolt x rays are investigated. The production of Ne(9+) is observed at x-ray…”
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Spectral encoding of x-ray/optical relative delay by Bionta, Mina R, Lemke, H T, Cryan, J P, Glownia, J M, Bostedt, C, Cammarata, M, Castagna, J-C, Ding, Y, Fritz, D M, Fry, A R, Krzywinski, J, Messerschmidt, M, Schorb, S, Swiggers, M L, Coffee, R N

“…We present a new technique for measuring the relative delay between a soft x-ray FEL pulse and an optical laser that indicates a sub 25 fs RMS measurement…”
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Coherence properties of individual femtosecond pulses of an x-ray free-electron laser by Vartanyants, I A, Singer, A, Mancuso, A P, Yefanov, O M, Sakdinawat, A, Liu, Y, Bang, E, Williams, G J, Cadenazzi, G, Abbey, B, Sinn, H, Attwood, D, Nugent, K A, Weckert, E, Wang, T, Zhu, D, Wu, B, Graves, C, Scherz, A, Turner, J J, Schlotter, W F, Messerschmidt, M, Lüning, J, Acremann, Y, Heimann, P, Mancini, D C, Joshi, V, Krzywinski, J, Soufli, R, Fernandez-Perea, M, Hau-Riege, S, Peele, A G, Feng, Y, Krupin, O, Moeller, S, Wurth, W

“…Measurements of the spatial and temporal coherence of single, femtosecond x-ray pulses generated by the first hard x-ray free-electron laser, the Linac…”
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In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors by Nass, Karol, Redecke, Lars, Perbandt, M., Yefanov, O., Klinge, M., Koopmann, R., Stellato, F., Gabdulkhakov, A., Schönherr, R., Rehders, D., Lahey-Rudolph, J. M., Aquila, A., Barty, A., Basu, S., Doak, R. B., Duden, R., Frank, M., Fromme, R., Kassemeyer, S., Katona, G., Kirian, R., Liu, H., Majoul, I., Martin-Garcia, J. M., Messerschmidt, M., Shoeman, R. L., Weierstall, U., Westenhoff, S., White, T. A., Williams, G. J., Yoon, C. H., Zatsepin, N., Fromme, P., Duszenko, M., Chapman, H. N., Betzel, C.

“…Sleeping sickness is a fatal disease caused by the protozoan parasite Trypanosoma brucei (Tb). Inosine-5’-monophosphate dehydrogenase (IMPDH) has been proposed…”
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Bicycle accidents - do we only see the tip of the iceberg? A prospective multi-centre study in a large German city combining medical and police data by Juhra, C, Wieskötter, B, Chu, K, Trost, L, Weiss, U, Messerschmidt, M, Malczyk, A, Heckwolf, M, Raschke, M

“…Bicycles are becoming increasingly popular. In Münster, a German town with a population of 273,000, bicycles were the main method of transportation in 2009,…”
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Creation and diagnosis of a solid-density plasma with an X-ray free-electron laser by Vinko, S. M., Ciricosta, O., Cho, B. I., Engelhorn, K., Chung, H.-K., Brown, C. R. D., Burian, T., Chalupský, J., Falcone, R. W., Graves, C., Hájková, V., Higginbotham, A., Juha, L., Krzywinski, J., Lee, H. J., Messerschmidt, M., Murphy, C. D., Ping, Y., Scherz, A., Schlotter, W., Toleikis, S., Turner, J. J., Vysin, L., Wang, T., Wu, B., Zastrau, U., Zhu, D., Lee, R. W., Heimann, P. A., Nagler, B., Wark, J. S.

“…Experimental study of the interactions between intense X-rays and solid matter illustrate the generation of a solid-density plasma governed by electron–ion…”
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