Search Results - "Message, Simon"

Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium by Slater, Louise, Bartlett, Nathan W, Haas, Jennifer J, Zhu, Jie, Message, Simon D, Walton, Ross P, Sykes, Annemarie, Dahdaleh, Samer, Clarke, Deborah L, Belvisi, Maria G, Kon, Onn M, Fujita, Takashi, Jeffery, Peter K, Johnston, Sebastian L, Edwards, Michael R

“…The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the…”
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Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations by Zhu, Jie, Message, Simon D., Mallia, Patrick, Kebadze, Tatiana, Contoli, Marco, Ward, Christine K., Barnathan, Elliot S., Mascelli, Mary Ann, Kon, Onn M., Papi, Alberto, Stanciu, Luminita A., Edwards, Michael R., Jeffery, Peter K., Johnston, Sebastian L.

“…The innate immune system senses viral infection through pattern recognition receptors (PRRs), leading to type I interferon production. The role of type I…”
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Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease by MALLIA, Patrick, FOOTITT, Joseph, MESSAGE, Simon D, ITO, Kazuhiro, BARNES, Peter J, ADCOCK, Ian M, PAPI, Alberto, STANCIU, Luminita A, ELKIN, Sarah L, KON, Onn M, JOHNSON, Malcolm, JOHNSTON, Sebastian L, SOTERO, Rosa, JEPSON, Annette, CONTOLI, Marco, TRUJILLO-TORRALBO, Maria-Belen, KEBADZE, Tatiana, ANISCENKO, Julia, OLESZKIEWICZ, Gregory, GRAY, Katrina

“…Chronic obstructive pulmonary disease (COPD) exacerbations are associated with virus (mostly rhinovirus) and bacterial infections, but it is not known whether…”
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Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production by Message, Simon D, Laza-Stanca, Vasile, Mallia, Patrick, Parker, Hayley L, Zhu, Jie, Kebadze, Tatiana, Contoli, Marco, Sanderson, Gwen, Kon, Onn M, Papi, Alberto, Jeffery, Peter K, Stanciu, Luminita A, Johnston, Sebastian L

“…Acute exacerbations are the major cause of asthma morbidity, mortality, and health-care costs and are difficult to treat and prevent. The majority of asthma…”
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Airway Inflammation and Illness Severity in Response to Experimental Rhinovirus Infection in Asthma by Zhu, Jie, MD, PhD, Message, Simon D., MD, PhD, Qiu, Yusheng, MD, PhD, Mallia, Patrick, MD, PhD, Kebadze, Tatiana, MD, Contoli, Marco, MD, Ward, Christine K., PhD, Barnathan, Elliot S., MD, Mascelli, Mary Ann, PhD, Kon, Onn M., MD, Papi, Alberto, MD, FCCP, Stanciu, Luminita A., MD, PhD, Jeffery, Peter K., PhD, DSc, Johnston, Sebastian L., PhD

“…Background The nature of bronchial mucosal inflammation and its physiologic and clinical significance in rhinovirus-induced asthma exacerbations is unclear. We…”
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Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation by MALLIA, Patrick, MESSAGE, Simon D, PAPI, Alberto, STANCIU, Luminita A, KON, Onn M, JOHNSON, Malcolm, JOHNSTON, Sebastian L, GIELEN, Vera, CONTOLI, Marco, GRAY, Katrina, KEBADZE, Tatiana, ANISCENKO, Julia, LAZA-STANCA, Vasile, EDWARDS, Michael R, SLATER, Louise

“…Respiratory virus infections are associated with chronic obstructive pulmonary disease (COPD) exacerbations, but a causative relationship has not been proven…”
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Loss of regulatory capacity in Treg cells following rhinovirus infection by Jansen, Kirstin, Wirz, Oliver F., van de Veen, Willem, Tan, Ge, Mirer, David, Sokolowska, Milena, Satitsuksanoa, Pattraporn, Message, Simon D., Kebadze, Tatiana, Glanville, Nicholas, Mallia, Patrick, Skiepko, Roman, Eljaszewicz, Andrzej, Moniuszko, Marcin, Cardoso, Carlos, Gern, James E., Papadopoulos, Nikolaos G., Akdis, Cezmi A., Johnston, Sebastian L., Nadeau, Kari C., Akdis, Mübeccel

“…Respiratory infections with rhinoviruses (RV) are strongly associated with development and exacerbations of asthma, and they pose an additional health risk for…”
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T regulatory cells from atopic asthmatic individuals show a Th2‐like phenotype by Jansen, Kirstin, Satitsuksanoa, Pattraporn, Wirz, Oliver F., Schneider, Stephan R., van de Veen, Willem, Tan, Ge, Sokolowska, Milena, Message, Simon D., Kebadze, Tatiana, Glanville, Nicholas, Mallia, Patrick, Akdis, Cezmi A., Moniuszko, Marcin, Johnston, Sebastian L., Nadeau, Kari, Akdis, Mübeccel

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Experimental rhinovirus infection induces an antiviral response in circulating B cells which is dysregulated in patients with asthma by Wirz, Oliver F., Jansen, Kirstin, Satitsuksanoa, Pattraporn, Veen, Willem, Tan, Ge, Sokolowska, Milena, Mirer, David, Stanić, Barbara, Message, Simon D., Kebadze, Tatiana, Glanville, Nicholas, Mallia, Patrick, Gern, James E., Papadopoulos, Nikolaos, Akdis, Cezmi A., Johnston, Sebastian L., Nadeau, Kari, Akdis, Mübeccel

