Search Results - "Mesleh, Michael F."

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9 by Maji, Basudeb, Gangopadhyay, Soumyashree A., Lee, Miseon, Shi, Mengchao, Wu, Peng, Heler, Robert, Mok, Beverly, Lim, Donghyun, Siriwardena, Sachini U., Paul, Bishwajit, Dančík, Vlado, Vetere, Amedeo, Mesleh, Michael F., Marraffini, Luciano A., Liu, David R., Clemons, Paul A., Wagner, Bridget K., Choudhary, Amit

“…The precise control of CRISPR-Cas9 activity is required for a number of genome engineering technologies. Here, we report a generalizable platform that provided…”
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Three-dimensional Structure of the Channel-forming Trans-membrane Domain of Virus Protein “u” (Vpu) from HIV-1 by Park, Sang Ho, Mrse, Anthony A., Nevzorov, Alexander A., Mesleh, Michael F., Oblatt-Montal, Myrta, Montal, Mauricio, Opella, Stanley J.

“…The three-dimensional structure of the channel-forming trans-membrane domain of virus protein “u” (Vpu) of HIV-1 was determined by NMR spectroscopy in micelle…”
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Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides by Reidenbach, Andrew G, Minikel, Eric Vallabh, Zhao, Hien T, Guzman, Stacy G, Leed, Alison J, Mesleh, Michael F, Kordasiewicz, Holly B, Schreiber, Stuart L, Vallabh, Sonia M

“…Antisense oligonucleotides (ASOs) designed to lower prion protein (PrP) expression in the brain through RNase H1-mediated degradation of PrP RNA are in…”
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An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin by Yoganathan, Sabesan, Yin, Ning, He, Yong, Mesleh, Michael F, Gu, Yu Gui, Miller, Scott J

“…Herein we report a direct and efficient method for the synthesis of four new carboxylate-isostere analogs of daptomycin. The side chain carboxylic acid…”
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Structure of the Coat Protein in fd Filamentous Bacteriophage Particles Determined by Solid-State NMR Spectroscopy by Zeri, Ana Carolina, Mesleh, Michael F., Nevzorov, Alexander A., Opella, Stanley J.

“…The atomic resolution structure of fd coat protein determined by solid-state NMR spectroscopy of magnetically aligned filamentous bacteriophage particles…”
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Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction by McKinney, David C, McMillan, Brian J, Ranaghan, Matthew J, Moroco, Jamie A, Brousseau, Merissa, Mullin-Bernstein, Zachary, O’Keefe, Meghan, McCarren, Patrick, Mesleh, Michael F, Mulvaney, Kathleen M, Robinson, Foxy, Singh, Ritu, Bajrami, Besnik, Wagner, Florence F, Hilgraf, Robert, Drysdale, Martin J, Campbell, Arthur J, Skepner, Adam, Timm, David E, Porter, Dale, Kaushik, Virendar K, Sellers, William R, Ianari, Alessandra

“…PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5…”
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NMR Structural Characterization of a Minimal Peptide Antagonist Bound to the Extracellular Domain of the Corticotropin-releasing Factor1 Receptor by Mesleh, Michael F., Shirley, William A., Heise, Christopher E., Ling, Nicholas, Maki, Richard A., Laura, Richard P.

“…Natural peptide agonists of corticotrophin-releasing factor (CRF) receptors bind to the receptor by a two-site mechanism as follows: the carboxyl end of the…”
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A drug discovery toolbox for Nuclear Magnetic Resonance (NMR) characterization of ligands and their targets by LeBlanc, Regan M., Mesleh, Michael F.

“…Information about the structure, dynamics, and ligand-binding properties of biomolecules can be derived from Nuclear Magnetic Resonance (NMR) spectroscopy and…”
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A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules by Lim, Donghyun, Zhou, Qingxuan, Cox, Kurt J., Law, Benjamin K., Lee, Miseon, Kokkonda, Praveen, Sreekanth, Vedagopuram, Pergu, Rajaiah, Chaudhary, Santosh K., Gangopadhyay, Soumyashree A., Maji, Basudeb, Lai, Sophia, Amako, Yuka, Thompson, David B., Subramanian, Hari K. K., Mesleh, Michael F., Dančík, Vlado, Clemons, Paul A., Wagner, Bridget K., Woo, Christina M., Church, George M., Choudhary, Amit

“…The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in a demand for inhibitory anti-CRISPR molecules. The small-molecule…”
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Multimodal small-molecule screening for human prion protein binders by Reidenbach, Andrew G., Mesleh, Michael F., Casalena, Dominick, Vallabh, Sonia M., Dahlin, Jayme L., Leed, Alison J., Chan, Alix I., Usanov, Dmitry L., Yehl, Jenna B., Lemke, Christopher T., Campbell, Arthur J., Shah, Rishi N., Shrestha, Om K., Sacher, Joshua R., Rangel, Victor L., Moroco, Jamie A., Sathappa, Murugappan, Nonato, Maria Cristina, Nguyen, Kong T., Wright, S. Kirk, Liu, David R., Wagner, Florence F., Kaushik, Virendar K., Auld, Douglas S., Schreiber, Stuart L., Minikel, Eric Vallabh

