Search Results - "Messaoudi, Smail"

Mineralocorticoid receptor antagonism improves diastolic dysfunction in chronic kidney disease in mice by Bonnard, Benjamin, Pieronne-Deperrois, Marie, Djerada, Zoubir, Elmoghrabi, Soumaya, Kolkhof, Peter, Ouvrard-Pascaud, Antoine, Mulder, Paul, Jaisser, Frédéric, Messaoudi, Smail

“…Managing the cardiovascular complications of renal failure is a major therapeutic challenge in clinical practice. Mineralocorticoid Receptor (MR) blockade is a…”
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Aldosterone-Specific Activation of Cardiomyocyte Mineralocorticoid Receptor In Vivo by Messaoudi, Smail, Gravez, Basile, Tarjus, Antoine, Pelloux, Véronique, Ouvrard-Pascaud, Antoine, Delcayre, Claude, Samuel, Janelise, Launay, Jean-Marie, Sierra-Ramos, Catalina, de la Rosa, Diego Alvarez, Clément, Karine, Farman, Nicolette, Jaisser, Fréderic

“…Inappropriate mineralocorticoid receptor (MR) activation is involved in cardiac diseases. Whether and how aldosterone is involved in the deleterious effects of…”
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Endothelial Gata5 transcription factor regulates blood pressure by Messaoudi, Smail, He, Ying, Gutsol, Alex, Wight, Andrew, Hébert, Richard L., Vilmundarson, Ragnar O., Makrigiannis, Andrew P., Chalmers, John, Hamet, Pavel, Tremblay, Johanne, McPherson, Ruth, Stewart, Alexandre F. R., Touyz, Rhian M., Nemer, Mona

“…Despite its high prevalence and economic burden, the aetiology of human hypertension remains incompletely understood. Here we identify the transcription factor…”
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Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure by Milliez, Paul, Messaoudi, Smail, Nehme, Johnny, Rodriguez, Camille, Samuel, Jane-Lise, Delcayre, Claude

“…We tested the hypothesis that heart rate (HR) reduction, induced by the selective hyperpolarization-activated current inhibitor ivabradine (Iva), might improve…”
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The diuretic torasemide does not prevent aldosterone-mediated mineralocorticoid receptor activation in cardiomyocytes by Gravez, Basile, Tarjus, Antoine, Jimenez-Canino, Ruben, El Moghrabi, Soumaya, Messaoudi, Smail, Alvarez de la Rosa, Diego, Jaisser, Frederic

“…Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption. Excessive mineralocorticoid…”
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Cross-Talk Between Mineralocorticoid and Angiotensin II Signaling for Cardiac Remodeling by Zhang, An Di, Cat, Aurelie Nguyen Dinh, Soukaseum, Christelle, Escoubet, Brigitte, Cherfa, Aïcha, Messaoudi, Smail, Delcayre, Claude, Samuel, Jane-Lise, Jaisser, Frederic

“…Experimental and clinical studies show that aldosterone/mineralocorticoid receptor (MR) activation has deleterious effects in the cardiovascular system that…”
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The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling by Messaoudi, Smail, Zhang, An Di, Griol-Charhbili, Violaine, Escoubet, Brigitte, Sadoshima, Junichi, Farman, Nicolette, Jaisser, Frederic

“…Experimental and clinical studies have shown that aldosterone/mineralocorticoid receptor (MR) activation has deleterious effects in the cardiovascular system;…”
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Aldosterone promotes cardiac endothelial cell proliferation in vivo by Gravez, Basile, Tarjus, Antoine, Pelloux, Véronique, Ouvrard-Pascaud, Antoine, Delcayre, Claude, Samuel, Janelise, Clément, Karine, Farman, Nicolette, Jaisser, Fréderic, Messaoudi, Smail

“…Experimentally, aldosterone in association with NaCl induces cardiac fibrosis, oxidative stress, and inflammation through mineralocorticoid receptor…”
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Aldosterone, mineralocorticoid receptor, and heart failure by Messaoudi, Smail, Azibani, Feriel, Delcayre, Claude, Jaisser, Frederic

