Search Results - "Messa, Caterina"
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Inflammatory Mechanisms of HCC Development
Published in Cancers (10-03-2020)“…HCC (hepatocellular carcinoma) is the second leading cause of cancer deaths worldwide, with several etiologic causes, mostly inflammation-associated. Different…”
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Molecular mechanisms of synergistic action of Ramucirumab and Paclitaxel in Gastric Cancers cell lines
Published in Scientific reports (28-04-2020)“…Ramucirumab is approved both as monotherapy and in combination with Paclitaxel for advanced gastric cancer in patients with disease progression after…”
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3
Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are Mediated by CB1 Receptor in Human Colon Cancer Cell Lines
Published in Journal of cellular physiology (01-12-2015)“…Quercetin, the major constituent of flavonoid and widely present in fruits and vegetables, is an attractive compound for cancer prevention due to its…”
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Platelet extracts induce growth, migration and invasion in human hepatocellular carcinoma in vitro
Published in BMC cancer (27-01-2014)“…Thrombocytopenia has been reported to be associated with small size HCCs, and thrombocytosis to be associated with large size HCCs. The aim was to examine the…”
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5
IGF-1R tyrosine kinase inhibitors and Vitamin K1 enhance the antitumor effects of Regorafenib in HCC cell lines
Published in Oncotarget (28-11-2017)“…The recent RESORCE trial showed that treatment with Regorafenib after Sorafenib failure provided a significant improvement in overall survival in HCC patients…”
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6
Nonalcoholic Fatty Liver Disease: Focus on New Biomarkers and Lifestyle Interventions
Published in International journal of molecular sciences (09-04-2021)“…Nonalcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome, characterized from pathological changes in lipid and…”
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Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: Growth inhibition, quiescence, and recovery
Published in Journal of cellular physiology (01-02-2013)“…To evaluate the growth‐inhibitory properties of the potent multi‐kinase antagonist Regorafenib (Fluoro‐Sorafenib), which was synthesized as a more potent…”
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Corrigendum: Variations in circulating levels of angiopoietin-2 over time are predictive of ramucirumab-paclitaxel therapy outcome in advanced gastric cancer: results of prospective study
Published in Frontiers in oncology (14-04-2023)“…[This corrects the article DOI: 10.3389/fonc.2022.862116.]…”
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Variations in Circulating Levels of Angiopoietin-2 Over Time Are Predictive of Ramucirumab-Paclitaxel Therapy Outcome in Advanced Gastric Cancer: Results of Prospective Study
Published in Frontiers in oncology (06-04-2022)“…The combination of paclitaxel and ramucirumab is the second-line therapy of choice in the treatment of advanced gastric cancer. To date, no biomarkers are…”
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The multiple combination of Paclitaxel, Ramucirumab and Elacridar reverses the paclitaxel-mediated resistance in gastric cancer cell lines
Published in Frontiers in oncology (16-02-2023)“…Paclitaxel (PTX) interferes with microtubule architecture by binding to β-tubulin, thereby blocking progression at the G2/M phase and inducing apoptosis. This…”
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11
FZD10 Carried by Exosomes Sustains Cancer Cell Proliferation
Published in Cells (Basel, Switzerland) (25-07-2019)“…Extracellular vesicles (EVs) are involved in intercellular communication during carcinogenesis, and cancer cells are able to secrete EVs, in particular…”
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12
Antagonism of sorafenib and regorafenib actions by platelet factors in hepatocellular carcinoma cell lines
Published in BMC cancer (21-05-2014)“…Platelets are frequently altered in hepatocellular carcinoma (HCC) patients. Platelet lysates (hPL) can enhance HCC cell growth and decrease apoptosis. The…”
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13
Modulation of Regorafenib effects on HCC cell lines by epidermal growth factor
Published in Cancer chemotherapy and pharmacology (01-06-2015)“…Purpose Blood platelet numbers are correlated to growth and aggressiveness of several tumor types, including hepatocellular carcinoma (HCC). We previously…”
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14
VEGFA Status as a Predictive Marker of Therapy Outcome in Metastatic Gastric Cancer Patients Following Ramucirumab-Based Treatment
Published in Biomedicines (07-10-2023)“…Metastatic gastric cancer (mGC) often has a poor prognosis and may benefit from a few targeted therapies. Ramucirumab-based anti-angiogenic therapy targeting…”
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15
Polyunsaturated fatty acids reduce fatty acid synthase and hydroxy-methyl-glutaryl CoA-reductase gene expression and promote apoptosis in HepG2 cell line
Published in Lipids in health and disease (18-01-2011)“…n-3 and n-6 polyunsaturated fatty acids (PUFAs) are the two major classes of PUFAs encountered in the diet, and both classes of fatty acids are required for…”
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Synergic effect of eicosapentaenoic acid and lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells
Published in Lipids in health and disease (30-11-2010)“…PUFAs are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme catalyzing the conversion of HMGCoA to mevalonate, the rate…”
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17
Modulation of Doxorubicin mediated growth inhibition of hepatocellular carcinoma cells by platelet lysates
Published in Anti-cancer agents in medicinal chemistry (01-01-2014)“…Platelet extracts can stimulate cell growth and contribute to tumor biology. It was recently shown that they stimulate the growth of hepatocellular carcinoma…”
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Up-regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Left-sided Human Colon Cancer
Published in Anticancer research (01-11-2004)“…Background. We evaluated the HMGCoA reductase activity and LDL receptor levels in human colon cancer as well as the effects of simvastatin on in vitro cell…”
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N6‐isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1
Published in International journal of cancer (15-03-2009)“…N6‐isopentenyladenosine (i6A) is a modified nucleoside with a pentaatomic isopentenyl derived from mevalonate that induces inhibition of tumor cell…”
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20
Effect of genistein on cholesterol metabolism-related genes in a colon cancer cell line
Published in Genes & nutrition (01-04-2008)“…The major soy-derived isoflavones such as genistein has been demonstrated to possess anticarcinogenic activity in animal model systems. The present study was…”
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