“…Prion disease is a rapidly progressive neurodegenerative disorder caused by misfolding and aggregation of the prion protein (PrP), and there are currently no…”
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The Autophagy-Related Beclin‑1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity by Ranaghan, Matthew J, Durney, Michael A, Mesleh, Michael F, McCarren, Patrick R, Garvie, Colin W, Daniels, Douglas S, Carey, Kimberly L, Skepner, Adam P, Levine, Beth, Perez, Jose R

“…Beclin-1 (BECN1) is an essential component of macroautophagy. This process is a highly conserved survival mechanism that recycles damaged cellular components…”
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Structure–Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of Clostridium difficile-Associated Diarrhea by Yin, Ning, Li, Jing, He, Yong, Herradura, Prudencio, Pearson, Andre, Mesleh, Michael F, Mascio, Carmela T, Howland, Karen, Steenbergen, Judith, Thorne, Grace M, Citron, Diane, Van Praagh, Andrew D. G, Mortin, Lawrence I, Keith, Dennis, Silverman, Jared, Metcalf, Chester

“…Novel cyclic lipopeptides with different acyl tails were synthesized via a semisynthetic approach. Structure–activity relationship studies revealed that…”
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Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB by Mesleh, Michael F., Cross, Jason B., Zhang, Jing, Kahmann, Jan, Andersen, Ole A., Barker, John, Cheng, Robert K., Felicetti, Brunella, Wood, Michael, Hadfield, Andrea T., Scheich, Christoph, Moy, Terence I., Yang, Qingyi, Shotwell, Joseph, Nguyen, Kien, Lippa, Blaise, Dolle, Roland, Ryan, M. Dominic

“…[Display omitted] Inhibitors of the ATPase function of bacterial DNA gyrase, located in the GyrB subunit and its related ParE subunit in topoisomerase IV, have…”
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Targeting Bacterial Cell Wall Peptidoglycan Synthesis by Inhibition of Glycosyltransferase Activity by Mesleh, Michael F., Rajaratnam, Premraj, Conrad, Mary, Chandrasekaran, Vasu, Liu, Christopher M., Pandya, Bhaumik A., Hwang, You Seok, Rye, Peter T., Muldoon, Craig, Becker, Bernd, Zuegg, Johannes, Meutermans, Wim, Moy, Terence I.

“…Synthesis of bacterial cell wall peptidoglycan requires glycosyltransferase enzymes that transfer the disaccharide–peptide from lipid II onto the growing…”
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Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design by Cross, Jason B, Zhang, Jing, Yang, Qingyi, Mesleh, Michael F, Romero, Jan Antoinette C, Wang, Bin, Bevan, Doug, Poutsiaka, Katherine M, Epie, Felix, Moy, Terence, Daniel, Anu, Shotwell, Joseph, Chamberlain, Brian, Carter, Nicole, Andersen, Ole, Barker, John, Ryan, M. Dominic, Metcalf, Chester A, Silverman, Jared, Nguyen, Kien, Lippa, Blaise, Dolle, Roland E

“…The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA…”
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NMR Structure Determination of a Membrane Protein with Two Transmembrane Helices in Micelles:  MerF of the Bacterial Mercury Detoxification System by Howell, Stanley C, Mesleh, Michael F, Opella, Stanley J

“…The three-dimensional backbone structure of a membrane protein with two transmembrane helices in micelles was determined using solution NMR methods that rely…”
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Marmoset Fine B Cell and T Cell Epitope Specificities Mapped onto a Homology Model of the Extracellular Domain of Human Myelin Oligodendrocyte Glycoprotein by Mesleh, Michael F., Belmar, Nicole, Lu, Chuan Wei, Krishnan, V.V., Maxwell, Robert S., Genain, Claude P., Cosman, Monique

“…Aberrant association of autoantibodies with myelin oligodendrocyte glycoprotein (MOG), an integral membrane protein of the central nervous system (CNS) myelin,…”
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Dipolar Waves as NMR maps of helices in proteins by Mesleh, Michael F, Opella, Stanley J

“…Dipolar Waves describe the periodic variation in the magnitudes of dipolar couplings in the backbone of a protein as a function of residue number. They provide…”
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Dipolar Waves Map the Structure and Topology of Helices in Membrane Proteins by Mesleh, Michael F, Lee, Sangwon, Veglia, Gianluigi, Thiriot, David S, Marassi, Francesca M, Opella, Stanley J

“…Dipolar waves describe the structure and topology of helices in membrane proteins. The fit of sinusoids with the 3.6 residues per turn period of ideal…”
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Dipolar Waves as NMR Maps of Protein Structure by Mesleh, Michael F, Veglia, Gianluigi, DeSilva, Tara M, Marassi, Francesca M, Opella, Stanley J

“…The anisotropy of nuclear spin interactions results in a unique mapping of structure to the resonance frequencies and split tings observed in NMR spectra,…”
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