“…► We review aldosterone and mineralocorticoid receptor actions in the heart. ► Recent findings from clinical trials and animal studies are discussed. ►…”
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Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury–Mediated Chronic Kidney Disease: Role of Oxidative Stress by Lattenist, Lionel, Lechner, Sebastian M, Messaoudi, Smail, Le Mercier, Alan, El Moghrabi, Soumaya, Prince, Sonia, Bobadilla, Norma A, Kolkhof, Peter, Jaisser, Frédéric, Barrera-Chimal, Jonatan

“…Acute kidney injury induced by ischemia/reperfusion (IR) is a frequent complication in hospitalized patients. Mineralocorticoid receptor antagonism has shown…”
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Cardiomyocyte-specific overexpression of oestrogen receptor β improves survival and cardiac function after myocardial infarction in female and male mice by Schuster, Iris, Mahmoodzadeh, Shokoufeh, Dworatzek, Elke, Jaisser, Frédéric, Messaoudi, Smail, Morano, Ingo, Regitz-Zagrosek, Vera

“…ERβ (oestrogen receptor β) activation has been shown to be cardioprotective, but the cell types and mechanisms involved are not understood. To investigate…”
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Abstract 320: Gata5 Null Mice: A New Genetic Model Of Low-Renin Salt-Sensitive Hypertension by Messaoudi, Smail, Gutsol, Alex, Hébert, Richard L, Nemer, Mona

“…Abstract only GATA5, a transcription factor of the GATA family, is expressed in the kidney where its function is unknown. In mice, inactivation of GATA5 leads…”
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Epidermal Growth Factor Receptor Mediates the Vascular Dysfunction But Not the Remodeling Induced by Aldosterone/Salt by Griol-Charhbili, Violaine, Fassot, Céline, Messaoudi, Smail, Perret, Claudine, Agrapart, Vincent, Jaisser, Frederic

“…Pathophysiological aldosterone (aldo)/mineralocorticoid receptor signaling has a major impact on the cardiovascular system, resulting in hypertension and…”
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Neutrophil Gelatinase-Associated Lipocalin Is a Novel Mineralocorticoid Target in the Cardiovascular System by Latouche, Celine, El Moghrabi, Soumaya, Messaoudi, Smail, Nguyen Dinh Cat, Aurélie, Hernandez-Diaz, Ivan, Alvarez de la Rosa, Diego, Perret, Claudine, López Andrés, Natalia, Rossignol, Patrick, Zannad, Faiez, Farman, Nicolette, Jaisser, Frederic

“…Mineralocorticoid receptor (MR) activation may be deleterious to the cardiovascular system, and MR antagonists improve morbidity and mortality of patients with…”
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Aldosterone and the mineralocorticoid receptor: Utility of blocking aldosterone in the treatment of cardiovascular disease by MESSAOUDI, Smail, JAISSER, Frederic

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Cardiac aldosterone overexpression prevents harmful effects of diabetes in the mouse heart by preserving capillary density by Messaoudi, Smail, Milliez, Paul, Samuel, Jane-Lise, Delcayre, Claude

“…Recent reports showed an unexpected worsening of endothelial function by aldosterone antagonism in diabetic patients, suggesting that aldosterone could…”
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Aldosterone and the mineralocorticoid receptor by Messaoudi, Smail, Jaisser, Frédéric

“…For decades, the role of aldosterone was thought to be limited to salt and water homeostasis control. This traditional view of the action of aldosterone…”
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Eplerenone administration has beneficial effect on hepatic paraoxonase 1 activity in diabetic mice by Noll, Christophe, Messaoudi, Smail, Milliez, Paul, Samuel, Jane-Lise, Delcayre, Claude, Janel, Nathalie

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411 NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN IS A NOVEL MINERALOCORTICOID TARGET IN THE CARDIOVASCULAR SYSTEM by Latouche, Celine, Moghrabi, Soumaya El, Dinh Cat, Aurélie Nguyen, Messaoudi, Smail, Hernandez-Diaz, Ivan, de la Rosa, Diego Alvarez, Perret, Claudine, Andrés, Natalia López, Rossignol, Patrick, Zannad, Faiez, Azizi, Michel, Farman, Nicolette, Jaisser, Frederic

“…BACKGROUND:Mineralocorticoid receptor (MR) activation may be deleterious to the cardiovascular system and MR antagonists improve morbidity and mortality of…”
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Aldosterone prevents deleterious effects of diabetes in mouse hearts by Messaoudi, Smail, Milliez, Paul, Samuel, Jane-Lise, Delcayre, Claude

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