Search Results - "Messer, Jürg"

In Vitro Binding Properties in Rat Brain of [3H]Ro 25‐6981, a Potent and Selective Antagonist of NMDA Receptors Containing NR2B Subunits by Mutel, Vincent, Buchy, Danièle, Klingelschmidt, Agnès, Messer, Jürg, Bleuel, Zaiga, Kemp, John A., Richards, John Grayson

“…: The in vitro binding of a new subtype‐selective NMDA receptor antagonist, [3H]Ro 25‐6981, to rat brain membranes and sections was characterized. The compound…”
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Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β by Bohrmann, Bernd, Baumann, Karlheinz, Benz, Jörg, Gerber, Francoise, Huber, Walter, Knoflach, Frédéric, Messer, Jürg, Oroszlan, Krisztina, Rauchenberger, Robert, Richter, Wolfgang F, Rothe, Christine, Urban, Margit, Bardroff, Michael, Winter, Michael, Nordstedt, Christer, Loetscher, Hansruedi

“…The amyloid-β lowering capacity of anti-Aβ antibodies has been demonstrated in transgenic models of Alzheimer's disease (AD) and in AD patients. While the…”
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Characterization of (2S,2′R,3′R)‐2‐(2′,3′‐[3H]‐Dicarboxycyclopropyl)glycine Binding in Rat Brain by Mutel, Vincent, Adam, Geo, Chaboz, Sylvie, Kemp, John A., Klingelschmidt, Agnés, Messer, Jürg, Wichmann, Jürgen, Woltering, Thomas, Richards, John Grayson

“…: [(2S,2′R,3′R)‐2‐(2′,3′‐[3H]Dicarboxycyclopropyl)glycine ([3H]DCG IV) binding was characterized in vitro in rat brain cortex homogenates and rat brain…”
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Altered distribution of mGlu2 receptors in β-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice by Richards, Grayson, Messer, Jürg, Faull, Richard L.M, Stadler, Heinz, Wichmann, Jürgen, Huguenin, Philipp, Bohrmann, Bernd, Mutel, Vincent

“…Abstract Altered glutamatergic synaptic transmission is among the key events defining the course of Alzheimer's disease (AD). mGlu2 receptors, a subtype of…”
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Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: Correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPγs binding by Richards, Grayson, Messer, Jürg, Malherbe, Pari, Pink, Richard, Brockhaus, Manfred, Stadler, Heinz, Wichmann, Jürgen, Schaffhauser, Hervé, Mutel, Vincent

“…Until recently, there was a lack of selective radioligands for the subtypes of metabotropic glutamate (mGlu) receptors. [3H]LY354740…”
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A comparative study of binding properties of gantenerumab and aducanumab analog to aggregated amyloid-beta (P6.087) by Bohrmann, Bernd, Oroszlan-Szovik, Krisztina, Anquez, Viviane, Baumann, Karlheinz, Kusznir, Eric, Gerber, Francoise, Messer, Jürg, Huber, Sylwia, Niewoehner, Jens, Richter, Wolfgang, Tiefenthaler, Georg

“…Abstract only…”
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Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPgammas binding by Richards, Grayson, Messer, Jürg, Malherbe, Pari, Pink, Richard, Brockhaus, Manfred, Stadler, Heinz, Wichmann, Jürgen, Schaffhauser, Hervé, Mutel, Vincent

“…Until recently, there was a lack of selective radioligands for the subtypes of metabotropic glutamate (mGlu) receptors. [(3)H]LY354740…”
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In vitro binding characteristics of a new selective group II metabotropic glutamate receptor radioligand, [3H]LY354740, in rat brain by Schaffhauser, H, Richards, J G, Cartmell, J, Chaboz, S, Kemp, J A, Klingelschmidt, A, Messer, J, Stadler, H, Woltering, T, Mutel, V

“…The in vitro binding of [3H]LY354740, the first high affinity group II-selective metabotropic glutamate (mGlu) receptor radioligand, was characterized in rat…”
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Characterization of [3H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections by Mutel, Vincent, Ellis, Gareth J., Adam, Geo, Chaboz, Sylvie, Nilly, Agnes, Messer, Jürg, Bleuel, Zaiga, Metzler, Veit, Malherbe, Pari, Schlaeger, Ernst‐Jürgen, Roughley, Brian S., Faull, Richard L. M., Richards, J. Grayson

“…: We have investigated the binding properties of[3H]quisqualate to rat metabotropic glutamate (mGlu) 1a and 5areceptors and to rat and human brain sections…”
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Opposite effects of Zn on the in vitro binding of [3H]LY354740 to recombinant and native metabotropic glutamate 2 and 3 receptors by Malherbe, Pari, Richards, J. Grayson, Broger, Clemens, Zenner, Marie‐Thérèse, Messer, Jürg, Kratzeisen, Claudia, Nakanishi, Shigetada, Mutel, Vincent

“…We investigated the effect of Zn on agonist binding to both recombinant and native mGlu2 and mGlu3 receptors. Zn had a biphasic inhibitory effect on…”
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Binding Characteristics of a Potent AMPA Receptor Antagonist [3H]Ro 48‐8587 in Rat Brain by Mutel, Vincent, Trube, Gerhard, Klingelschmidt, Agnès, Messer, Jürg, Bleuel, Zaiga, Humbel, Urs, Clifford, Merwyn M., Ellis, Gareth J., Richards, J. Grayson

“…: A new AMPA receptor antagonist, Ro 48‐8587, was characterized pharmacologically in vitro. It is highly potent and selective for AMPA receptors as shown by…”
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Characterization of behavioral response to amphetamine, tyrosine hydroxylase levels, and dopamine receptor levels in neurokinin 3 receptor knockout mice by Nordquist, Rebecca E, Savignac, Helene, Pauly-Evers, Meike, Walker, Gaby, Knoflach, Fred, Borroni, Edilio, Glaentzlin, Patricia, Bohrmann, Bernd, Messer, Jurg, Ozmen, Laurence, Albientz, Anita, Spooren, Will

“…The neurokinin 3 (NK3) receptor is a novel target under investigation for improvement of symptoms of schizophrenia, because of its ability to modulate…”
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