“…Background Rhinoviruses are the predominant cause of respiratory viral infections and are strongly associated with asthma exacerbations. While humoral immunity…”
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Role of deficient type III interferon-λ production in asthma exacerbations by Johnston, Sebastian L, Contoli, Marco, Message, Simon D, Laza-Stanca, Vasile, Edwards, Michael R, Wark, Peter A B, Bartlett, Nathan W, Kebadze, Tatiana, Mallia, Patrick, Stanciu, Luminita A, Parker, Hayley L, Slater, Louise, Lewis-Antes, Anita, Kon, Onn M, Holgate, Stephen T, Davies, Donna E, Kotenko, Sergei V, Papi, Alberto

“…Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections…”
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Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD by Zhu, Jie, Mallia, Patrick, Footitt, Joseph, Qiu, Yusheng, Message, Simon D., Kebadze, Tatiana, Aniscenko, Julia, Barnes, Peter J., Adcock, Ian M., Kon, Onn M., Johnson, Malcolm, Contoli, Marco, Stanciu, Luminita A., Papi, Alberto, Jeffery, Peter K., Johnston, Sebastian L.

“…Respiratory viral infection causes chronic obstructive pulmonary disease (COPD) exacerbations. We previously reported increased bronchial mucosa eosinophil and…”
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Cilomilast Modulates Rhinovirus-Induced Airway Epithelial ICAM-1 Expression and IL-6, CXCL8 and CCL5 Production by Zhu, Jie, Edwards, Michael R., Message, Simon D., Stanciu, Luminita A., Johnston, Sebastian L., Jeffery, Peter K.

“…Background: Cilomilast, a phosphodiesterase-4 (PDE4) selective inhibitor, has anti-inflammatory effects in vitro and in vivo and reduces COPD exacerbations. We…”
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The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations by Laza-Stanca, Vasile, Message, Simon D, Edwards, Michael R, Parker, Hayley L, Zdrenghea, Mihnea T, Kebadze, Tatiana, Kon, Onn M, Mallia, Patrick, Stanciu, Luminita A, Johnston, Sebastian L

“…Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity,…”
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An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: a pilot study by Mallia, Patrick, Message, Simon D, Kebadze, Tatiana, Parker, Hayley L, Kon, Onn M, Johnston, Sebastian L

“…Acute exacerbations of COPD are a major cause of morbidity, mortality and hospitalisation. Respiratory viruses are associated with the majority of…”
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Host defense function of the airway epithelium in health and disease: clinical background by Message, Simon D., Johnston, Sebastian L.

“…Respiratory infection is extremely common and a major cause of morbidity and mortality worldwide. The airway epithelium has an important role in host defense…”
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Defining critical roles for NF‐κB p65 and type I interferon in innate immunity to rhinovirus by Bartlett, Nathan W., Slater, Louise, Glanville, Nicholas, Haas, Jennifer J., Caramori, Gaetano, Casolari, Paolo, Clarke, Deborah L., Message, Simon D., Aniscenko, Julia, Kebadze, Tatiana, Zhu, Jie, Mallia, Patrick, Mizgerd, Joseph P., Belvisi, Maria, Papi, Alberto, Kotenko, Sergei V., Johnston, Sebastian L., Edwards, Michael R.

“…The importance of NF‐κB activation and deficient anti‐viral interferon induction in the pathogenesis of rhinovirus‐induced asthma exacerbations is poorly…”
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Neutrophil adhesion molecules in experimental rhinovirus infection in COPD by Mallia, Patrick, Message, Simon D, Contoli, Marco, Gray, Katrina K, Telcian, Aurica, Laza-Stanca, Vasile, Papi, Alberto, Stanciu, Luminita A, Elkin, Sarah, Kon, Onn M, Johnson, Malcolm, Johnston, Sebastian L

“…COPD exacerbations are associated with neutrophilic airway inflammation. Adhesion molecules on the surface of neutrophils may play a key role in their movement…”
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Rhinovirus Replication in Human Macrophages Induces NF-κB-Dependent Tumor Necrosis Factor Alpha Production by LAZA-STANCA, Vasile, STANCIU, Luminita A, MESSAGE, Simon D, EDWARDS, Michael R, GERN, James E, JOHNSTON, Sebastian L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Respiratory Viruses, Symptoms, and Inflammatory Markers in Acute Exacerbations and Stable Chronic Obstructive Pulmonary Disease by SEEMUNGAL, TERENCE, HARPER-OWEN, RHIAN, BHOWMIK, ANGSHU, MORIC, IVANA, SANDERSON, GWENDOLYN, MESSAGE, SIMON, MACCALLUM, PETER, MEADE, THOMAS W, JEFFRIES, DONALD J, JOHNSTON, SEBASTIAN L, WEDZICHA, JADWIGA A

“…The effects of respiratory viral infection on the time course of chronic obstructive pulmonary disease (COPD) exacerbation were examined by monitoring changes…”
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Lymphocyte subsets in experimental rhinovirus infection in chronic obstructive pulmonary disease by Mallia, Patrick, Message, Simon D, Contoli, Marco, Gray, Katrina, Telcian, Aurica, Laza-Stanca, Vasile, Papi, Alberto, Stanciu, Luminita A, Elkin, Sarah, Kon, Onn M, Johnson, Malcolm, Johnston, Sebastian L

“…Summary Background COPD is associated with increased numbers of T cells in the lungs, particularly CD8+ T cells. The mechanisms of increased T cells are…”
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