Search Results - "Messa, Massimo"

The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt by Cimini, Sara, Sclip, Alessandra, Mancini, Simona, Colombo, Laura, Messa, Massimo, Cagnotto, Alfredo, Di Fede, Giuseppe, Tagliavini, Fabrizio, Salmona, Mario, Borsello, Tiziana

“…Alzheimer disease (AD) is the most prevalent form of dementia. Loss of hippocampal synapses is the first neurodegenerative event in AD. Synaptic loss has been…”
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The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins by Manzoni, Claudia, Colombo, Laura, Bigini, Paolo, Diana, Valentina, Cagnotto, Alfredo, Messa, Massimo, Lupi, Monica, Bonetto, Valentina, Pignataro, Mauro, Airoldi, Cristina, Sironi, Erika, Williams, Alun, Salmona, Mario

“…Accumulation of β-sheet-rich peptide (Aβ) is strongly associated with Alzheimer's disease, characterized by reduction in synapse density, structural…”
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The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling by Bottazzi, Barbara, Inforzato, Antonio, Messa, Massimo, Barbagallo, Marialuisa, Magrini, Elena, Garlanda, Cecilia, Mantovani, Alberto

“…Summary Pentraxins are a superfamily of fluid phase pattern recognition molecules conserved in evolution and characterized by a cyclic multimeric structure…”
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Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer’s disease by Balducci, Claudia, Frasca, Angelisa, Zotti, Margherita, La Vitola, Pietro, Mhillaj, Emanuela, Grigoli, Emanuele, Iacobellis, Martina, Grandi, Federica, Messa, Massimo, Colombo, Laura, Molteni, Monica, Trabace, Luigia, Rossetti, Carlo, Salmona, Mario, Forloni, Gianluigi

“…Highlights • An ICV injection of AβO impairing memory leads also to a rapid glial activation. • Anti-inflammatory drugs prevent the AβO-mediated memory…”
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An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicity in Vivo by Fluharty, Brian R., Biasini, Emiliano, Stravalaci, Matteo, Sclip, Alessandra, Diomede, Luisa, Balducci, Claudia, La Vitola, Pietro, Messa, Massimo, Colombo, Laura, Forloni, Gianluigi, Borsello, Tiziana, Gobbi, Marco, Harris, David A.

“…A hallmark of Alzheimer disease (AD) is the accumulation of the amyloid-β (Aβ) peptide in the brain. Considerable evidence suggests that soluble Aβ oligomers…”
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Sleep inhibition induced by amyloid‐β oligomers is mediated by the cellular prion protein by Del Gallo, Federico, Bianchi, Susanna, Bertani, Ilaria, Messa, Massimo, Colombo, Laura, Balducci, Claudia, Salmona, Mario, Imeri, Luca, Chiesa, Roberto

“…Sleep is severely impaired in patients with Alzheimer's disease. Amyloid‐β deposition in the brain of Alzheimer's disease patients is a key event in its…”
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Natural Compounds against Neurodegenerative Diseases: Molecular Characterization of the Interaction of Catechins from Green Tea with A beta 1-42, PrP106-126, and Ataxin-3 Oligomers by Sironi, Erika, Colombo, Laura, Lompo, Angela, Messa, Massimo, Bonanomi, Marcella, Regonesi, Maria Elena, Salmona, Mario, Airoldi, Cristina

“…By combining NMR spectroscopy, transmission electron microscopy, and circular dichroism we have identified the structural determinants involved in the…”
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The Peculiar Role of the A2V Mutation in Amyloid-β (Aβ) 1–42 Molecular Assembly by Messa, Massimo, Colombo, Laura, del Favero, Elena, Cantù, Laura, Stoilova, Tatiana, Cagnotto, Alfredo, Rossi, Alessandro, Morbin, Michela, Di Fede, Giuseppe, Tagliavini, Fabrizio, Salmona, Mario

“…We recently reported a novel Aβ precursor protein mutation (A673V), corresponding to position 2 of Aβ1–42 peptides (Aβ1–42A2V), that caused an early onset…”
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Amyloidβ Peptides in interaction with raft-mime model membranes: a neutron reflectivity insight by Rondelli, Valeria, Brocca, Paola, Motta, Simona, Messa, Massimo, Colombo, Laura, Salmona, Mario, Fragneto, Giovanna, Cantù, Laura, Del Favero, Elena

“…The role of first-stage β–amyloid aggregation in the development of the Alzheimer disease, is widely accepted but still unclear. Intimate interaction with the…”
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Natural Compounds against Neurodegenerative Diseases: Molecular Characterization of the Interaction of Catechins from Green Tea with Aβ1-42, PrP106-126, and Ataxin-3 Oligomers by Sironi, Erika, Colombo, Laura, Lompo, Angela, Messa, Massimo, Bonanomi, Marcella, Regonesi, Maria Elena, Salmona, Mario, Airoldi, Cristina

