A Comparative Evaluation of the Photosensitizing Efficiency of Porphyrins, Chlorins and Isobacteriochlorins toward Melanoma Cancer Cells

Skin cancer is one of the cancers that registers the highest number of new cases annually. Among all forms of skin cancer, melanoma is the most invasive and deadliest. The resistance of this form of cancer to conventional treatments has led to the employment of alternative/complementary therapeutic...

Full description

Saved in:

Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 28; no. 12; p. 4716
Main Authors:	Castro, Kelly A D F, Moura, Nuno M M, Simões, Mário M Q, Mesquita, Mariana M Q, Ramos, Loyanne C B, Biazzotto, Juliana C, Cavaleiro, José A S, Faustino, M Amparo F, Neves, Maria Graça P M S, da Silva, Roberto S
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-06-2023 MDPI
Subjects:	Animals Cancer Cancer cells Cancer therapies Care and treatment Cell death Cell Line, Tumor chlorin Comparative analysis Dermatitis, Phototoxic - drug therapy Efficiency Health aspects Humans isobacteriochlorin Melanoma Melanoma - drug therapy Melanoma - pathology Mice Photochemotherapy Photochemotherapy - methods Photodynamic therapy Photosensitization photosensitizer Photosensitizing Agents - therapeutic use porphyrin Porphyrins Porphyrins - pharmacology Porphyrins - therapeutic use Radiation therapy Skin cancer Skin Neoplasms - drug therapy Tumor cells Tumors skin cancer porphyrin photodynamic therapy isobacteriochlorin chlorin melanoma photosensitizer
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Skin cancer is one of the cancers that registers the highest number of new cases annually. Among all forms of skin cancer, melanoma is the most invasive and deadliest. The resistance of this form of cancer to conventional treatments has led to the employment of alternative/complementary therapeutic approaches. Photodynamic therapy (PDT) appears to be a promising alternative to overcome the resistance of melanoma to conventional therapies. PDT is a non-invasive therapeutic procedure in which highly reactive oxygen species (ROS) are generated upon excitation of a photosensitizer (PS) when subjected to visible light of an adequate wavelength, resulting in the death of cancer cells. In this work, inspired by the efficacy of tetrapyrrolic macrocycles to act as PS against tumor cells, we report the photophysical characterization and biological assays of isobacteriochlorins and their corresponding chlorins and porphyrins against melanoma cancer cells through a photodynamic process. The non-tumoral L929 fibroblast murine cell line was used as the control. The results show that the choice of adequate tetrapyrrolic macrocycle-based PS can be modulated to improve the performance of PDT.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules28124716