“…By combining NMR spectroscopy, transmission electron microscopy, and circular dichroism we have identified the structural determinants involved in the…”
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Curcumin derivatives as new ligands of Aβ peptides by Airoldi, Cristina, Zona, Cristiano, Sironi, Erika, Colombo, Laura, Messa, Massimo, Aurilia, Dario, Gregori, Maria, Masserini, Massimo, Salmona, Mario, Nicotra, Francesco, La Ferla, Barbara

“…Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been…”
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β-Amyloid 1-42 induces physiological transcriptional regulation of BACE1 by Piccini, Alessandra, Borghi, Roberta, Guglielmotto, Michela, Tamagno, Elena, Cirmena, Gabriella, Garuti, Anna, Pollero, Valeria, Cammarata, Sergio, Fornaro, Michele, Messa, Massimo, Colombo, Laura, Salmona, Mario, Perry, George, Tabaton, Massimo

“…J. Neurochem. (2012) 122, 1023–1031. The pathogenesis of Alzheimer’s disease (AD) is only partially understood. β‐amyloid (Aβ) is physiologically generated by…”
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Good gene, bad gene: new APP variant may be both by Di Fede, Giuseppe, Catania, Marcella, Morbin, Michela, Giaccone, Giorgio, Moro, Maria Luisa, Ghidoni, Roberta, Colombo, Laura, Messa, Massimo, Cagnotto, Alfredo, Romeo, Margherita, Stravalaci, Matteo, Diomede, Luisa, Gobbi, Marco, Salmona, Mario, Tagliavini, Fabrizio

“…APP mutations cause Alzheimer disease (AD) with virtually complete penetrance. We found a novel APP mutation (A673V) in the homozygous state in a patient with…”
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Natural Compounds against Neurodegenerative Diseases: Molecular Characterization of the Interaction of Catechins from Green Tea with A[beta]1-42, PrP106-126, and Ataxin-3 Oligomers by Sironi, Erika, Colombo, Laura, Lompo, Angela, Messa, Massimo, Bonanomi, Marcella, Regonesi, Maria Elena, Salmona, Mario, Airoldi, Cristina

“…By combining NMR spectroscopy, transmission electron microscopy, and circular dichroism we have identified the structural determinants involved in the…”
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The cell-permeable Aβ1-6A2V TAT(D) peptide reverts synaptopathy induced by Aβ1-42wt by Cimini, Sara, Sclip, Alessandra, Mancini, Simona, Colombo, Laura, Messa, Massimo, Cagnotto, Alfredo, Di Fede, Giuseppe, Tagliavini, Fabrizio, Salmona, Mario, Borsello, Tiziana

“…Abstract Alzheimer disease (AD) is the most prevalent form of dementia. Loss of hippocampal synapses is the first neurodegenerative event in AD. Synaptic loss…”
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Soluble Aβ oligomer-induced synaptopathy: c-Jun N-terminal kinase's role by Sclip, Alessandra, Arnaboldi, Andrea, Colombo, Isabella, Veglianese, Pietro, Colombo, Laura, Messa, Massimo, Mancini, Simona, Cimini, Sara, Morelli, Federica, Antoniou, Xanthi, Welker, Egbert, Salmona, Mario, Borsello, Tiziana

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[beta]-Amyloid 1-42 induces physiological transcriptional regulation of BACE1 by Piccini, Alessandra, Borghi, Roberta, Guglielmotto, Michela, Tamagno, Elena, Cirmena, Gabriella, Garuti, Anna, Pollero, Valeria, Cammarata, Sergio, naro, Michele, Messa, Massimo, Colombo, Laura, Salmona, Mario, Perry, George, Tabaton, Massimo

“…J. Neurochem. (2012) 122, 1023-1031. The pathogenesis of Alzheimer's disease (AD) is only partially understood. [beta]-amyloid (A[beta]) is physiologically…”
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Overcoming synthetic Aβ peptide aging: a new approach to an age-old problem by Manzoni, Claudia, Colombo, Laura, Messa, Massimo, Cagnotto, Alfredo, Cantù, Laura, Del Favero, Elena, Salmona, Mario

“…Investigations of amyloidogenic diseases use synthetic peptides for cell-free and in vitro studies. However, amyloidogenic peptides often show intrinsic…”
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The Molecular Assembly of Amyloid A[beta] Controls Its Neurotoxicity and Binding to Cellular Proteins by Manzoni, Claudia, Colombo, Laura, Bigini, Paolo, Diana, Valentina, Cagnotto, Alfredo, Messa, Massimo, Lupi, Monica, Bonetto, Valentina, Pignataro, Mauro, Airoldi, Cristina, Sironi, Erika, Williams, Alun, Salmona, Mario

“…Accumulation of [beta]-sheet-rich peptide (A[beta]) is strongly associated with Alzheimer's disease, characterized by reduction in synapse density, structural…”
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Synthetic Abeta 1-40 oligomers impair recognition memory in mice by Balducci, Claudia, Messa, Massimo, Colombo, Laura, Salmona, Mario, Forloni, Gianluigi

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